Endogenous fluorescence of hemosiderin in endometriosis to improve clinical detection

Cabe, Andrew G.; Estrada, Arnold D.; Hoyt, Taylor; Yang, Xiao; Jenney, Scott; Valente, Philip T.; Cox, Bryan; McLaughlin, Jessica E.; Robinson, Randal D.; Milner, Thomas E.; Feldman, Marc D.

doi:10.1186/s41231-019-0038-3

Translational Medicine Communications

Table 3 Full Imaging Results

From: Endogenous fluorescence of hemosiderin in endometriosis to improve clinical detection

Subject	Sample	Subsec.	CI	Type	Path.	TPM-hemo	OCT-glands
20	1		Yes	Red	H	Yes
	2		Yes	Red	H	Yes
	3	b	Yes	Red	H,S	Yes
	4	b	Yes	Dark chocolate cyst	H	Yes
		c	Yes		S	No
	5	a	Yes	Cyst	H	Yes
		c	Yes		H,S	Yes
		d	Yes		H	Yes
	6		Yes	Endometroma	H	Yes
22	1	a	Yes	Red+black	–	No
		b	Yes		G,S	No	No
	2		No	Control	–	No
23	1		No	Control	–	No
	2	a	Yes	Red	–	No
	3	a	Yes	red	–	No
		b	Yes		–	No
	4	b	Yes	Black+white	–	No
24	1	a	Yes	Red	–	No
		b	Yes		–	No
	2		Yes	Black + white	–	No
	3		No	Control	–	No
25	1	a	Yes	Red	S	No
		b	Yes		G,S	No	No
	2	a	Yes	Black	H,S	Yes
		b	Yes		H,S	Yes
	3		No	Control	–	No
27	1	a	Yes	Red + black	G,S	No	Yes
		b	Yes		–	No
	2		Maybe	White	–	No
	3		No	Control	–	No
	4	a	Yes	Endometroma	H	Yes
		b	Yes		H,S	Yes
		c	Yes		H	Yes
	5		Yes	Black	H	Yes
	6		Yes	Red	–	No
28	1		Maybe	White	–	No
	2	a	Yes	Red	H	Yes
		b	Yes		–	No
		c	Yes		H	Yes
	3	a	Yes	Red	–	No
		b	Yes		–	No
		c	Yes		–	No
	4		No	Control	–	No
29	1	a	Yes	Red	G,H,S	Yes	Yes
		b	Yes		G,H,S	Yes	Yes
	2		No	Control	–	No
	3	a	Yes	Red + black	–	No
		b	Yes		G,H,S	Yes	Yes
	4		Maybe	Black	–	No
30	1		Yes	Black	H	Yes
	2		maybe	White	–	No
	3	a	Yes	Black	H	Yes
		b	Yes		H	Yes
	4		Yes		E, H	Yes
	5	a	Yes		H	Yes
		b	Yes		E,H	Yes
	7		No	Control	–	No
32	1		Yes	Red	G,H,S	Yes	Yes
	2		Yes	Red	G,H,S	Yes	Yes
	3		Maybe	Black	E,H,S	Yes
	4		Maybe	White	G,H,S	Yes	Yes
	5		No	Control	–	No
34	1		Yes	Black	G,H,S	Yes	Yes
	2	a	Yes	Red	G,H,S	Yes	Yes
		b	Yes		G,S	No	Yes
	3		Maybe	White	H, S	Yes
	4		No	Control	–	No
36	1		No	Control	–	No
	2	a	Maybe	Black	H,S	Yes
		b	Maybe		–	No
	3	a	Yes	Red	G,S	No	No
		b	Yes		E,H,S	Yes
	4		Maybe	Black + white	H,S	Yes
38	1		Yes	Red	G,S	No	Yes
	2		Yes	Red	–	No
	3		Yes	Black	–	No
	4		Maybe	White	H	Yes
	5		No	Control	–	No
	6		Maybe	White	–	No
39	1		Yes		S	No
	2		Maybe		–	No
	3		No	Control	–	No
	4		Maybe		–	No
	5	a	Yes		H,S	Yes
		b	Yes		H	Yes
		c	Yes		–	No
		d	Yes		–	No
42	1		No		–	No
	2		Maybe		–	No
	3		Yes		–	No
	4	a	Maybe		G, H, S	Yes	Yes
		b	Maybe		–	No
	5		Yes		G, S	No	Yes
	6		Yes		G, H, S	Yes	Yes
	7		Yes		G, S	No	Yes
45	1		Maybe		–	No
	2		Maybe		H, S	Yes
	3		Yes		G, S	No	Yes
	4		Yes		–	No
	5		Yes		–	No
	6		No		–	No
46	1		Yes		H	Yes
	2	a	Yes		–	No
		b	Yes		–	No
	3	a	Yes		G, H, S	Yes	Yes
	4		No		–	No
47	1		Maybe		G, S	No	Yes
	2		Yes		G, H, S	Yes	No
	3		Yes		G, H, S	Yes	Yes
	5		Yes		–	No
	6		Maybe		–	No
	7		Yes		H, S	Yes
	8		No		–	No

Columns: Subject: Subject number, Sample: sample number from that subject, Subsec.: is the subsection if the sample had to be divided to be fully imaged due to sample size, CI (Clinical Impression): yes is positive for endo, maybe is possible endometriosis normally at the surgeon’s discretion for removal, no is control tissue, Type: the surgeon reading of type of endometriosis, Path: Pathology reading - G is gland, fluid filled sac, E is endothelial cells with no fluid filled sac, H is hemosiderin, and S is stroma. TPM-hemo: yes is a present optical marker for hemosiderin, no is no optical marker as determined from the TPM image, OCT-glands: yes if the glands is seen and co-registered between the OCT image and histology, no if no such co-registration was possible

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ISSN: 2396-832X

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