Table 3 Change in plasma total C1q value from pre-dose to 24 h post-dose in healthy volunteer subjects by cohort (single dose, SAD)
Cohort | Number of subjects (N) | C1q (mcg/ml) median change (± SD) | P-value |
|---|---|---|---|
placebo | 8 | -2 (± 12) | NS |
2 mg/kg | 6 | -2 (± 7) | NS |
10 mg/kg | 6 | 0 (± 8) | NS |
40 mg/kg | 6 | + 5 (± 11) | NS |
120 mg/kg | 6 | + 18 (± 7) | 0.004 |