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Table 5 Pathway enrichment analysis to show the significantly enriched GO and KEGG terms for each subcluster from a) human or b) mouse data sets

From: Comparison of gene expression between human and mouse iPSC-derived cardiomyocytes for stem cell therapies of cardiovascular defects via bioinformatic analysis

Category

GO ID

Description

Gene Count

P-value

a. Pathway enrichment analysis to show the top 3 GO and KEGG terms of Subcluster Ha

 GO:MF

GO:0005201

Extracellular matrix structural constituent

15

1.032 × 10−18

 GO:MF

GO:0005198

Structural molecule activity

21

1.084 × 10−17

 GO:MF

GO:0030020

Extracellular matrix structural constituent conferring tensile strength

8

6.423 × 10−12

 GO:BP

GO:0006936

Muscle contraction

19

3.864 × 10−19

 GO:BP

GO:0003012

Muscle system process

20

1.377x × 10−18

 GO:BP

GO:0070252

Actin-mediated cell contraction

13

5.983 × 10−18

 GO:CC

GO:0099081

Supramolecular polymer

25

2.044 × 10−20

 GO:CC

GO:0099512

Supramolecular fiber

24

5.143 × 10−19

 GO:CC

GO:0099080

Supramolecular complex

25

1.732 × 10−17

 KEGG

KEGG:04260

Cardiac muscle contraction

9

1.136 × 10−9

 KEGG

KEGG:05410

Hypertrophic cardiomyopathy

9

1.554 × 10−9

 KEGG

KEGG:05414

Dilated cardiomyopathy

9

2.554 × 10−9

b. Pathway enrichment analysis to show the top 3 GO and KEGG terms of Subcluster Hb

 GO:MF

GO:0008307

Structural constituent of muscle

4

1.214 × 10−4

 GO:MF

GO:0005102

Signaling receptor binding

11

2.258 × 10−3

 GO:MF

GO:0019838

Growth factor binding

4

1.264 × 10−3

 GO:BP

GO:0072359

Circulatory system development

14

2.763 × 10−7

 GO:BP

GO:0032502

Developmental process

24

1.135 × 10−5

 GO:BP

GO:0035019

Somatic stem cell population maintenance

5

1.171 × 10−4

 GO:CC

GO:0031093

Platelet alpha granule lumen

4

4.123 × 10−4

 GO:CC

GO:0031091

Platelet alpha granule

4

1.430 × 10−3

 GO:CC

GO:0030017

Sarcomere

5

1.844 × 10−3

 KEGG

KEGG:04933

AGE-RAGE signaling pathway in diabetic complications

4

4.815 × 10−3

 KEGG

KEGG:04510

Focal adhesion

5

5.074 × 10−3

c. Pathway enrichment analysis to show the top 3 GO and KEGG terms of Subcluster Hc

 GO:BP

GO:0016567

Protein ubiquitination

5

4.006 × 10−2

 GO:CC

GO:0030017

Sarcomere

5

3.883 × 10−6

 GO:CC

GO:0030016

Myofibril

5

6.403 × 10−6

 GO:CC

GO:0043292

Contractile fiber

5

8.076 × 10− 6

d. Pathway enrichment analysis to show the top 3 GO and KEGG terms of Subcluster Ma

 GO:MF

GO:0004930

G protein-coupled receptor activity Transmembrane signalling receptor activity

10

2.363 × 10−6

 GO:MF

GO:0004888

Transmembrane signalling receptor activity

10

1.200 × 10−5

 GO:MF

GO:0038023

Signaling receptor activity

10

2.208 × 10− 5

 GO:BP

GO:0007186

G protein-coupled receptor signalling pathway

13

5.287 × 10−10

 GO:BP

GO:0006874

Cellular calcium ion homeostasis

6

2.908 × 10−4

 GO:BP

GO:0055082

Cellular chemical homeostasis

7

3.336 × 10− 4

 GO:CC

GO:0043679

Axon terminus

3

1.745 × 10−2

 GO:CC

GO:0044306

Neuron projection terminus

3

2.350 × 10−2

 KEGG

KEGG:04080

Neuroactive ligand-receptor interaction

6

3.988 × 10−4

 KEGG

KEGG:04742

Taste transduction

3

1.856 × 10−2

e. Pathway enrichment analysis to show the top 3 GO and KEGG terms of Subcluster Mb

 GO:MF

GO:0003723

RNA binding

9

9.759 × 10−8

 GO:MF

GO:0003676

Nucleic acid binding

10

4.231 × 10−5

 GO:MF

GO:0043021

Ribonucleoprotein complex binding

4

1.366 × 10−4

 GO:BP

GO:0006396

RNA processing

9

2.465 × 10− 8

 GO:BP

GO:0008380

RNA splicing

7

3.751 × 10−7

 GO:BP

GO:0006397

mRNA processing

7

1.214 × 10−6

 GO:CC

GO:0005687

U4 snRNP

3

2.365 × 10−6

 GO:CC

GO:0097525

Spliceosomal snRNP complex

4

2.365 × 10−6

 GO:CC

GO:0030532

Small nuclear ribonucleoprotein complex

4

4.758 × 10−6

 KEGG

KEGG: 03040

Spliceosome

4

3.249 × 10−5

f. Pathway enrichment analysis to show the top 3 GO and KEGG terms of Subcluster Mc

 GO:MF

GO:0004386

Helicase activity

6

1.539 × 10−3

 GO:MF

GO:0017111

Nucleoside-triphosphatase activity

11

3.713 × 10−3

 GO:MF

GO:0016462

Pyrophosphatase activity

11

6.465 × 10−3

 GO:BP

GO:0006281

DNA repair

9

5.244 × 10−3

 GO:BP

GO:0022402

Cell cycle process

13

5.321 × 10−3

 GO:BP

GO:0000280

Nuclear division

8

1.472 × 10−2

 GO:CC

GO:0000776

Kinetochore

7

1.582 × 10−5

 GO:CC

GO:0005694

Chromosome

14

5.991 × 10−5

 GO:CC

GO:0098687

Chromosomal region

8

9.539 × 10−5

 KEGG

KEGG:03440

Homologous recombination

4

7.741 × 10−4

 KEGG

KEGG:04962

Vasopressin-regulated water reabsorption

3

3.362 × 10−2