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Fig. 2 | Translational Medicine Communications

Fig. 2

From: Global conserved RBD fraction of SARS-CoV-2 S-protein with T500S mutation in silico significantly blocks ACE2 and rejects viral spike

Fig. 2

Due to H-bond based close proximity of CUT4 with ACE2 (S Table 1), unmutated CUT4-THR500 did not showed and hydrogen bond with ACE2-TYR41 (a). T500S mutation only replaced the larger structure of THR with SER but mode it convenient to form H-bond with ACE2-TYR41 due to presence of same –OH group (b) and stabilized the ACE2-CUT4 mutant binding. Finally confirms the displacement of nCOV2 spike glycoprotein binding

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Translational Medicine Communications

ISSN: 2396-832X

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