Fig. 1

Plasma galectin-9 correlates strongly with MTO during SIV infection. a Spearman r and Bonferroni corrected p-values of MTO correlation with 865 different markers were measured from longitudinal samples collected from 22 SIV-infected animals. The horizontal dashed line indicates the adjusted p value of 0.05. The calculation only included time points of the post-acute phase (≥ 50 days post-infection) from animals ultimately requiring medical cull. b Correlation matrix for MTO and the five BrdU-independent markers identified in panel a. Circle size and colour represent correlation strength and direction, respectively. Circles were drawn only for p value < 0.05. Contrary to panel a, the calculation included all available time points from all animals. c-g Measured MTO rates in relation to the five identified markers. Lines connect time points for each animal in chronological order. All available time points are represented. Spearman r and p values are the same as calculated for panel b for all animals and time points. Plain black circles are the time points used for panel a