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Table 5 Genotypes and allele frequencies of ACE rs4646994, ATG rs699 and AGTR1 rs5186 polymorphisms in COVID-19 patients and controls

From: Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

Polymorphisms

Genetic Models

Patients, n (%)

Control, n (%)

Crude analysis

Adjusted analysisa

ACE rs4646994

Codominant

  

OR (95% CI)

p

OR (95% CI)

p

DD

144 (55.8)

70 (28.7)

1.00

–

1.00

–

ID

89 (34.5)

123 (50.4)

0.35 (0.23–0.52)

< 0.001

0.38 (0.24–0.60)

< 0.001

II

25 (9.7)

51 (20.9)

0.23 (0.13–0.41)

< 0.001

0.11 (0.05–0.21)

< 0.001

Dominant

      

DD

144 (55.8)

70 (28.7)

1.00

–

1.00

–

ID + II

114 (44.2)

174 (71.3)

0.31 (0.21–0.46)

< 0.001

0.27 (0.18–0.42)

< 0.001

Recessive

      

DD + ID

233 (90.3)

193 (79.1)

1.00

–

1.00

–

II

25 (9.7)

51 (20.9)

0.40 (0.24–0.67)

< 0.001

0.18 (0.09–0.34)

< 0.001

Overdominant

      

DD + II

169 (65.5)

121 (49.6)

1.00

–

1.00

–

ID

89 (34.5)

123 (50.4)

0.51 (0.36–0.74)

< 0.001

0.71 (0.47–1.06)

0.058

Alleles

      

D

377 (73.6)

263 (53.89)

1.00

–

1.00

–

I

139 (26.94)

225 (46.11)

0.43 (0.33–0.56)

< 0.001

0.32 (0.24–0.43)

< 0.001

ATG rs699

Codominant

      

TT

20 (9.2)

113 (46.1)

1.00

–

  

TC

197 (90.8)

132 (53.9)

8.43 (4.99–14.24)

< 0.001

18.17 (9.88–33.39)

< 0.001

Alleles

      

T

237 (54.61)

358 (73.06)

1.00

–

1.00

–

C

197 (45.39)

132 (26.94)

2. 25 (1.71–2.96)

< 0.001

3.61 (2.58–5.05)

< 0.001

ATGR1 rs5186

Codominant

      

AA

154 (74.4)

185 (75.8)

1.00

–

1.00

–

AC

49 (23.7)

59 (24.2)

0.99 (0.64–1.54)

0.5

0.83 (0.51–1.36)

0.28

CC

4 (1.9)

0

–

–

–

–

Dominant

      

AA

154 (74.4)

185 (75.8)

1.00

–

1.00

–

AC + CC

53 (25.6)

59 (24.2)

1.07 (0.70–1.65)

0.40

0.90 (0.55–1.45)

0.38

Recessive

      

AA + AC

203 (98.1)

244 (100)

1.00

–

1.00

–

CC

4 (1.9)

0

–

–

–

–

Overdominant

      

AA + CC

158 (76.3)

185 (75.8)

1.00

–

1.00

–

AC

49 (23.7)

59 (24.2)

0.97 (0.62–1.50)

0.49

0.82 (0.50–1.33)

0.24

Alleles

      

A

357 (86.81)

429 (87.91)

1.00

–

1.00

–

C

57 (13.19)

59 (12.09)

1.10 (0.74–1.63)

0.34

0.99 (0.64–1.52)

0.52

  1. aAdjusted for age and sex