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Fig. 7 | Translational Medicine Communications

Fig. 7

From: Membrane cholesterol depletion reduces breast tumor cell migration by a mechanism that involves non-canonical Wnt signaling and IL-10 secretion

Fig. 7

Cholesterol depletion does not activate the canonical Wnt/beta-catenin pathway. Lef-1-responsive transcription was accessed by quantifying luciferase activity after treating Lef1-TCF-luciferase reporter stably expressing MDA-MB 231 cells with 2 mM MbCD, Bio or Wnt3a for 24 h. Note the significant Lef-1-responsive transcription of cells treated with Wnt3a and Bio, but not with MbCD, which luciferase activity values were similar to untreated cells (control). Each bar represents the mean and standard error of 3 independent experiments. ***p < 0.001; ANOVA versus control group

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Translational Medicine Communications

ISSN: 2396-832X

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