From: Sirtuins and diabetes: optimizing the sweetness in the blood
SIRTUINS | FUNCTIONS | LOCALIZATION | ENZYMATIC ACTION |
---|---|---|---|
SIRT1 | Cell survival, Metabolism, DNA damage repair, Lipid and glucose homeostasis, Stress resistance, Insulin secretion, Inflammation, Neurodegeneration/Axonal degeneration, Apoptosis, Cancer, Lifespan, Cardiovascular disorder | Nucleus, cytosol | Deacetylase |
SIRT2 | Control cell cycle, Cell motility/Tumorigenesis, cell differentiation, Genome stability, Stress response, Neurodegeneration, Metabolism | Cytosol, Nucleus | Deacetylase, Demyristoylation |
SIRT3 | Thermogenesis, Metabolism, Lifespan, Oxidative stress, cell apoptosis | Mitochondria, Nucleus | Deacetylase |
SIRT4 | Insulin secretion, TCA cycle, Fatty acid oxidation, tumour, genome stability | Mitochondria | ADP-ribosylation, deacetylase |
SIRT5 | Urea cycle, ketone body synthesis, oxidative stress, cellular respiration | Mitochondria | Deacetylase, demalonylation, desuccinylation |
SIRT6 | DNA repair, glucose homeostasis, Genome stability, Metabolism, inflammation, cancer, cardiovascular diseases | Nucleus | Deacetylase, ADP-ribosylation, demyristoylation |
SIRT7 | rRDNA transcription, genome stability, oxidative stress | Nucleus | Deacetylation |