Table 4 Median change in absolute neutrophil count from pre-dose to last dose and from last dose to 24 h after the last dose in healthy volunteer subjects in the MAD cohorts
Cohort | n | PMN (109/ml) pre-dose to 9th dose median change (± SD) | P-value | PMN (109/ml) 9th dose to 24 h post median change (± SD) | P-value |
|---|---|---|---|---|---|
placebo | 6 | -0.35 (± 0.99) | NS | 0.25 (± 0.30) | 0.05 |
2 mg/kg | 6 | 0.40 (± 0.45) | NS | -0.15 (± 0.47) | NS |
10 mg/kg | 6 | 0.45 (± 0.84) | 0.05 | -0.10 (± 0.48) | NS |
40 mg/kg | 6 | 0.85 (± 0.74) | 0.04 | -0.40 (± 0.73) | NS |