Skip to main content

Table 1 Correlation of demographic, clinico-pathological parameters of breast cancer patients with mean percentage of CD3+, CD8+ and CD45RO+ T lymphocytes

From: CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

  

CD8+

 

CD3+

 

CD45RO+

 

Parameters

No (%)

Mean (SD)

p

Mean (SD)

p

Mean (SD)

p

Age

  

0.27

 

0.30

 

0.37

 < 50

18 (47.4 %)

15.1 (10.2)

 

39.1 (23.6)

 

34.6 (30.9)

 

 50+

20 (52.6 %)

19.7 (12.2)

 

48.0 (26.7)

 

42.6 (22.6)

 

Gender

 Female

43 (100.0 %)

16.7 (11.3)

 

43.2 (25.3)

 

38.2 (26.1)

 

Diagnosis

  

0.09

 

0.35

 

0.24

 IDC

38 (88.4 %)

18.1 (11.1)

 

44.1 (25.3)

 

36.5 (26.8)

 

 ILC

3 (7.0 %)

4.5 (2.3)

 

50.0 (26.2)

 

62.7 (3.1)

 

 Others

2 (4.7 %)

10.5 (13.4)

 

18.5 (19.1)

 

33.0 (7.1)

 

Grade

  

0.48

 

0.14

 

0.44

 1

5 (11.6 %)

11.0 (6.9)

 

33.2 (25.2)

 

38.4 (19.0)

 

 2

23 (53.5 %)

18.0 (9.9)

 

50.4 (26.2)

 

42.5 (25.2)

 

 3

15 (34.9 %)

16.9 (14.0)

 

34.9 (21.3)

 

31.0 (29.6)

 

LVI

  

0.39

 

0.12

 

0.21

 Positive

18 (41.9 %)

14.9 (11.5)

 

36.1 (25.8)

 

32.3 (28.6)

 

 Negative

25 (58.1 %)

18.0 (11.2)

 

48.5 (24.0)

 

42.6 (23.8)

 

Lymph node

  

0.29

 

0.04

 

0.32

 Positive

19 (63.3 %)

17.7 (10.1)

 

47.9 (28.2)

 

41.5 (28.1)

 

 Negative

11 (36.7 %)

13.3 (11.1)

 

30.6 (13.8)

 

30.7 (27.1)

 

Estrogen receptor

  

0.086

 

0.87

 

0.74

 Positive

25 (58.1 %)

13.8 (7.3)

 

42.7 (26.4)

 

37.0 (22.4)

 

 Negative

18 (41.9 %)

20.7 (14.5)

 

44.0 (24.4)

 

39.9 (31.4)

 

Progesterone receptor

  

0.086

 

0.87

 

0.74

 Positive

25 (58.1 %)

13.8 (7.3)

 

42.7 (26.4)

 

37.0 (22.4)

 

 Negative

18 (41.9 %)

20.7 (14.5)

 

44.0 (24.4)

 

39.9 (31.4)

 

HER2/neu

  

0.006

 

0.83

 

0.56

 Positive

11 (25.6 %)

24.5 (13.5)

 

44.7 (25.0)

 

33.9 (26.3)

 

 Negative

32 (74.4 %)

13.8 (9.0)

 

42.7 (25.8)

 

39.5 (26.3)

 

Molecular subtype

  

0.034

 

0.48

 

0.82

 Luminal Aa

23 (53.5 %)

13.5 (7.4)

 

44.7 (26.7)

 

37.3 (23.3)

 

 Luminal Bb

2 (4.7 %)

17.0 (8.5)

 

21.5 (9.2)

 

34.0 (5.7)

 

 TNBCc

9 (20.9 %)

14.5 (13.0)

 

38.2 (24.3)

 

45.3 (33.6)

 

 HER2/neu Positived

9 (20.9 %)

26.1 (14.2)

 

50.5 (24.5)

 

33.9 (29.8)

 
  1. IDC Invasive ductal carcinoma, ILC Invasive lobular carcinoma, SD standard deviation, LVI Lymphovascular invasion
  2. aLuminal A = ER (+ve) and/or PR (+ve) and HER2/neu (−ve); bLuminal B = ER (+ve) and/or PR (+ve) and HER2/neu (+ve); cTNBC: Triple negative = ER (−ve) and/or PR (−ve) and HER2/neu (−ve); dHER2/neu positive = ER (−ve) and/or PR (−ve) and HER2/neu (+ve)