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Fig. 1 | Translational Medicine Communications

Fig. 1

From: iMN041 is an immunotherapeutic and an effective treatment in mouse xenograft models of pancreatic cancer, renal cancer and triple negative breast cancer

Fig. 1

Analysis of live cells in mouse Renca tumors. Comparisons of tumors treated with two doses of 1 mg iMN041 SC qod followed by a 48 h observation period or vehicle control (n = 4/group), where * signifies differences where p < 0.05 and ** p < 0.01. A Gating strategy for granzyme B in NK cells. B Gating strategy for granzyme B in NKT cells. C The percentage of CD45+ cells positive for granzyme B. D Mean fluorescence intensity (MFI) of CD45+ cells for granzyme B. E Gating strategy for CD4-T and CD8-T cells. F Comparison of CD8-T to Treg percentage cells ratio and CD4-T to Treg percentage cells ratio. G, I Comparison of live CD45+ cells and live tumor cells, respectively. H, J Comparison of subsets of CD45+ cells. K Gating strategy for detection of MAGE-A expressed by live tumor cells. L Positive rate of MAGE-A in tumor cells

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Translational Medicine Communications

ISSN: 2396-832X

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