Fig. 5

Pressurotopic model for binomial always-on heterochromatin gene transcription by anisotropic or mesotropic DNA strand loop micro-structural segmentation. In the binomial always-on model of gene transcription by micro-structural segmentation pressurotopy, mesotropy and amorphousity loop form heterochromatin loop tropy strand genes positioned between 11.7 and 60.4⁰ degrees in the z, y-vertical plane perceiving asymmetric viscosity effects of the same align for transcription during increases of P_eff to between 0.245 and 0.648 esebssiwaagoT_Q units within inner nuclear membrane (INM)-associated heterochromatin; whereas, anisotropy and amorphousity loop form heterochromatin loop tropy strand genes positioned between 60.5 and 82.3⁰ in the z, y-vertical plane perceiving lesser grade asymmetric viscosity effects of the same align for transcription during decreases in P_eff to between 0.064 and 0.2445 esebssiwaagoT_Q units within peripheral nucleoplasm heterochromatin in association with un-limiting nuclear pore subunits. Heterochromatin shifts towards the inner nuclear envelope margin following the transcription of EMD (P_eff, 0.234; θ_A = 61.7⁰) during which positive pressuromodulation at the cell membrane regulates mechanotransduction apparatus sensitivity for linear increases in nuclear effective pressure (P_eff) and resultant mesotropic gene transcription; whereas, heterochromatin shifts towards the central peripheral nucleoplasm edge due to negative pressuromodulation at the cell membrane and mitochondrial oxidative challenge-exothermy, during which transcription of inner nuclear envelope peptide-coding genes LMNB1 (P_eff, 0.197; θ_A = 66.2⁰) → LMNA (P_eff, 0.184; θ_A = 67.8⁰) to LMNB2 (P_eff, 0.167; θ_A = 69.8⁰) regulates sensitivity for linear increases (or decreases) in mechanotransduction pressure esebssiwaagoT_Q units. Legend. Cyan oval, complete nuclear pore complex with all subunits; light cyan oval, partial nuclear pore complex with some subunits; dark blue triangle, lamin and lamin-associated proteins; light blue triangle, lamin and lamin-associated proteins; transparent ovals, nucleosome with histone proteins; solid gold rectangle, anisotropic chromatin strand loop segment DNA with transcription ready infra-pressuromodulated genes; bright green rectangle, mesotropic chromatin strand loop segment DNA with transcription ready supra-pressuromodulated genes; solid bracket, nuclear membrane nucleoplasm chromatin; dashed bracket, central peripheral edge nucleoplasm chromatin