Anglemetry of neural axis cell differentiation genes by structural pressurotopy of DNA loop strand segment tropy in reference to tissue macro-compliance

Sarin, Hemant

doi:10.1186/s41231-019-0045-4

Table 4 Heterochromatinization parameters for z, y-plane gene angulation positioning and pressuromodulation mapping of effective cell pressures for neuroaxis gene expression of differentiated neuron cell sub-types in reference to tissue macro-compliance

From: Anglemetry of neural axis cell differentiation genes by structural pressurotopy of DNA loop strand segment tropy in reference to tissue macro-compliance

Gene (no. of locus bases; no. of gene bases or n/a)	Gene locus (strand)	Episode category (final SEB structure)	uppesebssiwaa, dppesebssiwaa (P_eff esebssiwaagoT_Q)	f(x)_sebs	b_sebs/b_sebssiwa^b	Angulation (⁰)	Neural axis overexpression (predicted range)^a
Gene (no. of locus bases; no. of gene bases or n/a)	Gene locus (strand)	Episode category (final SEB structure)	uppesebssiwaa, dppesebssiwaa (P_eff esebssiwaagoT_Q)	f(x)_sebssiwa^c	b_sebs/b_sebssiwa^b	Angulation (⁰)	Neural axis overexpression (predicted range)^a
UNC13A, unc-13 homolog A (87,038; n/a)	19p13.11 (−)	2 M 3	44,222, 101,999 (0.434)	−	n/a	37.6	lmn (a)
UNC13A, unc-13 homolog A (87,038; n/a)	19p13.11 (−)	2 M 3	44,222, 101,999 (0.434)	−	n/a	37.6	lmn (a)
RGS21, regulator of G protein signaling 21 (50,294; n/a)	1q31.2 (+)	2 M 5	62,631, 151,780 (0.413)	1.11284E+05 e^4E-06x	5.03	40.1	̶
RGS21, regulator of G protein signaling 21 (50,294; n/a)	1q31.2 (+)	2 M 5	62,631, 151,780 (0.413)	2.2137E+04 e^3E-06x	5.03	40.1	̶
SOX1, SRY-Box 1 (160,765; 4,108)	13q34 (+)	2 M 7 q term end	24,498, 77,119 (0.318)	1.20477E+05 e^7E-06x	3.01	51.6	pituit, capc, bell (pj)
SOX1, SRY-Box 1 (160,765; 4,108)	13q34 (+)	2 M 7 q term end	24,498, 77,119 (0.318)	3.9963E+04 e^2E-05x	3.01	51.6	pituit, capc, bell (pj)
NGB, neuroglobin (5,830; n/a)	14q24.3 (−)	3 A 5	14,618, 48,000 (0.305)	2.50250E+05 e^2E-05x	3.78	53.2	thal, bral, umn (arc)
NGB, neuroglobin (5,830; n/a)	14q24.3 (−)	3 A 5	14,618, 48,000 (0.305)	6.6186E+04 e^2E-05x	3.78	53.2	thal, bral, umn (arc)
SHANK2, SH3 And Multiple Ankyrin Repeat Domains 2 (784,883; n/a)	11q13.3-q13.4 (−)	6 A 13	27,834, 92,467 (0.301)	6.12243E+05 e^1E-07x	7.42	53.6	umn (asc, dsc)
	11q13.3-q13.4 (−)	6 A 13	27,834, 92,467 (0.301)	8.2498E+04 e^4E-06x	7.42	53.6	umn (asc, dsc)
RGS2, regulator of G protein signaling 2 (3,245; n/a)	1q31.2 (+)	3 M 7	95,617, 321,146 (0.298)	6.84931E+05 e^1E-06x	2.95	54	bgnc
RGS2, regulator of G protein signaling 2 (3,245; n/a)	1q31.2 (+)	3 M 7	95,617, 321,146 (0.298)	2.31902E+05 e^3E-06x	2.95	54	bgnc
RGS16, regulator of G protein signaling 16 (5,791, n/a)	1q23.3 (−)	3 M 5	32,709, 130,446 (0.251)	2.45881E+05 e^3E-06x	1.57	59.7	̶
RGS16, regulator of G protein signaling 16 (5,791, n/a)	1q23.3 (−)	3 M 5	32,709, 130,446 (0.251)	1.56958E+05 e^6E-06x	1.57	59.7	̶
DRD1, Dopamine Receptor D1 (4,170; n/a)	5q35.2 (+)	3 M 8	50,934, 204,294 (0.249)	6.93874E+05 e^2E-06x	4.00	59.9	̶
DRD1, Dopamine Receptor D1 (4,170; n/a)	5q35.2 (+)	3 M 8	50,934, 204,294 (0.249)	1.73469E+05 e^6E-06x	4.00	59.9	̶
SOX14, SRY-Box 14 (2,055; n/a)	3q22.3 (+)	3 A 7	43,588, 198,734 (0.219)	1.209365E+06 e^4.5E-06x	3.62	63.5	̶
SOX14, SRY-Box 14 (2,055; n/a)	3q22.3 (+)	3 A 7	43,588, 198,734 (0.219)	3.34544E+05 e^1E-05x	3.62	63.5	̶
DRD2, Dopamine Receptor D2 (66,097; n/a)	11q23.2 (−)	2 A 5	38,628, 178,043 (0.217)	1.10192E+05 e^4E-07x	1.51	63.8	bgnc
DRD2, Dopamine Receptor D2 (66,097; n/a)	11q23.2 (−)	2 A 5	38,628, 178,043 (0.217)	7.2871E+04 e^4E-06x	1.51	63.8	bgnc
RBFOX3, RNA Binding Fox-1 Homolog 3 (521,757, n/a)	17q25.3 (−)	5 M 13	21,887, 102,648 (0.213)	1.0E+06 e^3E-06x	4.29	64.3	bell (gr); bral, umn (arc)
RBFOX3, RNA Binding Fox-1 Homolog 3 (521,757, n/a)	17q25.3 (−)	5 M 13	21,887, 102,648 (0.213)	2.08197E+05 e^3E-05x	4.29	64.3	bell (gr); bral, umn (arc)
RGS18, regulator of G protein signaling 18 (378,397; 28,716)	1q31.2 (+)	4 M 11	46,829, 227,894 (0.205)	2.0E+06 e^2E-06x	4.19	65.2	̶
	1q31.2 (+)	4 M 11	46,829, 227,894 (0.205)	4.77757E+05 e^2E-05x	4.19	65.2	̶
GRIN1, Glutamate Ionotropic Receptor NMDA Type Subunit 1 (30,373; n/a)	9q34.3 (+)	2 M 5	14,630, 72,035 (0.203)	1.86172E+05 e^2E-06x	1.46	65.5	̶
	9q34.3 (+)	2 M 5	14,630, 72,035 (0.203)	1.27295E+05 e^4E-05x	1.46	65.5	̶
DRD3, Dopamine Receptor D3 (347,501; 71,611)	3q13.31 (−)	4 A 9	16,088, 79,289 (0.203)	6.3965E+04 e^3E-07x	3.81	65.5	capc
DRD3, Dopamine Receptor D3 (347,501; 71,611)	3q13.31 (−)	4 A 9	16,088, 79,289 (0.203)	1.6772E+04 e^5E-07x	3.81	65.5	capc

