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Table 1 The S-plot proteins differing between samples from patients with right-sided stage II and III CRC

From: Differences and overlap in plasma protein expression during colorectal cancer progression

Accession

Peptide count

Unique peptides

Confidence score

Mann-Whitney U test p-value

Fold change (right colon stage II/right colon III)

Protein name

Gene name

p [1]

p (corr) [1]

O95568

8

3

32,4

4,37E−05

1,6

Histidine protein methyltransferase 1 homolog

METTL18

−0,02

−0,86

P09429

5

2

29,5

1,43E− 04

1,8

High mobility group protein B1

HMGB1

−0,03

− 0,82

P68032;P62736;P68133;P63267

21

3

208,1

1,66E−03

1,8

Actin_ alpha cardiac muscle 1

ACTC1

−0,04

−0,82

P01344

7

4

27,5

1,66E−03

1,4

Insulin-like growth factor II

IGF2

−0,02

−0,77

Q96KN2

19

15

128,0

3,08E−03

1,4

Beta-Ala-His dipeptidase

CNDP1

−0,06

−0,76

P04083

17

8

99,3

1,95E−03

1,4

Annexin A1

ANXA1

−0,06

−0,71

Q9Y4B5

4

2

19,1

8,64E−04

1,9

Microtubule cr s-linking factor 1

MTCL1

−0,01

−0,69

H7BZ55

9

6

52,9

8,35E−03

1,4

Putative ciliary rootlet coiled-coil protein 2

CROCC2

−0,05

−0,68

Q562R1

12

4

95,6

2,28E−02

1,2

Beta-actin-like protein 2

ACTBL2

−0,02

−0,66

P00740

13

10

71,8

6,14E−04

1,4

Coagulation factor IX

F9

−0,03

−0,65

Q6UB98

6

2

36,6

4,79E−03

1,5

Ankyrin repeat domain-containing protein 12

ANKRD12

−0,06

−0,65

H3BMM5

3

2

13,7

1,20E−03

1,4

Uncharacterized protein

 

−0,02

−0,65

P02775

9

7

66,0

8,00E−05

1,5

Platelet basic protein

PPBP

−0,04

−0,63

Q14520

24

18

158,5

1,09E−02

1,4

Hyaluronan-binding protein 2

HABP2

-0,04

-0,63

P23508

5

3

27,9

1,09E-02

1,2

Colorectal mutant cancer protein

MCC

-0,03

-0,63

A5A3E0;Q6S8J3;P0CG39;

Q9BYX7;E7EQ34;O14653

52

14

289,7

1,73E-04

1,4

POTE ankyrin domain family member F

POTEF

-0,03

-0,62

Q15166

6

2

62,1

1,24E-02

2,9

Serum paraoxonase/lactonase 3

PON3

-0,05

-0,61

O75882

16

12

98,9

4,92E-02

1,2

Attractin

ATRN

-0,03

-0,60

P35858;Q2M5E4

34

28

275,0

2,03E-02

1,4

Insulin-like growth factor-binding protein complex acid labile subunit

IGFALS

-0,08

-0,60

P43251

11

7

75,6

1,24E-02

1,5

Biotinidase

BTD

-0,03

-0,60

Q9Y6X9

5

3

27,1

6,14E-04

−5,7

MORC family CW-type zinc finger protein 2

MORC2

0,02

0,62

  1. These proteins passed the criteria for OPLS-DA modeling and also had a Mann-Whitney U test p-value of less than 0.05. Accession, peptide count, unique peptides, confidence score, p-value, fold change, protein name, gene name, covariance (p [1]), and correlation (p (corr) [1]) are given in the table