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  1. Research

    Glyceraldehyde-3-phosphate dehydrogenase is overexpressed in colorectal cancer onset

    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential regulator of glycolysis used as a housekeeping marker for gene/protein normalisation. Given the pivotal role of GAPDH in tumour metabolism, our ...

    Míriam Tarrado-Castellarnau, Santiago Diaz-Moralli, Ibrahim H. Polat, Rebeca Sanz-Pamplona, Cristina Alenda, Víctor Moreno, Antoni Castells and Marta Cascante

    Translational Medicine Communications 2017 2:6

    Published on: 9 June 2017

  2. Methodology

    Analytical validation of an mRNA-based urine test to predict the presence of high-grade prostate cancer

    The challenge for prostate cancer (PCa) diagnosis is to improve the ability to distinguish indolent from aggressive PCa. Increased urinary levels of Distal-less Homeobox 1 (DLX1) and Homeobox C6 (HOXC6) mRNA have...

    Daphne Hessels, Hans de Jong, Sander A. Jannink, Michael Carter, Manuel Krispin, Wim Van Criekinge, Leander Van Neste and Jack A. Schalken

    Translational Medicine Communications 2017 2:5

    Published on: 11 May 2017

  3. Research

    Residual risk of transfusion-transmitted malaria infection in a malaria endemic sub-Saharan African setting

    In Cameroon, as in many malaria endemic countries in Africa, blood donors are not routinely screened for Plasmodium infection that potentially could lead to severe malaria in some recipients. This study aimed at ...

    Cécile Okalla Ebongue, Eveline Ngouadjeu Dongho, Gaétan Texier, Jean-Pierre Nda Mefo’o, Gerald Sume Etapelong, Lawrence Ayong and Carole Else Eboumbou Moukoko

    Translational Medicine Communications 2017 2:4

    Published on: 11 March 2017

  4. Research

    Total lymphocyte count in cancer patients with lymphopenia treated with intravenous vitamin C: Results of an observational study

    Lymphopenia commonly occurs in cancer patients and predicts poor prognosis. It is caused by radio- and chemotherapy, with malnutrition and treatment-related oxidative stress playing key roles in its pathogenes...

    Dolores Margarita Rodríguez, Mery Elizabeth Guerrero, Bárbara Marisol Maldonado, Claudia Vollbracht and Sandra Aracely Herrera

    Translational Medicine Communications 2017 2:3

    Published on: 10 March 2017

  5. Research

    Job performance in chronic hepatitis C virus patients treated with pegylated interferon-α2b plus ribavirin: an observational study

    The employment status of workers with chronic hepatitis C has important implications for society and labor market, for organizations and for the individuals and their economic, social and psychological status....

    Giulia Malaguarnera, Gaetano Bertino, Carmela Greco, Caterina Gagliano, Massimo Motta, Giuseppe Chisari, Venerando Rapisarda, Giuseppe Nunnari, Michele Vecchio, Filippo Drago and Michele Malaguarnera

    Translational Medicine Communications 2017 2:2

    Published on: 21 February 2017

  6. Research

    Cryoinjury-induced acute myocardial infarction model and ameroid constrictor-induced ischemic heart disease model in adult micro-mini pigs for preclinical studies

    Coronary artery diseases (CAD) are the most commonly occurring disorders in the developed countries. Development of new therapeutics and their success in clinical studies require confirmation of therapeutic ef...

    Akinori Hirano, Jun Fujita, Hideaki Kanazawa, Shinji Kawaguchi, Noriko Handa, Yoshitake Yamada, Shigeo Okuda, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Shugo Tohyama, Tomohisa Seki, Ryota Tabei, Kazuaki Nakajima, Yoshikazu Kishino, Marina Okada…

    Translational Medicine Communications 2017 2:1

    Published on: 8 February 2017

  7. Research

    Comparative in vitro cytotoxic, anti-inflammatory and anti-microbiological activities of two indigenous Venda medicinal plants

    The Vhembe region of the Limpopo province has a rich tradition of medicinal plants use. Traditionally, boiled roots of Ziziphus mucronata are used in the treatment of boils, general swelling and other skin infect...

