A SNP in the 5’ flanking region of the SAA1 gene is associated with serum levels of serum amyloid A and cardiovascular risk factors

Table 3 Associations between the rs11024595 SNP and investigated cardiovascular risk factors

	SibPair study		SOS study
	P	Parameter estimate (95% confidence interval)	P	Parameter estimate (95% confidence interval)
BMI, kg/m²	0.29	0.093 (-0.084, 0.27)	0.88	0.0077 (-0.090, 0.11)
Sagittal diameter, cm	0.052	0.14 (-0.0012, 0.28)	0.72	-0.018 (-0.12, 0.80)
P-glucose, mmol/L	0.76	0.038 (-0.21, 0.29)	0.044	0.10 (0.0029, 0.20)
S-insulin, mIU/L	0.19	-0.10 (-0.25, 0.052)	0.36	0.044 (-0.049, 0.14)
HOMA-IR	0.27	-0.093 (-0.26, 0.076)	0.12	0.075 (-0.021, 0.17)
S-cholesterol, mmol/L	0.35	-0.095 (-0.30, 0.11)	0.29	0.055 (-0.046, 0.16)
S-triglycerides, mmol/L	0.041	-0.22 (-0.43, -0.0097)	0.025	0.12 (0.015, 0.22)
S-HDL cholesterol, mmol/L	0.77	-0.030 (-0.23, 0.17)	0.0045	-0.14 (-0.24, -0.045)
ApoA1, g/L	-	-	0.19	-0.066 (-0.16, 0.032)
ApoB, g/L	-	-	0.17	0.071 (-0.029-0.17)
ApoE, g/L	-	-	0.026	0.083 (0.010–0.16)

P-values and parameter estimates for the associations between the rs11024595 SNP and investigated cardiovascular risk factors in the SibPair study and the SOS study. The analyses were adjusted for age, sex and BMI except for analysis including indices of adiposity where only adjustment for age and sex was performed. Additional adjustment for non-independence among related individuals was applied in the SibPair study. The parameter estimates are used as an indication of the impact that the rs11024595 SNP has on a variable

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