Fig. 3

ROS production by neutrophils decreases during ATO treatment cycles but is increased compared to that in healthy donors. ROS production was measured as the area under the curve (AUC) over a time period of three hours (A). Neutrophils isolated from subjects undergoing treatment with ATO showed higher ROS production before treatment than those from healthy donors. There was also a decrease after four weeks of ATO treatment compared to before treatment. Correlation between ROS production and leukocyte count (B) and ANC (C) was tested using Pearson´s test of correlation showing an association between higher leukocyte counts, ANC and increased ROS production