Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations

Table 3 KIR diversity and associations with HIV disease continuum

KIR genes	Populations	HIV stage	Findings	References
KIR2DL5 and KIR2DS1	Cameroonians n = 80 (HIV-exposed infected (HEI) n = 14, HIV-exposed/uninfected (HEU) n = 39, and HIV-unexposed/uninfected (HUU) n = 27)	Infection acquisition	Reduced HIV infection acquisition	[17]
KIR3DS1/ KIR3DL1	Tanzanians, (HIV infected (n = 74) and HIV uninfected (n = 174))	Infection acquisition	Increased HIV infection acquisition	[47]
	European ancestry individuals from Western Australia (n = 365)	Progression to AIDS	Slow progression to AIDS	[48]
	Burkinabes n = 279 (145 HIV-1 infected patients and 134 seronegative individuals (HIV-1 negative)	Infection acquisition	Reduced HIV infection acquisition	[37]
	HIV infected Chinese Han (n = 132)	Progression	Slow progression to AIDS	[19, 34]
KIR2DL5	Polish (n = HIV-1-positive, n = 459, HIV-1 uninfected n = 118) and in uninfected, healthy blood donors, n = 98)	Infection acquisition	Increased HIV infection acquisition	[49]
KIR2DL2	European ancestry individuals from Canada (n = 80 HIV exposed uninfected, 304 HIV infected)	Infection acquisition	Reduced HIV infection acquisition	[50]
KIR2DS2	European ancestry individuals from Western Australia (n = 365)	Progression to AIDS	Faster progression to AIDS	[48]

ISSN: 2396-832X