Fig. 3
A A boxplot is presented to compare the age at end-stage renal disease (ESRD) among patients with different types of variants in PKD1, specifically PKD1-truncating (PKD1-T) and PKD1-missense (PKD1-M), as well as variants in PKD2. The boxplot provides a visual representation of the distribution and median age at ESRD for each variant type, allowing for a comparison of disease progression among the different genetic variants. B Kaplan–Meier survival curves are displayed, depicting the probability of survival without reaching ESRD over time, based on the gene involved (PKD1 or PKD2) and the type of mutation. The curves are censored, meaning that the age and condition (with or without ESRD) at the time of recruitment are taken into account. This analysis provides insights into the differential risk of ESRD development based on the specific gene and mutation type, enabling the assessment of disease prognosis. C A boxplot is presented to compare the age at ESRD among patients stratified into high, intermediate, or low-risk categories based on the ProPKD score assessment. The ProPKD score is a risk prediction tool for CKD progression in ADPKD. The boxplot allows for a visual comparison of the age at ESRD among patients with different risk scores, providing information on the relationship between risk category and disease progression. D Kaplan–Meier survival curves are displayed, similar to section B, but now based on the risk stratification according to the ProPKD score. The curves depict the probability of survival without reaching ESRD over time, considering the risk categories. The analysis allows for an evaluation of the impact of risk stratification on disease prognosis and the likelihood of ESRD development