TY - JOUR AU - Artavanis-Tsakonas, S. AU - Rand, M. D. AU - Lake, R. J. PY - 1999 DA - 1999// TI - Notch signalling: cell fate control and signal integration in development JO - Science VL - 284 UR - https://doi.org/10.1126/science.284.5415.770 DO - 10.1126/science.284.5415.770 ID - Artavanis-Tsakonas1999 ER - TY - JOUR AU - Somasundaram, R. AU - Prasad, M. A. J. AU - Ungerbäck, J. AU - Sigvardsson, M. PY - 2015 DA - 2015// TI - Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia JO - Blood VL - 126 UR - https://doi.org/10.1182/blood-2014-12-575688 DO - 10.1182/blood-2014-12-575688 ID - Somasundaram2015 ER - TY - JOUR AU - Wang, H. AU - Zang, C. AU - Taing, L. AU - Arnett, K. L. AU - Wong, Y. J. AU - Pear, W. S. PY - 2014 DA - 2014// TI - NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers JO - Proc Natl Acad Sci VL - 111 UR - https://doi.org/10.1073/pnas.1315023111 DO - 10.1073/pnas.1315023111 ID - Wang2014 ER - TY - JOUR AU - Guruharsha, K. G. AU - Kankel, M. W. AU - Artavanis-Tsakonas, S. PY - 2012 DA - 2012// TI - The Notch signalling system: recent insights into the complexity of a conserved pathway JO - Nat Rev Genet VL - 13 UR - https://doi.org/10.1038/nrg3272 DO - 10.1038/nrg3272 ID - Guruharsha2012 ER - TY - JOUR AU - Taghon, T. N. AU - David, E. -. S. AU - Zuniga-Pflucker, J. C. AU - Rothenberg, E. V. PY - 2005 DA - 2005// TI - Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling JO - Genes Dev VL - 19 UR - https://doi.org/10.1101/gad.1298305 DO - 10.1101/gad.1298305 ID - Taghon2005 ER - TY - JOUR AU - Osborne, B. A. AU - Minter, L. M. PY - 2007 DA - 2007// TI - Notch signalling during peripheral T-cell activation and differentiation JO - Nat Rev Immunol VL - 7 UR - https://doi.org/10.1038/nri1998 DO - 10.1038/nri1998 ID - Osborne2007 ER - TY - JOUR AU - Koyanagi, A. AU - Sekine, C. AU - Yagita, H. PY - 2012 DA - 2012// TI - Expression of Notch receptors and ligands on immature and mature T cells JO - Biochem Biophys Res Commun VL - 418 UR - https://doi.org/10.1016/j.bbrc.2012.01.106 DO - 10.1016/j.bbrc.2012.01.106 ID - Koyanagi2012 ER - TY - JOUR AU - Radtke, F. AU - MacDonald, H. R. AU - Tacchini-Cottier, F. PY - 2013 DA - 2013// TI - Regulation of innate and adaptive immunity by Notch JO - Nat Rev Immunol VL - 13 UR - https://doi.org/10.1038/nri3445 DO - 10.1038/nri3445 ID - Radtke2013 ER - TY - JOUR AU - Pear, W. S. AU - Aster, J. C. AU - Scott, M. L. AU - Hasserjian, R. P. AU - Soffer, B. AU - Sklar, J. PY - 1996 DA - 1996// TI - Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles JO - J Exp Med VL - 183 UR - https://doi.org/10.1084/jem.183.5.2283 DO - 10.1084/jem.183.5.2283 ID - Pear1996 ER - TY - JOUR AU - Breit, S. PY - 2006 DA - 2006// TI - Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia JO - Blood VL - 108 UR - https://doi.org/10.1182/blood-2005-12-4956 DO - 10.1182/blood-2005-12-4956 ID - Breit2006 ER - TY - JOUR AU - Mirandola, L. AU - Comi, P. AU - Cobos, E. AU - Martin Kast, W. AU - Chiriva-Internati, M. AU - Chiaramonte, R. PY - 2011 DA - 2011// TI - Notch-ing from T-cell to B-cell lymphoid malignancies JO - Cancer Lett VL - 308 UR - https://doi.org/10.1016/j.canlet.2011.05.009 DO - 10.1016/j.canlet.2011.05.009 ID - Mirandola2011 ER - TY - JOUR AU - Tohda, S. AU - Kogoshi, H. AU - Murakami, N. AU - Sakano, S. AU - Nara, N. PY - 2005 DA - 2005// TI - Diverse effects of the Notch ligands Jagged1 and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells JO - Exp Hematol VL - 33 UR - https://doi.org/10.1016/j.exphem.2005.01.010 DO - 10.1016/j.exphem.2005.01.010 ID - Tohda2005 ER - TY - JOUR AU - Fabbri, G. AU - Rasi, S. AU - Rossi, D. AU - Trifonov, V. AU - Khiabanian, H. AU - Ma, J. PY - 2011 DA - 2011// TI - Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation JO - J Exp Med VL - 208 UR - https://doi.org/10.1084/jem.20110921 DO - 10.1084/jem.20110921 ID - Fabbri2011 ER - TY - STD TI - Hernandez Tejada FN, Galvez Silva JR, Zweidler-McKay PA. The challenge of targeting Notch in hematologic malignancies. Front Pediatr. 