Table 7 Chromosome 14 (−) strand chromatin Ig heavy chain locus recombination sequence for both alleles after IGHV1-3-IGHD_-_-IGHJ6
From: B-cell antibody class switchings are pressuromodulated events: Part II, gene recombination
Gene with respect to, or n/a | Gene (no. of transcribed gene bases, or n/a) | Total no. of transcribed bases at gene locus, or n/a (episode category)a, g3, g4g2, e | Initial no. of sub-episode blocks (converted final no. of sub-episode blocks, or n/a) | 2-digit esebssiwaagoTQ (and 3-digit) esebssiwaagoTQ | esebssiwaagoTQ match (yes, no)b,c | Match recombination gene for further recombination, location upstream & downstream of, or n/a |
|---|---|---|---|---|---|---|
n//a | V1–3-D_-_-J6 (n./a) | n/a (3) | 7 (9) | 0.23 (0.226) | yes | HR upstream of IGHD (Allele 2) |
V1–3- D_-_-J6 | MIR4537 (70) | 70 (3) | 7 (n/a) | 0.25 (0.251) | no | n/a |
V1–3- D_-_-J6 | MIR4507/MIR4538 (119) | 119 (3) | 7 (n/a) | 0.26 (0.260) | yes | iCSR with intergene bases of MIR4539 (Allele 1) |
V1–3- D_-_-J6 | MIR4539 (60) | 60 (3) | 7 (n/a) | 0.27 (0.268) | yes | iCSR with intergene bases of MIR4507 (Allele 1) |
V1–3- D_-_-J6 | IGHD (8914) | 8914 (3) | 7 (n/a) | 0.20 (0.198) | yes | HR downstream of IGHV1–3- IGHD_-_-IGHJ6 (Allele 2) |
n/a | V1–3-D_-_ -J6-IGHD (n/a) | 22,039 (2) | 5 (n/a) | 0.32 (0.320) | n/a | n/a |
n/a | V1–3-D_-_ -J6-IGHM (n/a) | 18,279 (2) | 5 (n/a) | 0.27 ( 0.275) | yes | upstream of IGHG3 & IGHA2 to upstream of IGHM CSRs |
V1–3-D_-_ -J6-IGHM | IGHG3 (5492) | 20,987g3 (2) | 5 (n/a) | 0.27 (0.271) | yes | primary CSR |
V1–3-D_-_ -J6-IGHM | IGHG1 (6729) | 6729 (3) | 7 (8) | 0.17 (0.173) | no | n/a |
V1–3-D_-_ -J6-IGHM | IGHA1 (1548) | 1548 (3) | 7 (9) | 0.22 (0.222) | no | n/a |
V1–3-D_-_ -J6-IGHM | IGHG4/ IGHG2 (1726; 1739) | 30,527g4g2 (2) | 5 (n/a) | 0.22 (0.215) | no | n/a |
V1–3-D_-_ -J6-IGHM | IGHE (1788) | 7667e (3) | 7 (9) | 0.22 (0.222) | no | n/a |
V1–3-D_-_ -J6-IGHM | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.26 (0.258) | yes | primary CSR (final) |
n/a | V1–3-D_-_ -J6-IGHG3 (n/a) | n/a (2) | 5 (4) | 0.31 (0.306) | yes | only upstream of IGHG4/IGHG2 to upstream of IGHG3 CSR |
V1–3-D_-_ -J6-IGHG3 | IGHG1 (6729) | 6729 (3) | 7 (n/a) | 0.19 (0.190) | no | n/a |
V1–3-D_-_ -J6-IGHG3 | IGHA1 (1548) | 1548 (3) | 7 (n/a) | 0.16 (0.161) | no | n/a |
V1–3-D_-_ -J6-IGHG3 | IGHG4/ IGHG2 (1726; 1739) | 30,527g4g2 (2) | 5 (n/a) | 0.33 (0.325) | yes | secondary CSR |
V1–3-D_-_ -J6-IGHG3 | IGHE (1788) | 7667 (3) | 7 (n/a) | 0.21 (0.211) | no | n/a |
V1–3-D_-_ -J6-IGHG3 | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.23 (0.226) | no | n/a |
─ | no V1–3-D_-_ -J6-IGHG1 | ─ | ─ | ─ | ─ | ─ |
no V1–3-D_-_ -J6-IGHG1 | IGHA1 (1548) | 1548 (3) | 7 (-) | n/a | n/a | tertiary CSR not applicable (n/a) |
no V1–3-D_-_ -J6-IGHG1 | IGHG4/ IGHG2 (1726; 1739) | 30,527g4g2 (2) | 5 (-) | n/a | n/a | tertiary CSR not applicable (n/a) |
no V1–3-D_-_ -J6-IGHG1 | IGHE (1788) | 7667 (3) | 7 (−) | n/a | n/a | tertiary CSR not applicable (n/a) |
no V1–3-D_-_ -J6-IGHG1 | IGHA2 (1508) | 1508 (3) | 7 (−) | n/a | n/a | tertiary CSR not applicable (n/a) |
─ | no V1–3-D_-_ -J6-IGHA1 | ─ | ─ | ─ | ─ | ─ |
no V1–3-D_-_ -J6-IGHA1 | IGHG4/ IGHG2 (1726; 1739) | 30,527g4g2 (2) | 5 (-) | n/a | n/a | tertiary CSR not applicable (n/a) |
no V1–3-D_-_ -J6-IGHA1 | IGHE (1788) | 7667e (3) | 7 (−) | n/a | n/a | tertiary CSR not applicable (n/a) |
no V1–3-D_-_ -J6-IGHA1 | IGHA2 (1508) | 1508 (3) | 7 (−) | n/a | n/a | tertiary CSR not applicable (n/a) |
n/a | V1–3-D_-_ -J6-IGHG4 (n/a) | n/a (2) | 5 (5) | 0.24 (0.237) | yes | upstream of IGHE & IGHA2 to upstream of IGHG4 CSR |
V1–3-D_-_ -J6-IGHG4 | IGHE (1788) | 7667 (3) | 7 (n/a) | 0.19 (0.187) | no | n/a |
V1–3-D_-_ -J6-IGHG4 | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.23 (0.226) | yes | tertiary CSR (final) |
─ | no V1–3-D_-_ -J6-IGHE | ─ | ─ | ─ | ─ | ─ |
no V1–3-D_-_ -J6-IGHE | IGHA2 (1508) | 1508 (3) | 7 (−) | n/a | n/a | quaternary CSR not applicable (n/a) |
n/a | V1–3-D_-_ -J6-IGHA2 (n/a) | n/a (2) | 5 (7) | 0.18 (0.185) | n/a | n/a |