Fig. 3

Changes in serum total aceneuramic acid concentrations measurement (Trial-1). In Trial-1, total aceneuramic acid that is aceneuramic acid combined with protein or lipid as well as free aceneuramic acid was measured. Since physiologically existing total aceneuramic acid is also measured, no increase in the concentration after administration was observed in each case. a. Single administration trial for each individual subject (subject numbers 1 to 3). -24 to 0 h (un-administered), 0 to 24 h (administered). b. Average of A. mean changes ± standard deviation, n = 3 for each group. c. Three-times-per-day administration trial for each individual subject (subject numbers 4 to 6). -24 to 0 h (un-administered), 0 to 24 h (administered). d. Average of C. mean changes ± standard deviation, n = 3 for each group. e. Three-times-per-day administration for 5-day trial for each individual subject (subject numbers 2, 4 and 6). - 1 to 0 Day (un-administered), 0 to 5 Day (administered). f. Average of E. mean changes ± standard deviation, n = 3 for each group