Fig. 1

Schematics illustrating the pathophysiologic natural progression of EoE from healthy, to acute eosinophil infiltration during an atopic reaction (redness and red spherical cells indicate inflammation), to incipient fibrosis after prolonged inflammatory conditions (arising strictures due to increased development of underlying fibrosis), to chronic fibrotic constrictions of the esophageal wall (severe strictures due to advanced fibrotic remodeling). a Anatomic representation of distal esophagus and proximal stomach. b Cross-sectional view of esophagus such as that provided by WLE. c Histologic section of relevant cellular linings – epithelium and lamina propria (figure following [1])