Fig. 4

Expression pattern and Hierarchical clustering of Ikaros in the assessed pathologies. (a) Expression pattern of Ikaros in the assessed pathologies: RA, rheumatoid arthritis; SSc, systemic sclerosis; SLE, systemic lupus erythaematosus; SS, Sjögren’s syndrome. (b) Hierarchical clustering of Ikaros differential expression. Rows represent cases of RA, SLE, SS, SSc and controls, and columns refer to the log₂ relative expression data and the absence or presence of non-canonical splicing. The expression levels are represented using a colour code with red and green corresponding to high and low expression, respectively, and the intensity refers to the magnitude of the deviation from the mean. The presence of non-canonical splicing is represented as “YES” and its absence as “NO”