Table 9 Chromosome 14 (−) strand chromatin Ig heavy chain locus recombination sequence for both alleles after IGHV5–51-IGHD_-_-IGHJ6
From: B-cell antibody class switchings are pressuromodulated events: Part II, gene recombination
Gene with respect to, or n/a | Gene (no. of transcribed gene bases, or n/a) | Total no. of transcribed bases at gene locus, or n/a (episode category)a, g3, g4g2, e | Initial no. of sub-episode blocks (converted final no. of sub-episode blocks, or n/a) | 2-digit esebssiwaagoTQ (and 3-digit) esebssiwaagoTQ | esebssiwaagoTQ match (yes, no)b,c | Match recombination gene for further recombination, location upstream & downstream of, or n/a |
|---|---|---|---|---|---|---|
n//a | V5–51- D_-_-J6 (n/a) | n/a (2) | 5 (n/a) | 0.23 (0.233) | no | n/a |
V5–51- D_-_-J6 | MIR4537 (70) | 70 (3) | 7 (n/a) | 0.15 (0.152) | yes | iCSR with intergene bases of MIR4507/ MIR4538 (Allele 1) |
V5–51- D_-_-J6 | MIR4507/MIR4538 (119) | 119 (3) | 7 (n/a) | 0.15 (0.155) | yes | iCSR with intergene bases of MIR4537 (Allele 1) |
V5–51- D_-_-J6 | MIR4539 (60) | 60 (3) | 7 (n/a) | 0.16 (0.159) | no | n/a |
V5–51- D_-_-J6 | IGHD (8914) | 8914 (3) | 7 (9) | 0.17 (0.169) | yes | initial allelic exclusion (Allele 2) |
n/a | V5–51-D_-_-J6-IGHM (n/a) | n/a (2) | 5 (n/a) | 0.16 (0.165) | yes | upstream of IGHG1, IGHA1, IGHG4/IGHG2, IGHE & IGHA2 to upstream of IGHM CSRs |
V5–51-D_-_ -J6-IGHM | IGHG3 (5492) | 20,987g3 (2) | 5 (n/a) | 0.22 (0.215) | no | n/a |
V5–51-D_-_ -J6-IGHM | IGHG1 (6729) | 6729 (3) | 7 (n/a) | 0.16 (0.160) | yes | primary CSR |
V5–51-D_-_ -J6-IGHM | IGHA1 (1548) | 1548 (3) | 7 (n/a) | 0.18 (0.180) | yes | primary CSR |
V5–51-D_-_ -J6-IGHM | IGHG4/ IGHG2 (1726; 1739) | 30,527g4g2 (2) | 5 (n/a) | 0.19 (0.189) | yes | primary CSR |
V5–51-D_-_ -J6-IGHM | IGHE (1788) | 7667e (3) | 7 (n/a) | 0.13 (0.130) | no | n/a |
V5–51-D_-_ -J6-IGHM | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.18 (0.175) | yes | primary CSR (final) |
─ | no V5–51-D_-_ -J6-IGHG3 | ─ | ─ | ─ | ─ | ─ |
no V5–51-D_-_ -J6-IGHG3 | IGHG1 (6729) | 6729 (3) | 7 (-) | n/a | n/a | secondary CSR not applicable (n/a) |
no V5–51-D_-_ -J6-IGHG3 | IGHA1 (1548) | 1548 (3) | 7 (-) | n/a | n/a | secondary CSR not applicable (n/a) |
no V5–51-D_-_ -J6-IGHG3 | IGHG4/ IGHG2 (1726; 1739) | 30,527g4g2 (2) | 5 (-) | n/a | n/a | secondary CSR not applicable (n/a) |
no V5–51-D_-_ -J6-IGHG3 | IGHE (1788) | 7667 (3) | 7 (−) | n/a | n/a | secondary CSR not applicable (n/a) |
no V5–51-D_-_ -J6-IGHG3 | IGHA2 (1508) | 1508 (3) | 7 (−) | n/a | n/a | secondary CSR not applicable (n/a) |
n/a | V5–51-D_-_ -J6-IGHG1 (n/a) | n/a (2) | 5 (n/a) | 0.15 (0.153) | yes | upstream of IGHA1, IGHG4, IGHE & IGHA2 to upstream of IGHG1 CSRs |
V5–51-D_-_ -J6-IGHG1 | IGHA1 (1548) | 1548 (3) | 7 (n/a) | 0.17 (0.166) | yes | secondary CSR |
V5–51-D_-_ -J6-IGHG1 | IGHG4/ IGHG2 (1726; 1739) | 30,527 (2) | 5 (7) | 0.14 (0.137) | yes | secondary CSR |
V5–51-D_-_ -J6-IGHG1 | IGHE (1788) | 7667 (3) | 7 (n/a) | 0.14 (0.145) | yes | secondary CSR |
V5–51-D_-_ -J6-IGHG1 | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.16 (0.157) | yes | secondary CSR (final) |
n/a | V5–51-D_-_ -J6-IGHA1 (n/a) | n/a (2) | 5 (n/a) | 0.13 (0.134) | yes | upstream of IGHG4, IGHE & IGHA2 to upstream of IGHA1 CSRs |
V5–51-D_-_ -J6-IGHA1 | IGHG4/ IGHG2 (1726; 1739) | 30,527 (2) | 5 (n/a) | 0.11 (0.106) | yes | tertiary CSR |
V5–51-D_-_ -J6-IGHA1 | IGHE (1788) | 7667 (3) | 7 (n/a) | 0.15 (0.153) | yes | tertiary CSR |
V5–51-D_-_ -J6-IGHA1 | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.16 (0.163) | yes | tertiary CSR (final) |
n/a | V5–51-D_-_ -J6-IGHG4 (n/a) | n/a (2) | 5 (n/a) | 0.18 (0.184) | no | no |
V5–51-D_-_ -J6-IGHG4 | IGHE (1788) | 7667 (3) | 7 (n/a) | 0.15 (0.146) | no | no quaternary CSR with V5–51-DJ6-IGHG4 |
V5–51-D_-_ -J6-IGHG4 | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.15 (0.153) | no | no quaternary CSR with V5–51-DJ6-IGHG4 |
n/a | V5–51-D_-_ -J6-IGHE (n/a) | n/a (2) | 5 (6) | 0.15 (0.152) | yes | upstream of IGHA2 to upstream of IGHE CSR |
V5–51-D_-_ -J6-IGHE | IGHA2 (1508) | 1508 (3) | 7 (n/a) | 0.13 (0.129) | yes | quaternary CSR (final) |
n/a | V5–51-D_-_ -J6-IGHA2 (n/a) | n/a (2) | 5 (n/a) | 0.15 (0.148) | n/a | n/a |