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Fig. 4 | Translational Medicine Communications

Fig. 4

From: Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model

Fig. 4

Expression of key markers of ECM remodeling and inflammation in joint capsular tissue of ALM-treated and saline control animals, 4 weeks following knee implant surgery. mRNA expression of a Col3a1:Col1a1 ratio, and b Xylt1 tended to be lower in capsular tissue from ALM-treated animals, compared to controls, though these differences were not statistically significant. Compared to controls, c Fgf1, and d Pdgfa expression was significantly lower in joint tissue from ALM-treated animals. Compared to controls, mRNA expression of e NFkB1 and f NOS2 and protein expression of g IL-1β, and h IL-12p70 was lower in the ALM treatment group. Data are expressed as mean ± SD. *P < 0.05, vs. baseline (no surgery, no treatment), #P < 0.05, compared to saline controls; n = 6 per group

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Translational Medicine Communications

ISSN: 2396-832X

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