Table 2 Summary of Demographics – MAD Cohorts
Placebo (N = 6) | RLS-0071 | Overall (N = 24) | ||||
|---|---|---|---|---|---|---|
Cohort 4 2 mg/kg (N = 6) | Cohort 5 10 mg/kg (N = 6) | Cohort 7 40 mg/kg (N = 6) | Treatment Overall (N = 18) | |||
Sex | ||||||
Female | 3 (50.0) | 2 (33.3) | 5 (83.3) | 2 (33.3) | 9 (50.0) | 12 (50.0) |
Male | 3 (50.0) | 4 (66.7) | 1 (16.7) | 4 (66.7) | 9 (50.0) | 12 (50.0) |
Race | ||||||
White | 6 (100.0) | 5 (83.3) | 6 (100.0) | 5 (83.3) | 16 (88.9) | 22 (91.7) |
Black Or African American | 0 (0.0) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 1 (5.6) | 1 (4.2) |
Multiple | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (16.7) | 1 (5.6) | 1 (4.2) |
Ethnicity | ||||||
Hispanic Or Latino | 2 (33.3) | 3 (50.0) | 2 (33.3) | 1 (16.7) | 6 (33.3) | 8 (33.3) |
Not Hispanic Or Latino | 4 (66.7) | 3 (50.0) | 4 (66.7) | 5 (83.3) | 12 (66.7) | 16 (66.7) |
Age (yrs) | ||||||
n | 6 | 6 | 6 | 6 | 18 | 24 |
Mean | 37.2 | 45.8 | 36.8 | 40.7 | 41.1 | 40.1 |
SD | 13.70 | 8.61 | 13.17 | 16.19 | 12.82 | 12.86 |
Median | 41.0 | 42.5 | 35.5 | 43.0 | 39.5 | 39.5 |
Min, Max | 19, 51 | 38, 57 | 21, 56 | 19, 58 | 19, 58 | 19, 58 |
Weight (kg) | ||||||
n | 6 | 6 | 6 | 6 | 18 | 24 |
Mean | 69.45 | 71.42 | 64.12 | 73.02 | 69.52 | 69.50 |
SD | 13.077 | 14.507 | 5.325 | 12.735 | 11.568 | 11.666 |
Median | 72.05 | 69.20 | 64.80 | 68.50 | 67.20 | 68.05 |
Min, Max | 46.7, 85.0 | 52.5, 89.0 | 56.2, 71.9 | 56.6, 90.6 | 52.5, 90.6 | 46.7, 90.6 |
Height (cm) | ||||||
n | 6 | 6 | 6 | 6 | 18 | 24 |
Mean | 169.3 | 168.3 | 165.2 | 174.2 | 169.2 | 169.3 |
SD | 10.73 | 12.94 | 3.31 | 12.21 | 10.54 | 10.35 |
Median | 171.5 | 174.0 | 164.0 | 176.0 | 169.0 | 169.0 |
Min, Max | 156, 182 | 151, 181 | 162, 171 | 158, 190 | 151, 190 | 151, 190 |
BMI (kg/m2) | ||||||
n | 6 | 6 | 6 | 6 | 18 | 24 |
Mean | 24.05 | 25.05 | 23.55 | 24.02 | 24.21 | 24.17 |
SD | 2.837 | 3.100 | 2.346 | 3.140 | 2.786 | 2.737 |
Median | 24.35 | 24.75 | 23.45 | 23.25 | 23.40 | 23.85 |
Min, Max | 19.2, 27.4 | 21.4, 29.1 | 20.9, 27.1 | 20.3, 29.2 | 20.3, 29.2 | 19.2, 29.2 |