Table 3 Chromosome 14 (−) strand chromatin Ig heavy chain locus diversity gene esebssiwaagoTQs for germline genes in native 5′- > 3′ chronology before gene rearrangement
From: B-cell antibody class switchings are pressuromodulated events: Part II, gene recombination
Germline Gene 1 nf | Germline gene locusa | Total no. of transcribed bases at gene locus or n/a (episode category)b | Initial no. of sub-episode blocks (converted final no. of sub-episode blocks, or n/a) | Germline gene 2-digit (3-digit) esebssiwaagoTQc | Predicted gene recombination wrt allele 1 (IGHM), allele 2 (IGHD), both, or neither |
|---|---|---|---|---|---|
IGHD7–27 c | IGHD7–27 | 11 (3) | 7 (n/a) | 0.17 (0.165)c | Neither allele 1 nor allele 2 |
IGHD1–26 | IGHD1–26 | 20 (3) | 7 (n/a) | 0.22 (0.217) | Allele 2 (D → J step 1 of 1 for IGHD) |
IGHD6–25 | IGHD6–25 | 18 (3) | 7 (n/a) | 0.17 (0.172) | Allele 2 (D → J step 1 of 1 for IGHD) |
IGHD5–24, IGHD4–23 & IGHD3–22 | lnc-BRF1–1 {IGHD5–24; IGHD4–23; IGHD3–22) | 2856 (3) | 7 (5) | 0.22 (0.216) | Allele 2 (D → J step 1 of 1 for IGHD) |
IGHD2–21 | IGHD2–21 | 28 (3) | 7 (n/a) | 0.20 (0.205) | Allele 2 (D → J step 1 of 1 for IGHD) |
IGHD1–20 nf | IGHD1–20 | 17 (3) | 7 (7) | 0.41 (0.406) | Allele 1 non-functional (D → J step 1 of 2 for IGHM) |
IGHD6–19 | IGHD6–19 | 21 (3) | 7 (5) | 0.31 (0.309) | Allele 1 (D → J step 2 of 2 for IGHM wrt IGHJ5-IGHD1–20) |
IGHD5–18 nf | IGHD5–18 | 20 (3) | 7 (4) | 0.25 (0.254) | Allele 2 non-functional (D → J step 1 of 2 for IGHD) |
IGHD4–17 | IGHD4–17 | 16 (3) | 7 (9) | 0.31 (0.310) | Allele 1 (D → J step 2 of 2 for IGHM wrt IGHJ5-IGHD1–20) |
IGHD3–16 | IGHD3–16 | 37 (3) | 7 (n/a) | 0.31 (0.308) | Allele 1 (D → J step 2 of 2 for IGHM wrt IGHJ5-IGHD1–20) |
IGHD2–15 | IGHD2–15 | 31 (3) | 7 (n/a) | 0.29 (0.294) | Allele 1 (D → J step 1 of 1 for IGHM |
IGHD1–14 | IGHD1–14 | 17 (3) | 7 (n/a) | 0.29 (0.292) | Allele 1 (D → J step 1 of 1 for IGHM |
IGHD6–13 | IGHD6–13 | 21 (3) | 7 (n/a) | 0.29 (0.286) | Allele 2 (D → J step 1 of 1 for IGHM |
IGHD5–12 | IGHD5–12 | 23 (3) | 7 (n/a) | 0.22 (0.218) | Allele 2 (D → J step 1 of 1 for IGHD) |
IGHD4–11 nf | IGHD4–11 | 16 (3) | 7 (n/a) | 0.29 (0.293) | Allele 2 non-functional (D → J step 1 of 2 for IGHD) |
IGHD3–10 | IGHD3–10 | 31 (3) | 7 (n/a) | 0.34 (0.342) | Allele 1 (D → J step 2 of 2 for IGHM wrt IGHJ5-IGHD1–20) |
IGHD3–9 | IGHD3–9 | 31 (3) | 7 (3) | 0.24 (0.239) | Allele 2 (D → J step 2 of 2 for IGHD wrt IGHJ2--IGHD4–11) |
IGHD2–8 | IGHD2–8 | 31 (3) | 7 (n/a) | 0.30 (0.295) | Allele 1 (D → J step 2 of 2 for IGHM wrt IGHJ5-IGHD1–20) |
IGHD1–7 | IGHD1–7 | 17 (3) | 7 (5) | 0.28 (0.276) | Allele 2 (D → J step 2 of 2 for IGHD wrt IGHJ2--IGHD4–11) |
IGHD6–6 | IGHD6–6 | 18 (3) | 7 (n/a) | 0.27 (0.275) | Allele 2 (D → J step 2 of 2 for IGHD wrt IGHJ2--IGHD4–11) |
IGHD5–5 | IGHD5–5 | 20 (3) | 7 (n/a) | 0.23 (0.233) | Allele 2 (D → J step 2 of 2 for IGHD wrt IGHJ2-IGHD5–18) |
IGHD4–4 | IGHD4–4 | 16 (3) | 7 (n/a) | 0.26 (0.258) | Allele 2 (D → J step 2 of 2 for IGHD wrt IGHJ2--IGHD4–11) |
IGHD3–3 | IGHD3–3 | 31 (3) | 7 (9) | 0.24 (0.243) | Allele 1 (D → J step 2 of 2 for IGHD wrt IGHJ2-IGHD4–11) |
IGHD2–2 | IGHD2–2 | 31 (3) | 7 (n/a) | 0.30 (0.301) | Allele 1 (D → J step 2 of 2 for IGHM wrt IGHJ5-IGHD1–20) |
IGHD1–1 | IGHD1–1 | 17 (3) | 7 (7) | 0.23 (0.233) | Allele 2 (D → J step 2 of 2 for IGHD wrt IGHJ2-IGHD5–18) |