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Table 2 Correlation coefficients between HIF-1α, VEGF-A and HK-I expression and clinicopathological parameters in breast carcinoma

From: Expression of HIF-1α and markers of angiogenesis and metabolic adaptation in molecular subtypes of breast cancer

 

Patient characteristics

HIF-1α

p-value

VEGFA

p-value

HK1

p-value

Low

High

Low

High

Low

High

Age

 ≤ 50

11

20

0.343

8

23

0.608

13

18

0.295

 > 50

12

13

5

20

14

11

 

Histological Subtype

Ductal

16

24

0.276

13

27

0.559

17

23

0.954

Lobular

2

2

1

3

2

2

Others

2

10

2

10

5

7

Family History

Yes

1

5

0.344

2

4

0.534

3

3

0.852

No

18

32

11

39

23

27

Lymph Node

Positive

10

23

0.311

9

24

0.921

15

18

0.415

Negative

10

13

6

17

13

10

Grade

I

2

5

0.834

2

5

0.159

5

2

0.296

II

11

17

11

17

12

16

III

7

14

3

18

8

13

Subtypes ER, PR,Her2

 +  +  + 

6

2

0.097

3

5

0.259

5

3

0.036

 +  + -

12

13

11

14

16

9

 

3

9

2

10

2

10

-  -  -

3

8

2

9

4

7

Menopausal

No

10

14

0.528

8

16

0.266

10

14

0.393

Yes

10

20

6

24

16

14

Necrosis

Absent

12

18

0.861

7

23

0.351

18

12

0.029

Present

11

15

9

17

8

18

Stage

I

3

4

0.631

2

5

0.933

5

2

0.406

II

9

21

8

22

13

17

III

8

11

6

13

9

10