Fig. 1

The different action of ozone on mitochondria. A High doses of ozone activate a huge ROS response, mitophagy and the shift of the Nrf2/NF-κB rate towards NF-κB, finally leading to an inflamed state even with pyroptosis and apoptosis; B Low doses of ozone, slightly activating the NLRP3 via ROS as signaling molecules, increase the rate Nrf2/NF-κB, triggering an anti-oxidant state and inducing mitochondria biogenesis via PGC-1α