Region | Country | Sample size | Reference | Gene content or allele content study | Findings |
---|---|---|---|---|---|
North Africa | Tunisia | N=267 | [35] | Gene content | KIR2DS4 and KIR2DL3 were the most common genes |
Egypt | N=150 | [36] | Gene content | KIR2DL1 was present in all donors (100%) and pseudogene KIR2DP1 was observed in close to 93.8% of donors | |
East Africa | Tanzania | N=253 | [37] | Gene content | The frequencies of KIR3DS1 ranged between 5.3% and 10.3 %. |
N=83 | [35] | Gene and allele content | Three KIR3DL3, two KIR3DL1, and two KIR3DL2 alleles were common across the populations. Two common telB haplotypes are present in the three east African populations: Hadza (11.5% frequency), Iraqw and Datooga The frequencies of the cenA/B and tel A/B ratio of haplotypes in the population from Tanzania ranged between 1.4-2.3 and 2.3 -16.0 respectively., | ||
Uganda | N=492 | [32] | Gene content | High frequencies of KIR2DL2, KIR2DL5, and KIR2DS5 and lower frequencies of KIR2DL3 and KIR2DS3 | |
N=300 | [38] | Gene content | High prevalence of KIR2DL1, KIR3DL1 and KIR2DS4 | ||
West Africa | Ghana | N=235 | [33] | Gene and allele content | 208 allele-level haplotypes from 19 gene content KIR haplotypes were recognized among the Ga-Adangbe population |
Mali | N=58 | [35] | Gene and allele content | Three KIR3DL3, two KIR3DL1, and two KIR3DL2 alleles were common across the populations. KIR3DL3*00901–2DL3*001–2DL1*00302 was the among the most frequent Centromeric haplotype among the Datooga and the Fulani | |
Cote d’Ivoire | N=66 | [34] | Gene content | Exposed Sero Negative Female sex workers (ESNN FSWs showed significantly higher frequencies of inhibitory KIR2DL2 and KIR2DL5 than Seropositive Female sex workers. | |
Burkina Faso | N=279 | [39] | Gene content | High frequency of KIR2DL2, KIR2DS3, and KIR2DS4 genes in HIV -1patients than in the control group | |
Cameroon | N=80 | [17] | Gene content | KIR2DL2, KIR2DL3, KIR3DL1, and KIR2DS2 and KIR2DS4 were present in >70.0% of the study population | |
The Gambia | N=535 | [40] | Gene content | High frequencies of KIR2DL1 and KIR2DL4, low frequencies of KIR2DS1 and KIR2DS5 | |
Southern Africa | South Africa | N=309 | [41] | Gene content | Low frequencies of KIR2DL2/KIR2DL3 and high frequencies of KIR2DL4 and KIR2DL1 across the population studied. |
N=364 | [42] | Gene content | Different frequencies of KIR genes in the black Africans, Caucasians, Indians and mixed ancestry ethnic groups. Indians had high frequencies of KIR2DL2, KIR2DL5, KIR2DS1, KIR2DS2, KIR2DS3 and KIR3DS1, the lowest frequencies of KIR2DL3, KIR2DS4 and KIR3DL1; and a KIR2DL4-negative individual | ||
Zimbabwe | N=183 | [43] | Gene content | KIR2DL3 and KIR3DS1 genes were associated with high plasma Immunoglobulin protein (IP-10 levels.) |