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Table 1 Chromosome 14 (−) strand chromatin Ig heavy chain locus immunoglobin gene esebssiwaagoTQs for germline genes in native 5′- > 3′ chronology before gene rearrangement

From: B-cell antibody class switchings are pressuromodulated events: Part II, gene recombination

Germline Genea

Germline gene locusa

Total no. of transcribed bases at gene locus or n/a (episode category)b

Initial no. of sub-episode blocks (converted final no. of sub-episode blocks, or n/a)

Germline gen e 2-digit (3-digit) esebssiwaagoTQ

Predicted gene recombination wrt allele 1 (IGHM), allele 2 (IGHD), both, or neither

IGHA2

IGHA2

1508 (3)

7 (n/a)

0.10 (0.099)

Allele 1;

Allele 2 after initial allelic exclusion

IGHE

ENSG00000227468/IGHE/ENSG00000254140

7667 (3)

7 (n/a)

0.11 (0.111)

Allele 1;

Allele 2 after initial allelic exclusion

IGHG4 & IGHG2

lnc-JAG2–1/IGHG4 /IGHG2/ ENSG00000253364

30,527 (2)

7 (5)

0.16 (0.163)

Allele 1;

Allele 2 after initial allelic exclusion

IGHA1

IGHA1

1548 (3)

7 (n/a)

0.13 (0.131)

Allele 1;

Allele 2 after initial allelic exclusion

IGHG1

IGHG1

6729 (3)

7 (n/a)

0.12 (0.120)

Allele 1;

Allele 2 after initial allelic exclusion

IGHG3

GC14M105753/IGHG3

20,987 (2)

7 (5)

0.08 (0.075)

Allele 1;

Allele 2 after initial allelic exclusion

IGHD

IGHD

8914 (3)

7 (n/a)

0.09 (0.092)

Allele 2 HR except in initial allelic exclusion

IGHM

IGHM

6729 (3)

7 (n/a)

0.09 (0.088)

Allele 1;

Allele 2 after initial allelic exclusion

MIR4539

MIR4539

60 (3)

7 (n/a)

0.08 (0.076)

iCSR for Allele 1 (IGHM); Allele 2 (IGHD) delayed iCSR after initial allelic exclusion

MIR4507 & MIR4538

MIR4507/ MIR4538

119 (3)

7 (n/a)

0.08 (0.081)

iCSR for Allele 1 (IGHM); Allele 2 (IGHD) delayed iCSR after initial allelic exclusion

MIR4537

MIR4537

70 (3)

7 (n/a)

0.06 (0.064)

iCSR for Allele 1 (IGHM); Allele 2 (IGHD) delayed iCSR after initial allelic exclusion

  1. aonly Ig genes and gene loci included, non-coding RNA genes (processed pseudogenes) excluded b >  11,864 ≤ 265,005 total transcribed bases, Episode category 2 gene; Episode category 3 gene bases, ≤ 11,864 total transcribed bases, Episode category 3 gene