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Fig. 3 | Translational Medicine Communications

Fig. 3

From: In vivo optical endomicroscopy: two decades of translational research towards next generation diagnosis of eosinophilic esophagitis

Fig. 3

Milestone 1: Principles of endoscopic OCT. a Fiber-based Michelson interferometer endoscopic OCT setup sketch illustrating the different OCT configurations. Time-domain (TD) OCT (blue) vs. Fourier-domain (FD: spectral-domain (SD) OCT (green) vs. swept source (SS) OCT (yellow)) OCT. b and c illustrate the two fundamental types of endoscopic OCT imaging probes – forward-viewing (b), including a non-specified beam scanning unit (BSU), and side-viewing (c). d Exemplary WLE image of a human esophagus in vivo. e and f depict reprints from a first preclinical in vivo and a first-in-human report, respectively. e shows first circular OCT scans of a rabbit’s esophagus in vivo (figure and caption adapted and reprinted with permission from [44] © The American Association for the Advancement of Science). f shows a linear OCT scan of esophageal tissue of a first healthy subject in vivo, presenting the well-known layered structure (figure and caption adapted and reprinted with permission from [46] © The Optical Society)

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Translational Medicine Communications

ISSN: 2396-832X

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