Table 1 Expression levels of immune response genes in SPT-2101 treated rats. Genes were selected from those included in the RT² Profiler™ PCR Array Rat Innate & Adaptive Immune Responses and represented in Fig. 6A. RT-qPCR expression levels of selected genes in LPS and LPS plus SPT-2101 experimental groups (n ≥ 3 rats per experimental condition), 72 h after the first LPS injection. Results were calculated as 2^–ΔΔCt (RQ, expressed as mean ± SEM), using Tbp as the reference gene, and normalized to control rats without LPS. Column on the right shows fold-change between LPS-challenged rats treated or not with SPT-2101. In bold, fold changes > 1 and <-0.5

1.434 ± 0.313

0.709 ± 0.191

-0.506

1.788 ± 0.142

1.731 ± 0.418

-0.032

3.645 ± 0.161

0.960 ± 0.207

-0.736

1.667 ± 0.079

1.074 ± 0.069

-0.355

2.544 ± 0.153

3.451 ± 0.741

0.357

1.728 ± 0.206

1.786 ± 0.375

0.034

1.856 ± 0.376

2.712 ± 1.012

0.462

3.121 ± 0.204

5.886 ± 1.000

0.886

34.920 ± 9.145

0.590 ± 0.389

-0.983

20.243 ± 11.997

9.785 ± 7.904

-0.517

5.179 ± 0.094

2.590 ± 1.088

-0.500

8.328 ± 0.921

2.758 ± 0.533

-0.668

55.325 ± 47.534

9.258 ± 4.617

-0.833

2.530 ± 0.140

5.094 ± 0.208

1.013

3.551 ± 0.173

1.138 ± 0.254

-0.679

3.781 ± 2.305

6.519 ± 3.698

0.724

1.609 ± 0.274

0.905 ± 0.111

-0.437

29.825 ± 17.028

52.233 ± 33.181

0.751

2.218 ± 0.065

1.293 ± 0.674

-0.417

10.199 ± 2.051

9.808 ± 1.543

-0.038

1.492 ± 0.095

0.249 ± 0.019

-0.833

1.380 ± 0.138

1.611 ± 0.437

0.167

2.499 ± 0.429

2.929 ± 0.678

0.172

0.129 ± 0.048

0.005 ± 0.002

-0.960