Polymorphisms | Genetic Models | Patients, n (%) | Control, n (%) | Crude analysis | Adjusted analysisa | ||
---|---|---|---|---|---|---|---|
ACE rs4646994 | Codominant | Â | Â | OR (95% CI) | p | OR (95% CI) | p |
DD | 144 (55.8) | 70 (28.7) | 1.00 | – | 1.00 | – | |
ID | 89 (34.5) | 123 (50.4) | 0.35 (0.23–0.52) | < 0.001 | 0.38 (0.24–0.60) | < 0.001 | |
II | 25 (9.7) | 51 (20.9) | 0.23 (0.13–0.41) | < 0.001 | 0.11 (0.05–0.21) | < 0.001 | |
Dominant | Â | Â | Â | Â | Â | Â | |
DD | 144 (55.8) | 70 (28.7) | 1.00 | – | 1.00 | – | |
ID + II | 114 (44.2) | 174 (71.3) | 0.31 (0.21–0.46) | < 0.001 | 0.27 (0.18–0.42) | < 0.001 | |
Recessive | Â | Â | Â | Â | Â | Â | |
DD + ID | 233 (90.3) | 193 (79.1) | 1.00 | – | 1.00 | – | |
II | 25 (9.7) | 51 (20.9) | 0.40 (0.24–0.67) | < 0.001 | 0.18 (0.09–0.34) | < 0.001 | |
Overdominant | Â | Â | Â | Â | Â | Â | |
DD + II | 169 (65.5) | 121 (49.6) | 1.00 | – | 1.00 | – | |
ID | 89 (34.5) | 123 (50.4) | 0.51 (0.36–0.74) | < 0.001 | 0.71 (0.47–1.06) | 0.058 | |
Alleles | Â | Â | Â | Â | Â | Â | |
D | 377 (73.6) | 263 (53.89) | 1.00 | – | 1.00 | – | |
I | 139 (26.94) | 225 (46.11) | 0.43 (0.33–0.56) | < 0.001 | 0.32 (0.24–0.43) | < 0.001 | |
ATG rs699 | Codominant | Â | Â | Â | Â | Â | Â |
TT | 20 (9.2) | 113 (46.1) | 1.00 | – |  |  | |
TC | 197 (90.8) | 132 (53.9) | 8.43 (4.99–14.24) | < 0.001 | 18.17 (9.88–33.39) | < 0.001 | |
Alleles | Â | Â | Â | Â | Â | Â | |
T | 237 (54.61) | 358 (73.06) | 1.00 | – | 1.00 | – | |
C | 197 (45.39) | 132 (26.94) | 2. 25 (1.71–2.96) | < 0.001 | 3.61 (2.58–5.05) | < 0.001 | |
ATGR1 rs5186 | Codominant | Â | Â | Â | Â | Â | Â |
AA | 154 (74.4) | 185 (75.8) | 1.00 | – | 1.00 | – | |
AC | 49 (23.7) | 59 (24.2) | 0.99 (0.64–1.54) | 0.5 | 0.83 (0.51–1.36) | 0.28 | |
CC | 4 (1.9) | 0 | – | – | – | – | |
Dominant | Â | Â | Â | Â | Â | Â | |
AA | 154 (74.4) | 185 (75.8) | 1.00 | – | 1.00 | – | |
AC + CC | 53 (25.6) | 59 (24.2) | 1.07 (0.70–1.65) | 0.40 | 0.90 (0.55–1.45) | 0.38 | |
Recessive | Â | Â | Â | Â | Â | Â | |
AA + AC | 203 (98.1) | 244 (100) | 1.00 | – | 1.00 | – | |
CC | 4 (1.9) | 0 | – | – | – | – | |
Overdominant | Â | Â | Â | Â | Â | Â | |
AA + CC | 158 (76.3) | 185 (75.8) | 1.00 | – | 1.00 | – | |
AC | 49 (23.7) | 59 (24.2) | 0.97 (0.62–1.50) | 0.49 | 0.82 (0.50–1.33) | 0.24 | |
Alleles | Â | Â | Â | Â | Â | Â | |
A | 357 (86.81) | 429 (87.91) | 1.00 | – | 1.00 | – | |
C | 57 (13.19) | 59 (12.09) | 1.10 (0.74–1.63) | 0.34 | 0.99 (0.64–1.52) | 0.52 |