    M. T. Sigidi, C. P. Anokwuru, T. Zininga, M. P. Tshisikhawe, A. Shonhai, I. D. I. Ramaite, A. N. Traoré and N. Potgieter

    Translational Medicine Communications 2016 1:9

    Published on: 9 December 2016

  8. Research

    Thymosin beta 4 treatment improves left ventricular function after myocardial infarction and is related to Up-regulation of chitinase 3-like-1 in mice

    Thymosin beta 4 is a promising agent in preclinical regenerative and cardioprotection research. After myocardial injury it improves cell survival, reduces inflammation and activates epicardial progenitor cells...

    Christoffer Stark, Mikko Helenius, Pekka Taimen, Rasmus Kentala, Antti Saraste, Tero-Pekka Alastalo, Timo Savunen and Juha Koskenvuo

    Translational Medicine Communications 2016 1:8

    Published on: 7 December 2016

  9. Research

    Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies

    IgA nephropathy (IgAN) exhibits a variable course ranging from a benign condition to progressive renal failure with a high proportion of patients undergoing end-stage renal disease in the long term. It is uncl...

    Patrizia Viola, Lucia Centurione, Paolo Felaco, Giuseppe Lattanzio, Tommaso D’Antuono, Marcella Liberatore, Roberta Di Pietro, Franco Oreste Ranelletti, Mario Bonomini and Francesca Bianca Aiello

    Translational Medicine Communications 2016 1:7

    Published on: 21 November 2016

  10. Protocol

    A novel clinical approach to evaluating changes in fat oxidation in healthy, overnight-fasted subjects

    Obesity is characterized by impaired fat oxidation, and, therefore, the development of therapeutics designed to enhance fat oxidation for treating obesity is a growing focus in drug discovery. Evaluating such ...

    Stephanie A. Parsons, Karen P. Jones, Fanchao Yi, Christopher P. Bock, Christopher J. Petucci, Stella K. Betancourt, Stephen J. Gardell and Steven R. Smith

    Translational Medicine Communications 2016 1:6

    Published on: 6 October 2016

  11. Research

    Optimization of CFTR-mRNA transfection in human nasal epithelial cells

    Cystic fibrosis (CF) is the most common life-threatening inherited disease in the Caucasian population. It is caused by genetic defects in the cystic fibrosis transmembrane conductance regulator gene (CFTR), a cA...

    Elena Fernández Fernández, Nadine Bangel-Ruland, Katja Tomczak and Wolf-Michael Weber

    Translational Medicine Communications 2016 1:5

    Published on: 4 October 2016

  12. Research

    CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

    Breast Cancer in the Middle East and North Africa region (MENA) occurs in a younger age group of patients and is more aggressive than in Europe and North America. Little is known about the presence of immune i...

    Mahmoud Mohamed, Hina Sarwath, Nada Salih, Devendra Bansal, Prem Chandra, Nazik E. Husain, Lotfi Chouchane, Ali A. Sultan and Shahinaz Bedri

    Translational Medicine Communications 2016 1:4

    Published on: 1 October 2016

  14. Research

    Membrane cholesterol depletion reduces breast tumor cell migration by a mechanism that involves non-canonical Wnt signaling and IL-10 secretion

    Migration and invasion are hallmarks of cancer cells that allow their dissemination to other tissues. Studying the cellular and molecular basis of cancer cell migration can help us to understand and control ca...

    Fabiana Sélos Guerra, Luzia da Silva Sampaio, Sandra Konig, Martin Bonamino, Maria Isabel Doria Rossi, Manoel Luis Costa, Patricia Fernandes and Claudia Mermelstein

    Translational Medicine Communications 2016 1:3

    Published on: 30 August 2016

  15. Research

    T-helper-1, T-helper-17, T-regulatory lymphocytes in hypertensive patients with diabetes mellitus type 2 or impaired glucose tolerance: association with clinical and metabolic parameters in a case control study

    Low-grade inflammation plays significant role in the development of diabetes mellitus type 2 (DM2) and impaired glucose tolerance (IGT), but immune regulatory mechanisms involved in these processes are studied...

    Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Koshelskaya, Irina V. Vinnizkaya and Sergey V. Popov

    Translational Medicine Communications 2016 1:2

    Published on: 30 August 2016

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