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Table 1 Top 10 ranked GO and KEGG terms for DEGs for a) human or b) mouse data sets

From: Comparison of gene expression between human and mouse iPSC-derived cardiomyocytes for stem cell therapies of cardiovascular defects via bioinformatic analysis

Category

GO ID

Description

Gene Count

P-value

a. Human top 10 ranked GO and KEGG terms

 GO:MF

GO:0005201

Extracellular matrix structural constituent

31

2.934 × 10−16

 GO:MF

GO:0005198

Structural molecule activity

56

5.755 × 10−13

 GO:MF

GO:0005515

Protein binding

405

3.072 × 10−10

 GO:MF

GO:0019838

Growth factor binding

22

6.965 × 10−10

 GO:MF

GO:0005102

Signalling Receptor binding

85

6.875 × 10− 9

 GO:MF

GO:0008307

Structural constituent of muscle

12

1.147 × 10−7

 GO:MF

GO:0048407

Platelet-derived growth factor binding

7

6.545 × 10−7

 GO:MF

GO:0003779

Actin binding

33

4.224 × 10−6

 GO:MF

GO:0030020

Extracellular matrix structural constituent conferring tensile strength

10

1.576 × 10−5

 GO:MF

GO:0005539

Glycosaminoglycan binding

22

2.948 × 10−5

 GO:BP

GO:0072359

Circulatory system development

125

4.102 × 10−42

 GO:BP

GO:0009888

Tissue development

164

3.639 × 10−40

 GO:BP

GO:0009653

Anatomical structure morphogenesis

190

1.027 × 10− 39

 GO:BP

GO:0007507

Heart development

87

1.102 × 10− 39

 GO:BP

GO:0048856

Anatomical structure development

286

3.192 × 10− 36

 GO:BP

GO:0048513

Animal organ development

213

4.501 × 10− 35

 GO:BP

GO:0007275

Multicellular organism development

269

3.918 × 10−34

 GO:BP

GO:0032502

Developmental process

295

1.495 × 10− 33

 GO:BP

GO:0048731

System development

251

5.654 × 10−33

 GO:BP

GO:0032501

Multicellular organismal process

325

1.979 × 10−32

 GO:CC

GO:0031012

Extracellular matrix

65

4.532 × 10− 24

 GO:CC

GO:0062023

Collagen-containing extracellular matrix

52

4.427 × 10− 20

 GO:CC

GO:0043292

Contractile fiber

40

7.417 × 10− 20

 GO:CC

GO:0030016

Myofibril

36

7.681 × 10−17

 GO:CC

GO:0030017

Sarcomere

34

1.992 × 10−16

 GO:CC

GO:0099081

Supramolecular polymer

69

6.482 × 10−13

 GO:CC

GO:0099512

Supramolecular fiber

68

1.488 × 10−12

 GO:CC

GO:0005788

Endoplasmic reticulum lumen

35

5.127 × 10−12

 GO:CC

GO:0031674

I band

23

1.046 × 10−10

 GO:CC

GO:0099080

Supramolecular complex

75

7.206 × 10−10

 KEGG

KEGG:04512

ECM-receptor interaction

15

2.194 × 10−6

 KEGG

KEGG:04510

Focal Adhesion

20

9.739 × 10−5

 KEGG

KEGG:04350

TGF-beta signaling pathway

13

2.084 × 10−4

 KEGG

KEGG:05414

Dilated cardiomyopathy

13

2.664 × 10−4

 KEGG

KEGG:04550

Signaling pathways regulating pluripotency of stem cells

16

2.869 × 10−4

 KEGG

KEGG:04260

Cardiac muscle contraction

12

5.994 × 10−4

 KEGG

KEGG:04974

Protein digestion and absorption

13

6.676 × 10−4

 KEGG

KEGG:05410

Hypertrophic cardiomyopathy

12

8.583 × 10−4

 KEGG

KEGG:04151

PI3K-Akt signaling pathway

25

2.335 × 10−3

 KEGG

KEGG:04261

Adrenergic signaling in cardiomyocytes

13

3.488 × 10−2

b. Mouse top 10 ranked GO and KEGG terms.

 GO:MF

GO:0004308

Exo-alpha-sialidase activity

4

1.652 × 10−3

 GO:MF

GO:0016997

Alpha-sialidase activity

4

1.652 × 10−3

 GO:MF

GO:0052794

Exo-alpha-(2- > 3)-sialidase activity

4

1.652 × 10−3

 GO:MF

GO:0052795

Exo-alpha-(2- > 6)-sialidase activity

4

1.652 × 10−3

 GO:MF

GO:0052796

Exo-alpha-(2- > 8)-sialidase activity

4

1.652 × 10−3

 GO:MF

GO:0008138

Protein tyrosine/serine/threonine phosphatase activity

10

5.683 × 10−3

 GO:BP

GO:0006689

Ganglioside catabolic process

5

4.131 × 10−3

 GO:BP

GO:0009313

Oligosaccharide catabolic process

5

2.322 × 10−2

 GO:BP

GO:0050877

Nervous system process

128

3.665 × 10−2

 GO:CC

GO:0005882

Intermediate filament

26

1.448 × 10−4

 GO:CC

GO:0045111

Intermediate filament cytoskeleton

26

3.344 × 10−3

 KEGG

GO:04915

Estrogen signaling pathway

19

1.095 × 10−3