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Fig. 6 | Translational Medicine Communications

Fig. 6

From: Phase I clinical trial results of aceneuramic acid for GNE myopathy in Japan

Fig. 6

Changes in urinary free and total aceneuramic acid (Trial-2). Urine was collected in periods of − 24 to 20 h and - 20 to 0 h (before administration), 0 to 4 h and 4 to 24 h (after administration). Both free and total aceneuramic acid concentration in urine were measured. The amount of urinary excretion was calculated from urine concentration and its volume. The amount of free aceneuramic acid excretion in 24 h increased after administration. Also the amount of total aceneuramic acid excretion in 24 h roughly increased. a. Free aceneuramic acid with single administration (subject numbers 1 to 3, three times per day administration (subject numbers 4, 5, 7). b. Total aceneuramic acid with single administration (subject numbers 1 to 3, three-times-per day administration (subject numbers 4, 5, 7). c. Free aceneuramic acid with three-times-per-day for 7-day administration (subject numbers 1,3,4). d. Total aceneuramic acid with three-times-per-day for 7 days administration (subject numbers 1,3,4). BF: before administration, AF: after administration, D1: Day 1 of administration,D 7: Day 7 of administration

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