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Fig. 3 | Translational Medicine Communications

Fig. 3

From: Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles

Fig. 3

Stage-gate decision process in drug discovery and development. Go/no-go decision making process along milestones such as those indicated above used in biopharmaceutical industry during drug discovery and development process. As in preclinical and clinical development, go / no-go decision setpoints are defined for each milestone according to the target product profile that must be fulfilled to continue drug discovery and development process. Discovery and development research is also covered by benchmark initiatives which provide average risk/ success rates, timelines, and resources used per milestone. Adapted from [111]

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