Fig. 2

Estimating immune cells infiltration in the synovium using transcriptomics profile of rheumatoid arthritis (RA) patients versus healthy controls (N) and osteoarthritis (OA). We used the ESTIMATE tool to estimate the difference in the infiltration of immune cells in healthy, OA, and RA synovium using their transcriptomic profile. The raw RNAseq data were used for in silico prediction of the immune cells’ infiltration of the synovial tissue using CIBERSORT analytical tool to evaluate changes in the immune population and/or activation status between the groups