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Fig. 1 | Translational Medicine Communications

Fig. 1

From: The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation

Fig. 1

Representative UTE MRI images generated from detection of ferumoxytol flowing through vessels of mice in the disturbed flow conditioned experimental cohort, with blue circles indicating the RCAs and red circles indicates the LCAs. a Shows ferumoxytol-marked vascular structure of mice at day 1 post-ligation surgery. b The structure of visible vasculature is identified, revealed by ferumoxytol contrast, after 5 days post-ligation surgery. c The vascular integrity of the mouse after 7 days post-LCA ligation surgery is shown, as indicated by ferumoxytol contrast. Over time, reduction of detectable ferumoxytol in of the LCA suggests minimal blood flow, which would correspond to lower shear stress along the wall of the LCA. Additionally, there appears to be progressive remodeling of LCA vessel diameter and surrounding vessels, suggesting an inflammatory response, which is to be confirmed in the present study

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