Table 1 Description of eukaryotic ribonucleases of articles included in the review
From: Promises of eukaryotic ribonucleases for cancer treatment: a systematic review
No | Author, YYYY | RNase Name | RNase Source | RNase Superfamily | Population, Intervention, Comparator and Outcomes (PICOs) | Ref | |||
|---|---|---|---|---|---|---|---|---|---|
Cancer cells / patients | Eukaryotic RNase | Placebo / Other | Apoptosis / Improvement | ||||||
1 | Laccetti et al., 1992 | BS-RNase | Bovine seminal vesicles | Pancreatic-type RNase | Cancer cell lines and mice | BS-RNase | Normal/untreated cells / mice | Growth inhibition, anticancer | [11] |
2 | Laccetti et al., 1994 | BS-RNase | Bovine seminal vesicles | Pancreatic-type RNase | Cancer cell lines & mice | BS-RNase | Normal cells and mice | Antitumor and anti-metastatic | [12] |
3 | Pouckova et al., 1998 | BS RNase | Bull seminal vesicle fluid | Pancreatic-type RNase | Athymic nude mice | BS RNase | Untreated nude mice | Antitumor action | [13] |
4 | Di Liddo et al., 2010 | Bovine milk RNase-4 | Bovine milk protein | RNase-4 | Cancer cell lines | Bovine milk RNase-4 | Untreated cells and RNase-A | Cytotoxicity (growth inhibitory effect) | [14] |
5 | Patutina et al., 2011 | RNase A | Bovine pancreas | RNase A | murine models | RNase A | Saline treated mice | Decreased metastasis | [15] |
6 | Darzynkiewicz et al., 1988 | Pannon (P-30 Protien) | Vertebrate tissue extract | Pancreatic ribonuclease A | Cancer cell lines | Pannon (P-30 Protien) | Untreated cells | Apoptosis | [16] |
7 | Vasandani et al., 1999 | Onconase (Onc®) | Oocytes of Leopard frog (Rana pipiens) | pancreatic ribonuclease A (RNase A) | Apparently healthy mice | Onconase | Unexposed apparently healthy mice | Nephrotoxicity | [17] |
8 | Lee et al., 2000 | Onconase (Onc®) | Amphibian oocytes | Pancreatic ribonuclease A | Cancer cell lines and mice | Onconase (Onc®) | Untreated cells / mice | Antitumor efficacy and lower TIFP | [18] |
9 | Vogelzang et al.,2001 | Ranpirnase (Onc®) | Oocytes of Leopard frog (Ran pipiens) | pancreatic ribonuclease A (RNase A) | Patients With metastasis | Ranpirnase (Onc®) | - | - Survival, - progression time - Toxicities | [19] |
10 | Magnitsky et al., 2006 | Ranpirnase (Onc®) | Eggs & early embryo of Leopard frog R. pipiens | Pancreatic ribonuclease A | Cancer cells and nude mice | Ranpirnase (Onc®) | Untreated cells / mice | Apotosis | [20] |
11 | Lee et al., 2007 | Ranpirnase (Onc®) | Oocytes of Northern Leopard Rana pipiens | Pancreatic ribonuclease A | Cancer cells and nude mice | Ranpirnase (Onc®) | Normal/untreated cells / mice | Antitumor efficacy | [21] |
12 | Mikulski et al., 2002 | Ranpirnase (Onc®) | Eggs and early embryos of Leopard frog R. pipiens | Pancreatic ribonuclease A (RNase A) | Patients with metastasis | Ranpirnase (Onc®) | - | - Survival - Tumor responses - progression Time | [22] |
13 | Smolewski et al., 2014 | Onconase (Onc®) and r-amphinase | Oocytes of Leopard frog (Rana pipiens) | pancreatic ribonuclease A (RNase A) | peripheral blood mononuclear/ Cancer cells | Onconase and r-amphinase | Untreated tumor and healthy lymphocytic cells | Cytotoxicity and apoptosis | [23] |
14 | Ardelt et al., 2007 | Amphinase | Oocytes of Northern Leopard (R. pipiens) | Pancreatic ribonuclease A | Cancer cell lines | Amph Variants | Alkylated Amph-2 | Apoptosis | [24] |
No | Author, YYYY | RNase Name | RNase Source | RNase Superfamily | Population, Intervention, Comparator and Outcomes (PICOs) | Ref | |||
Cancer cells / patients | Eukaryotic RNase | Placebo / Other | Apoptosis / Improvement | ||||||
15 | Liao et al.,2000 | RC-RNase1, 2,3,4,5,6, L1 | Bull frog oocyst (R. catesbeiana) | Pancreatic ribonuclease A | Cancer cell lines | RC-RNase-1, 2,3,4,5,6, L1 | RNase A treated cells | Antitumor efficacy | [25] |
16 | Wang et al., 2015 | Rdchonc RNase | Rana chensinensis changbaishanensis | pancreatic ribonuclease A (RNase A) | Cancer cell lines | Rdchonc RNase | Untreated control cells | Antiproliferative, apoptosis and anti-invasion | [26] |
17 | Griffiths et al., 1997 | hCG 18 K RNase | Human urinary chorionic gonadotropin | RNase A | Cancer cell lines | hCG 18 K RNase | Untreated cells | Antineoplastic Antiproliferative | [27] |
18 | Maeda et al., 2002 | RNase 3 (ECP) | Large granules of mature peripheral blood eosinophils | pancreatic type RNase | Cancer cell lines | RNase 3 (ECP) | Untreated cells | Growth inhibition | [28] |
19 | Castro et al., 2011 | PE5 | Human pancreatic RNase | HP RNase | Cancer cell lines | PE5 | Untreated cells | Apoptosis | [29] |
20 | Zhang et al., 2010 | RNLs30 RNase | Fresh fruiting bodies of the edible mushroom Lyophyllum shimeiji | Mushroom RNase family | Cancer cell lines | Lyophyllum shimeiji RNase | Untreated control cells | Antiproliferative and antitumor | [30] |
21 | Joceph et al., 2020 | Lp16-PSP (Latcripin-16) | Mushroom Lentinula edodes C91-3 | YjgF/YER057c/UK114 | Cancer cell lines | Lp16-PSP (Latcripin-16) | Normal cells | Anticancer and antiproliferative | [31] |
22 | Kumar et al., 2013 | A. niger RNase (ACTBIND) | Aspergillus niger | - | Cancer cell lines | A. niger RNase | Normal cells | Anticancer, anti-invasiveness | [32] |
23 | Skvor et al., 2006 | Wheat leaf RNase (WLN-RNase) | Wheat leaf | Plant ribonuclease | Cancer cells and athymic nude mice | Wheat leaf RNase (WLN-RNase) | RNase A, BS-RNase, Onc treated cells / PBS treated mice | Antiproliferative and antitumor | [33] |
24 | Fang et al., 2012 | MC2 RNase | Dietary bitter gourd (Momordica charantia) | MC2 RNase | Cancer cells and nude mice | MC2 RNase | Untreated cells and nude mice | Antiproliferation, tumor growth | [34] |