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Fig. 2 | Translational Medicine Communications

Fig. 2

From: RLS-0071, a dual-targeting anti-inflammatory peptide - biomarker findings from a first in human clinical trial

Fig. 2

A Immunecomplex-based classical complement activation assay measuring membrane attack complex (sC5b-9) generation i.e. IC-MAC assay using human plasma spiked with RLS-0071. Ovalbumin-antiovalbumin immunecomplexes were utilized to stimulate immune complex formation. B Scatter plot of IC-MAC assay for Cohort 3 (40 mg/kg infused IV over 10 min) over 2 h Individual subject values are shown as solid circles. Placebo (open circle) shows the average value of the 8 SAD placebo subjects. Horizontal line denotes median value at each timepoint. C Scatter plot IC-MAC assay for Cohort 6 (120 mg/kg infused IV over 20 min) over 24 h. Individual subject values are shown as solid circles. Horizontal line denotes median value at each timepoint

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