Table 5 Tumor volume of eukaryotic ribonucleases treated xeno-grafted experimental animals
From: Promises of eukaryotic ribonucleases for cancer treatment: a systematic review
S/N | Author, YYYY | RNase | Experiment | Tumor volume (Mean, mm3) | Tumor volume | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
In vivo model | Drug Administration | Injection Dose | 1d | 5d | 9d | 11d | 13d | 23d | ||||
1 | Fang et al., 2012 [34] | MC2 RNase | BALB/c Nude mice bearing Hep G2 tumor | Intraperitoneal injection (i.p.) | Control | 10 | 12 | 20 | 30 | 35 | 50 | ↓ |
MC2, 2 mg/kg | 10 | 8 | 7 | 6 | 5 | 1 | ||||||
2 | Lee et al., 2007 [39] | Ranpirnase (Onc®) | Female athymic NCR-nu/nu nude mice bearing human A549 NSCLC xenograft | Intravenous (i.v.) or Intra-peritoneal injection (i.p.) | Control | 250 | 275 | 500 | 750 | 950 | 1750 | ↓ |
ONC, 2.5 mg/kg | 250 | 260 | 350 | 650 | 850 | 1250 | ||||||
ONC, 5 mg/kg | 250 | 250 | 260 | 260 | 550 | 750 | ||||||
ONC, 10 mg/kg | 250 | 250 | 260 | 260 | 250 | 650 | ||||||
3 | Lee et al., 2000 [18] | Ranpirnase (Onc®) | DU145 hu prostate tumor xeno-grafted nude mice | Intraperitoneal injection (i.p.) | Control, Saline | 250 | 400 | 550 | 700 | 950 | 1250 | ↓ |
Onconase, alkylated | 250 | 300 | 400 | 550 | 700 | 1200 | ||||||
Onconase, 5 mg/kg | 250 | 100 | 100 | 200 | 300 | 700 | ||||||
4 | Magnitsky et al., 2006 [20] | Ranpirnase (Onc®) | A549 tumor bearing Female Athymic NCR-nu/nu nude mice | Subcutaneous | Control, saline | 250 | 250 | 350 | 500 | 550 | 750 | ↓ |
Cisplatin, 5 mg/kg | 250 | 250 | 300 | 350 | 400 | 450 | ||||||
Onconase, 10 mg/kg | 250 | 250 | 200 | 200 | 250 | 300 | ||||||
Onconase + Cisplatin | 250 | 200 | 200 | 150 | 200 | 250 | ||||||
5 | Pouckova et al., 1998 [13] | BS-RNase | Human melanoma xenografted mouse | Intratumoral injection (i.t.) | Control | 50 | 70 | 100 | 140 | 300 | 320 | ↓ |
BS-RNase, 12.5 mg/kg | 30 | 20 | 20 | 10 | 5 | 4 | ||||||
BS-RNase | Mice seminoma xenografted mouse | Intratumoral injection (i.t.) | Control | 40 | 50 | 100 | 160 | 180 | 200 | ↓ | ||
BS-RNase, 12.5 mg/kg | 40 | 5 | 0 | 0 | 0 | 0 | ||||||
6 | Skvor et al.,2006 [40] | WLN-RNase | Athymic human xenograft melanoma nu/nu mice | Intraperitoneal injection (i.p.) | Ctrl, PBS,100 μg /mouse | 20 | 40 | 100 | 180 | 250 | 280 | ↓ |
RNase A,100 μg /mouse | 20 | 40 | 100 | 190 | 240 | 280 | ||||||
WLN-RNase,100 μg/mouse | 10 | 15 | 30 | 70 | 100 | 120 | ||||||
BS-RNase,100 μg /mouse | 10 | 10 | 15 | 40 | 50 | 70 | ||||||