Skip to main content

Table 1 Localization of different sirtuins and their enzymatic actions

From: Sirtuins and diabetes: optimizing the sweetness in the blood

SIRTUINS

FUNCTIONS

LOCALIZATION

ENZYMATIC ACTION

SIRT1

Cell survival, Metabolism, DNA damage repair, Lipid and glucose homeostasis, Stress resistance, Insulin secretion, Inflammation, Neurodegeneration/Axonal degeneration, Apoptosis, Cancer, Lifespan, Cardiovascular disorder

Nucleus, cytosol

Deacetylase

SIRT2

Control cell cycle, Cell motility/Tumorigenesis, cell differentiation, Genome stability, Stress response, Neurodegeneration, Metabolism

Cytosol, Nucleus

Deacetylase, Demyristoylation

SIRT3

Thermogenesis, Metabolism, Lifespan, Oxidative stress, cell apoptosis

Mitochondria, Nucleus

Deacetylase

SIRT4

Insulin secretion, TCA cycle, Fatty acid oxidation, tumour, genome stability

Mitochondria

ADP-ribosylation, deacetylase

SIRT5

Urea cycle, ketone body synthesis, oxidative stress, cellular respiration

Mitochondria

Deacetylase, demalonylation, desuccinylation

SIRT6

DNA repair, glucose homeostasis, Genome stability, Metabolism, inflammation, cancer, cardiovascular diseases

Nucleus

Deacetylase, ADP-ribosylation, demyristoylation

SIRT7

rRDNA transcription, genome stability, oxidative stress

Nucleus

Deacetylation