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Fig. 5 | Translational Medicine Communications

Fig. 5

From: AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC

Fig. 5

Canonical pathway analysis shows AMP5A directional regulation of cytokines and chemokines are predicted to inhibit pathways associated with increased inflammation. Log2 fold-changes and p-values of cytokines and chemokines from the 48-plex cytokine array comparing saline-treated versus AMP5A-treated PMA-differentiated THP-1 cells activated with 5 µg/ml CL075 for 24h were uploaded into IPA for canonical pathway analysis. Dark grey = pathway predicted to be activated, z-score > 2, black = pathway predicted to be inhibited, z-score < -2, white = directional regulation unable to be predicted, z = 0

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Translational Medicine Communications

ISSN: 2396-832X

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