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Table 4 Univariate and multivariate analysis of SHBG genotypes association with RPLa

From: Common genetic variants in the sex hormone-binding globulin (SHBG) gene in idiopathic recurrent pregnancy loss: a case control study

 

Univariate

Multivariate

 

1/2 b

2/2

1/2

2/2

SNP

P

OR (95% CI)

P

OR (95% CI)

P

aOR c (95% CI)

P

aOR (95% CI)

rs9898876

0.46

1.56 (0.49–5.02)

0.26

1.87 (0.63–5.58)

0.34

1.78 (0.54–5.87)

0.20

2.07 (0.69–6.23)

rs13894

0.65

0.89 (0.54–1.48)

0.61

0.88 (0.53–1.45)

0.84

0.95 (0.57–1.59)

0.77

0.93 (0.56–1.55)

rs858521

0.01

1.72 (1.13–2.60)

0.07

1.53 (0.96–2.44)

0.007

1.80 (1.17–2.77)

0.05

1.60 (1.00–2.58)

rs1799941

0.19

1.94 (0.72–5.25)

0.19

1.92 (0.73–5.08)

0.16

2.15 (0.75–6.16)

0.19

1.99 (0.71–5.57)

rs6257

0.85

0.93 (0.44–1.99)

0.11

0.56 (0.27–1.14)

0.68

0.84 (0.38–1.89)

0.07

0.50 (0.23–1.06)

rs6259

0.03

15.75 (1.29–192.46)

0.11

6.42 (0.66–62.33)

0.03

16.08 (1.28–202.08)

0.11

6.42 (0.65–63.70)

rs727428

0.70

0.83 (0.32–2.17)

0.61

0.77 (0.28–1.10)

0.67

0.81 (0.31–2.13)

0.59

0.76 (0.28–2.08)

  1. aHomozygous major allele genotypes were taken as reference (OR = 1.00)
  2. bGenotypes were coded as per “1” = major allele, “2” = minor allele
  3. caOR = adjusted odds ratios; BMI and age were the main covariates that were controlled for
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Translational Medicine Communications

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