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Table 3 Significant changes in IL-12p40 and IL-6 to IL-10 ratios induced by AMP5A. PMA-differentiated THP-1 were exposed to saline or AMP5A and then stimulated with 5 µg/ml CL075 for 24 hours. The release of IL-12p40, IL-6, and IL-10 was then determined using a 48-multi-plex array. The resulting measurements were then used to calculate the ratio of IL-12p40 or IL-6 to IL-10 in these cultures. Data are presented as Mean ratios ± STD (n = 3, p-value = ≤ 0.05)

From: AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC

Biologically relevant cytokine ratios

Mean

Std

N = 1

N = 2

N = 3

IL-12p40/IL-10 for Saline + CL075

10.3

3.5

10.0

6.9

13.9

IL-12p40/IL-10 for AMP5A + CL075

1.3

0.7

1.2

0.7

2.0

IL-6/IL-10 for Saline + CL075

8.0

4.1

8.7

3.6

11.8

IL-6/IL-10 for AMP5A + CL075

0.6

0.2

0.4

0.7

0.7