Total number of studies | 160 | |
---|---|---|
Total number of mice | 13,811 | |
Internal validity | ||
Randomization | 60 (37) | |
Sample size justification | 13 (8) | |
Blinded assessment of treatment effect | 9 (6) | |
Experimental flow | 8 (5) | |
Dose response | 22 (14) | |
Construct validity | ||
Baseline characterization | 5 (3) | |
Disease match | 80 (50) | |
Age match | 11 (7) | |
Mechanistic response to treatment | 144 (90) | |
External validity | ||
Model replication | 86 (54) | |
Research purpose | ||
Translational claim | 133 (83) |