Label-free serum proteomics and multivariate data analysis identifies biomarkers and expression trends that differentiate Intraductal papillary mucinous neoplasia from pancreatic adenocarcinoma and healthy controls

Table 2 Biomarker panels. This table presents the biomarker panels for each comparison. Accession number, ANOVA p value, fold change, S-Plot parameters values (p(Corr) [1]) and area under the curve (AUC) from ROC curve is given here. 95% confidence interval (CI) and standard error is also shown

Primary accession	Anova p-value	Fold change	Highest mean	Lowest mean	Description	p [1]	p(corr) [1]	AUC	95% CI	SE
Control Vs Low-Grade IPMN
P01042	2.58E-05	1.26	Low Grade	Control	Kininogen-1	0.23	0.78	0.95	0.872–1.036	0.041
P10909	0.0018	1.20	Low Grade	Control	Clusterin	0.13	0.72	0.85	0.703–1.011	0.078
Control Vs High-Grade IPMN
P01042	4.24E-05	1.30	High Grade	Control	Kininogen-1	0.28	0.75	0.93	0.823–1.050	0.058
Control Vs Pancreatic Carcinoma
P48740	0.031	1.19	Control	Carcinoma	Mannan-binding lectin serine protease 1	0.10	0.75	0.72	0.541–0.905	0.092
P02656	0.005	1.49	Control	Carcinoma	Apolipoprotein C-III	0.12	0.72	0.80	0.635–0.965	0.083
P04083	1.40E-05	1.32	Carcinoma	Control	Annexin A1	−0.11	−0.74	0.91	0.820–1.016	0.050
Low-Grade IPMN Vs Pancreatic Carcinoma
P48740	0.0131	1.20	Low Grade	Carcinoma	Mannan-binding lectin serine protease 1	0.10	0.75	0.73	0.565–0.914	0.089
P27169	0.0036	1.31	Low Grade	Carcinoma	Serum paraoxonase/arylesterase 1	0.22	0.70	0.79	0.629–0.957	0.083
P02753	0.0005	1.45	Low Grade	Carcinoma	Retinol-binding protein 4	0.12	0.70	0.84	0.708–0.984	0.070

ISSN: 2396-832X