2014;2(54) https://doi.org/10.3389/fped.2014.00054. ID - ref14 ER - TY - JOUR AU - Andersson, E. m. m. a. R. AU - Lendahl, U. r. b. a. n. PY - 2014 DA - 2014// TI - Therapeutic modulation of Notch signalling — are we there yet? JO - Nature Reviews Drug Discovery VL - 13 UR - https://doi.org/10.1038/nrd4252 DO - 10.1038/nrd4252 ID - Andersson2014 ER - TY - JOUR AU - Peixoto, A. AU - Monteiro, M. AU - Rocha, B. AU - Veiga-Fernandes, H. PY - 2004 DA - 2004// TI - Quantification of multiple gene expression in individual cells JO - Genome Res VL - 14 UR - https://doi.org/10.1101/gr.2890204 DO - 10.1101/gr.2890204 ID - Peixoto2004 ER - TY - JOUR AU - Sciacca, S. AU - Pilato, M. AU - Mazzoccoli, G. AU - Pazienza, V. AU - Vinciguerra, M. PY - 2013 DA - 2013// TI - Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease JO - Heart Vessel VL - 28 UR - https://doi.org/10.1007/s00380-012-0238-5 DO - 10.1007/s00380-012-0238-5 ID - Sciacca2013 ER - TY - JOUR AU - Hayashi, Y. AU - Osanai, M. AU - Lee, G. -. H. PY - 2015 DA - 2015// TI - NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells JO - Oncol Rep VL - 34 UR - https://doi.org/10.3892/or.2015.4171 DO - 10.3892/or.2015.4171 ID - Hayashi2015 ER - TY - JOUR AU - Koipally, J. AU - Renold, A. AU - Kim, J. AU - Georgopoulos, K. PY - 1999 DA - 1999// TI - Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes JO - EMBO J VL - 18 UR - https://doi.org/10.1093/emboj/18.11.3090 DO - 10.1093/emboj/18.11.3090 ID - Koipally1999 ER - TY - STD TI - Kathrein KL, Chari S, Winandy S. Ikaros directly represses the Notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation. J Biol Chem. 2008;283(16):10476–84. ID - ref20 ER - TY - JOUR AU - Gulino, A. AU - Di Marcotullio, L. AU - Screpanti, I. PY - 2010 DA - 2010// TI - The multiple functions of Numb JO - Exp Cell Res VL - 316 UR - https://doi.org/10.1016/j.yexcr.2009.11.017 DO - 10.1016/j.yexcr.2009.11.017 ID - Gulino2010 ER - TY - JOUR AU - Kannan, S. AU - Fang, W. AU - Song, G. AU - Mullighan, C. G. AU - Hammitt, R. AU - McMurray, J. AU - Zweidler-McKay, P. A. PY - 2011 DA - 2011// TI - Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression JO - Blood VL - 117 UR - https://doi.org/10.1182/blood-2009-12-253419 DO - 10.1182/blood-2009-12-253419 ID - Kannan2011 ER - TY - JOUR AU - McKercher, S. R. AU - Torbett, B. E. AU - Anderson, K. L. AU - Henkel, G. W. AU - Vestal, D. J. AU - Baribault, H. PY - 1996 DA - 1996// TI - Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities JO - EMBO J VL - 15 UR - https://doi.org/10.1002/j.1460-2075.1996.tb00949.x DO - 10.1002/j.1460-2075.1996.tb00949.x ID - McKercher1996 ER - TY - JOUR AU - Ernst, P. AU - Fisher, J. K. AU - Avery, W. AU - Wade, S. AU - Foy, D. AU - Korsmeyer, S. J. PY - 2004 DA - 2004// TI - Definitive hematopoiesis requires the mixed-lineage leukemia gene JO - Dev Cell VL - 6 UR - https://doi.org/10.1016/S1534-5807(04)00061-9 DO - 10.1016/S1534-5807(04)00061-9 ID - Ernst2004 ER - TY - JOUR AU - Cs, C. AU - Schebesta, A. AU - Delogu, A. AU - Busslinger, M. PY - 2007 DA - 2007// TI - Pax5: the guardian of B cell identity and function JO - Nat Immunol VL - 8 UR - https://doi.org/10.1038/ni1454 DO - 10.1038/ni1454 ID - Cs2007 ER - TY - JOUR AU - Rosati, E. AU - Sabatini, R. AU - Rampino, G. AU - Tabilio, A. AU - Di Ianni, M. AU - Fettucciari, K. PY - 2009 DA - 2009// TI - Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells JO - Blood VL - 113 UR - https://doi.org/10.1182/blood-2008-02-139725 DO - 10.1182/blood-2008-02-139725 ID - Rosati2009 ER - TY - JOUR AU - Gianfelici, V. PY - 2012 DA - 2012// TI - Activation of the NOTCH1 pathway in chronic lymphocytic leukemia JO - Haematologica VL - 97 UR - https://doi.org/10.3324/haematol.2012.061721 DO - 10.3324/haematol.2012.061721 ID - Gianfelici2012 ER - TY - JOUR AU - Weng, A. P. AU - Ferrando, A. A. AU - Lee, W. AU - Morris, J. P. AU - Silverman, L. B. AU - Sanchez-Irizarry, C. PY - 2004 DA - 2004// TI - Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia JO - Science VL - 306 UR - https://doi.org/10.1126/science.1102160 DO - 10.1126/science.1102160 ID - Weng2004 ER -