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Table 1 Demographics – SAD Cohorts

From: RLS-0071, a dual-targeting anti-inflammatory peptide - biomarker findings from a first in human clinical trial

 

Placebo (N = 8)

RLS-0071

Overall (N = 32)

Cohort 1 2 mg/kg (N = 6)

Cohort 2 10 mg/kg (N = 6)

Cohort 3 40 mg/kg (N = 6)

Cohort 6 120 mg/kg (N = 6)

Treatment Overall (N = 24)

Sex

 Female

1 (12.5)

3 (50.0)

2 (33.3)

4 (66.7)

4 (66.7)

13 (54.2)

14 (43.8)

 Male

7 (87.5)

3 (50.0)

4 (66.7)

2 (33.3)

2 (33.3)

11 (45.8)

18 (56.3)

Race

 White

6 (75.0)

6 (100.0)

6 (100.0)

4 (66.7)

5 (83.3)

21 (87.5)

27 (84.4)

 Black or African American

1 (12.5)

0 (0.0)

0 (0.0)

1 (16.7)

1 (16.7)

2 (8.3)

3 (9.4)

 Asian

1 (12.5)

0 (0.0)

0 (0.0)

1 (16.7)

0 (0.0)

1 (4.2)

2 (6.3)

Ethnicity

 Hispanic Or Latino

1 (12.5)

2 (33.3)

2 (33.3)

1 (16.7)

1 (16.7)

6 (25.0)

7 (21.9)

 Not Hispanic or Latino

7 (87.5)

4 (66.7)

4 (66.7)

5 (83.3)

5 (83.3)

18 (75.0)

25 (78.1)

Age (yrs)

 n

8

6

6

6

6

24

32

 Mean

32.6

39.0

46.5

34.7

33.2

38.3

36.9

 SD

12.39

11.52

7.69

13.02

8.91

11.13

11.52

 Median

28.5

33.0

47.0

34.5

34.0

39.0

35.0

 Min, Max

21, 57

30, 57

35, 59

20, 50

21, 44

20, 59

20, 59

Weight (kg)

 n

8

6

6

6

6

24

32

 Mean

73.71

70.20

69.40

70.18

69.55

69.83

70.80

 SD

12.050

12.787

6.690

10.494

14.861

10.834

11.081

 Median

76.35

71.50

69.70

72.15

72.45

70.75

71.80

 Min, Max

54.4, 88.0

50.7, 86.5

58.3, 79.1

56.9, 82.6

51.4, 87.2

50.7, 87.2

50.7, 88.0

Height (cm)

 n

8

6

6

6

6

24

32

 Mean

174.8

163.7

166.8

168.5

169.5

167.1

169.0

 SD

5.09

10.50

6.18

10.71

9.91

9.15

8.90

 Median

176.0

164.0

168.0

169.5

167.0

167.0

170.5

 Min, Max

163, 180

149, 176

157, 174

152, 183

157, 186

149, 186

149, 186

BMI (kg/m2)

 n

8

6

6

6

6

24

32

 Mean

24.08

26.13

24.98

24.73

23.98

24.96

24.74

 SD

3.359

3.502

2.684

3.121

3.126

3.016

3.074

 Median

23.95

26.85

25.00

25.15

25.55

25.40

25.15

 Min, Max

19.9, 28.4

21.1, 29.6

21.2, 29.0

20.5, 28.2

19.2, 26.6

19.2, 29.6

19.2, 29.6

  1. Abbreviations: BMI body mass index, Max maximum, Min minimum, N/n number of subjects, SAD single-ascending dose, SD standard deviation
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