^aNeuroanatomic location cell-specific ranges of effective cell pressure for gene overexpression: lmn (a), lower motor neuron (afferent), P_eff 0.434 ≥ 0.301; umn (asc, dsc, arc), upper motor neuron (ascending, descending, arcuate association), P_eff ≤ 0.301; pituit, hypothalamic posterior pituitary axis neurons, upper limit P_eff 0.331 ≥ 0.311; thal, peri-ventricular thalamic deep nuclei neurons, upper limit P_eff 0.311 ≥ 0.305; capc, cornu ammonis/Papez circuit (pyramidal neuron, 3-layer cortex), P_eff 0.318–0.203; bell, cerebellar cortex neurons [bell (pj), purkinje cell layer, P_eff 0.301; bell (gr), granule cell layer, P_eff 0.213]; bral, cerebral cortex (pyramidal neuron, 6-layer), P_eff < 0.318 ≥ 0.305–0.213; and bgnc, basal ganglia nuclei substantia nigra circuit (spiny neuron, dopaminergic), P_eff 0.298 - < 0.217 > 0.213. ^cf(x) = b·e^m·x, where b is the downstream anisotropic effect (intercept and slope are absolute values). ^bb_sebs/b_sebssiwa is the linearization quotient. Note: ¹⁾ gene loci sub-episode block structure (SEB) variations include non-contributory anisotropy (NCA), anisotropy converted to mesotropy (ACM), and/or 0.5-factor adjusted stabilizing mesotropy or anisotropy converted to stabilizing isotropy for anisotropy or mesotropy (stIAfM, stIMfA or stIMfM) that result in an initial to final SEB conversion; ²⁾ previously reported episode and sub-episode block structure is applied in all cases as per reference [25], in which gene/gene loci at cusps of the delineated base intervals, SHANK2 (784,883), RBFOX3 (521,757) classify into the adjacent interval; ³⁾ Sub-episode block structures for initial to final SEB converted genes are as follows: NGB, 3 A 7 (−2) stIMfA NCA; SOX1, 2 M 5 (+2) ACM q terminal end; RGS18, 4 M 9 (+2) ACM; RBFOX3, 5 M 11 (+2) ACM; RGS16, 3 M 7 (−2) NCA; DRD1, 3 A 7 (+1) ACM; and UNC13A, 2 M 5 (−2) ACM; and ⁴⁾ b_sebs/b_sebssiwa quotients for DRD1, DRD2 and DRD3 are by reverse x-intercept plotting the uppasebs, uppamsebs, dppasebs and dppmsebs and the corelate uppasebssiwa, uppamsebssiwa, dppasebssiwa and dppmsebssiwa

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