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Table 2 Table showing the different KIR gene content and allele level studies from Africa

From: Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations

Region

Country

Sample size

Reference

Gene content or allele content study

Findings

North Africa

Tunisia

N=267

[35]

Gene content

KIR2DS4 and KIR2DL3 were the most common genes

Egypt

N=150

[36]

Gene content

KIR2DL1 was present in all donors (100%) and pseudogene KIR2DP1 was observed in close to 93.8% of donors

East Africa

Tanzania

N=253

[37]

Gene content

The frequencies of KIR3DS1 ranged between 5.3% and 10.3 %.

 

N=83

[35]

Gene and allele content

Three KIR3DL3, two KIR3DL1, and two KIR3DL2 alleles were common across the populations. Two common telB haplotypes are present in the three east African populations: Hadza (11.5% frequency), Iraqw and Datooga 

The frequencies of the cenA/B and tel A/B ratio of haplotypes in the population from Tanzania ranged between 1.4-2.3 and 2.3 -16.0 respectively.,

Uganda

N=492

[32]

Gene content

 High frequencies of KIR2DL2, KIR2DL5, and KIR2DS5 and lower frequencies of KIR2DL3 and KIR2DS3

 

N=300

[38]

Gene content

High prevalence of KIR2DL1, KIR3DL1 and KIR2DS4

West Africa

Ghana

N=235

[33]

Gene and allele content

208 allele-level haplotypes from 19 gene content KIR haplotypes were recognized among the Ga-Adangbe population

Mali

N=58

[35]

Gene and allele content

Three KIR3DL3, two KIR3DL1, and two KIR3DL2 alleles were common across the populations. KIR3DL3*00901–2DL3*001–2DL1*00302 was the among the most frequent Centromeric haplotype among the Datooga and the Fulani

Cote d’Ivoire

N=66

[34]

Gene content

Exposed Sero Negative Female sex workers (ESNN FSWs showed significantly higher frequencies of inhibitory KIR2DL2 and KIR2DL5 than Seropositive Female sex workers.

Burkina Faso

N=279

[39]

Gene content

High frequency of KIR2DL2, KIR2DS3, and KIR2DS4 genes in HIV -1patients than in the control group

Cameroon

N=80

[17]

Gene content

KIR2DL2, KIR2DL3, KIR3DL1, and KIR2DS2 and KIR2DS4 were present in >70.0% of the study population

The Gambia

N=535

[40]

Gene content

High frequencies of KIR2DL1 and KIR2DL4, low frequencies of KIR2DS1 and KIR2DS5

Southern Africa

South Africa

N=309

[41]

Gene content

Low frequencies of KIR2DL2/KIR2DL3 and high frequencies of KIR2DL4 and KIR2DL1 across the population studied.

 

N=364

[42]

Gene content

Different frequencies of KIR genes in the black Africans, Caucasians, Indians and mixed ancestry ethnic groups. Indians had high frequencies of KIR2DL2, KIR2DL5, KIR2DS1, KIR2DS2, KIR2DS3 and KIR3DS1, the lowest frequencies of KIR2DL3, KIR2DS4 and KIR3DL1; and a KIR2DL4-negative individual

Zimbabwe

N=183

[43]

Gene content

KIR2DL3 and KIR3DS1 genes were associated with high plasma Immunoglobulin protein (IP-10 levels.)