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Featured article: Safety and efficacy of autologous non-hematopoietic enriched stem cell nebulization in COVID-19 patients

Although clinical aspects of COVID-19 patients have been widely reported and their management has increased tremendously, safe and effective medications are still lacking. Different types of stem cells have been considered 'candidates' in several therapies. Adult stem cells play a key role in maintaining tissue homeostasis, and are most likely present at high concentrations in the bloodstream of COVID-19 patients in response to exuberant inflammatory processes.

The challenege in adult stem cell therapy is the lack of well-established procedures for stem cell characterization without altering their phenotypes and functions. To over these challenges, Ventura-Carmenate and colleagues developed a patented method for isolating an autologous peripheral blood non-hematopoietic enriched stem cell cocktail (PB-NHESC-C) to be administered by the nebulization route. 

In this study, Ventura-Carmenate and colleagues assess the safety and efficacy of PB-NHESC-C stem cell cocktail nebulization as an add-on therapy to standard care for SARS-CoV-2-infected patients.


  1. Authors: Jean-Sébastien Paquette, Hervé Tchala Vignon Zomahoun, Ella Diendere, Gardy Lavertu, Nathalie Rheault, Alfred Kodjo Toi, Mathilde Leblond, Étienne Audet-Walsh, Marie-Claude Beaulieu, Ali Ben Charif, Virginie Blanchette, Jean-Pierre Després, André Gaudreau, Caroline Rhéaume, Marie-Claude Tremblay and France Légaré

  2. Authors: Débora C. R. F. Porchera, Diana F. V. B. Leal, Ana C. O. Braga, Pablo D. C. Pinto, Mayara N. Santana da Silva, Lucas C. Bezerra Santos, Cintia H. Braga da Silva, Giovana E. da Costa, Maria Clara da C. Barros, Aidalucy do S. C. de Athayde, Amanda de N Cohen-Paes, Cleonardo A. da Silva, Paulo P. de Assumpção, Ândrea K. C. Ribeiro-dos-Santos, Sidney E. B. dos Santos, Marianne R. Fernandes…

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Editor-in-Chief: Francesco Marincola, Kite Pharma, USA

Dr. Marincola is Global Head of Research at Kite Pharma, Santa Monica, California. He was previously President and Chief Scientific Officer at Refuge Biotechnologies, Menlo Park, California, Distinguished Research Fellow at AbbVie Corporation; Chief Research Officer at Sidra Research, Qatar; and Tenured Investigator at the National Institutes of Health, Maryland. Dr. Marincola founded in 2003 the Journal of Translational Medicine and is the Editor-in-Chief. He is also Editor-in-Chief of Translational Medicine Communications. He is past-president of the Society for the Immunotherapy of Cancer (SITC) and the International Society for Translational Medicine. He edited several books including the SITC-affiliated Cancer Immunotherapy Principles and Practice Textbook. Dr. Marincola is also an award winning fiction author of The Wise Men of Pizzo and Cat Behind the Window.

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