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Fig. 1 | Translational Medicine Communications

Fig. 1

From: B-cell differentiation is pressuromodulated as determined by pressuromodulation mapping: Part I, cell differentiation

Fig. 1Fig. 1Fig. 1

Pressuromodulation map of B-cell differentiation stages. There are three completed maximal B-cell polarization periods with another to begin (CD40R+), two half-refractory B-cell polarization periods (CD40R±), and four full-refractory B-cell polarization periods (CD40R-) to the 1st generation CM VDJ (VJ)-IgG3+, IgG1+, IgHA1+, IgG4+, IgG2+ or IgE+ (excluding IgA2+) Evolved Mature naïve B-cell preparing to CSR further in the lymph node (2nd phase) after the completing the Immature B-cell phase in the myeloid bone marrow (1st phase). The antigen pressuromodulation effect-mediated extra-lymph nodal long-lived B-plasma cell/plasmablast secretory antibody phase (3rd phase) takes place in the periphery/tissue nidus. Note: The classical pathway B-cell maturation pressuromodulation map is shown, however the map applies to the parallel alternate B-cell maturation pathway wherein the T-cell independent antigen-mediated toll-like receptor (TLR) positive pressuromodulation effect (i.e. endocytic) substitutes for the CD4R+ CD40LG T-cell-mediated CD40R B-cell polarization pressuromodulation effect. †, upper esebssiwaagoTQ units range, 0.41–0.36. Black, CD40 at maximum cell polarization potential (CD40R+). Dark blue, CD40 at half-refractory (CD40R±). Light blue, CD40 at full-refractory (CD40R-). Thick black lined large rectangular box, extra-nodal secretory antibody phase

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