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  1. Insulin resistance is a major pathogenic factor that plays a crucial role in the development of metabolic syndrome and has been proposed as one of its underlying causes. Most diagnostic criteria for metabolic ...

    Authors: Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun, Adham Abu Taha, Faris Abushamma and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2024 9:6
  2. Dysregulation of cellular processes related to protein folding and trafficking leads to the accumulation of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress. Cells cope with ER stress...

    Authors: Fernanda Dittrich Oliveira, Rafael Paschoal de Campos, Luiza Cherobini Pereira, Lisiane B. Meira and Guido Lenz
    Citation: Translational Medicine Communications 2024 9:5
  3. The 26S proteasome is a large intracellular multiprotein complex, that plays a homeostatic role by degrading proteins that have been tagged by ubiquitin. It is composed of 64 subunits assembled according to a ...

    Authors: Vito Spataro and Antoine Buetti-Dinh
    Citation: Translational Medicine Communications 2024 9:4
  4. Arsenic (ATO) and retinoic acid (ATRA) are successfully used as chemotherapy-free regimens to treat acute APL. Compared to traditional chemotherapy approaches, this therapy evokes fewer haematological side eff...

    Authors: Anna Thunström Salzer and Constantin F. Urban
    Citation: Translational Medicine Communications 2024 9:3
  5. iMN013 (5-aza-2',2'-difluorodeoxycytidine), a DNA methyl transferase inhibitor and ribonucleotide reductase inhibitor, and its prodrug iMN041 (3',5'-di-trimethylsilyl-2',2'-difluro-5- azadeoxycytidine), have b...

    Authors: Richard Daifuku, Yu Zhang, Jingjing Wang and Qingyang Gu
    Citation: Translational Medicine Communications 2024 9:2
  6. Late-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that profound changes in the monocyte turnover (MTO) rate in rhesus macaques i...

    Authors: Laurent Zablocki-Thomas, Amir Ardeshir, Naofumi Takahashi, Kevin S. White, Cinar Efe Sumer, Zoey K. Wallis, Elizabeth S. Didier, Woong-Ki Kim, Kenneth C. Williams and Marcelo J. Kuroda
    Citation: Translational Medicine Communications 2024 9:1
  7. Androgenetic alopecia (AGA), one of the most common types of hair loss, is associated with oxidative stress, inflammation and aging. Derinat, a transient receptor potential canonical channels (TRPCs) inhibitor...

    Authors: Ching-Ying Wu, Wei-Chiao Chen, Cheng-Hsu Hsieh, Yun-Fang Liang, Wei-Ju Li, Hao Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang and Wen-Li Hsu
    Citation: Translational Medicine Communications 2023 8:25
  8. Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited condition associated primarily with PKD1 and PKD2 genes. However, ADPKD patients in Latin America have had limited access to comprehensiv...

    Authors: Esperanza Bayyad, Anita Plaza, Jaime Klenner, Patricio Downey, Paulina Salas, Daniela Maragaño, Patricio Herrera, Paula Lehmann, Lily Quiroz, María Jesus Zavala, Karen Orostica, Claudio Flores, Leopoldo Ardiles, Jorge Maturana and Paola Krall
    Citation: Translational Medicine Communications 2023 8:24
  9. The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is critical for maintaining ionic homeostasis and limiting the entry of deleterious agents. BLB integrity is disrupted by bact...

    Authors: Silvia Murillo-Cuesta, Ester Lara, Jose M. Bermúdez-Muñoz, Elena Torres-Campos, Lourdes Rodríguez-de la Rosa, Pilar López-Larrubia, Signe R. Erickson and Isabel Varela-Nieto
    Citation: Translational Medicine Communications 2023 8:23
  10. Escherichia coli is a facultative anaerobic bacterium that normally resides in the gastrointestinal tract of humans and animals but can cause diarrhea and enteritis. MPX is an antimicrobial peptide extracted from...

    Authors: Xueqin Zhao, Weiyu Luo, Lei Wang, Chunling Zhu, Xianghong Xue, Xiaojing Xia, Xilong Wu, Yueyu Bai and Jianhe Hu
    Citation: Translational Medicine Communications 2023 8:22
  11. Clonal hematopoiesis (CH) describes the aging-associated expansion of mutant hematopoietic cell populations. In various cohorts, CH has been associated with increased morbidity and mortality from non-hematolog...

    Authors: Cathy Smith, Bala B. Burugula, Morgan A. Jones, Qing Li, Jacob O. Kitzman and Terrence N. Wong
    Citation: Translational Medicine Communications 2023 8:20
  12. A gluten-free diet (GFD) has become one of the most popular eating plans and is essential for managing gluten-related medical conditions, signs, and symptoms. Therefore, we performed a bibliometric analysis of...

    Authors: Sa ’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moath Hamdallah and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2023 8:18
  13. Despite the successes of checkpoint inhibitors targeting T-cell receptors, clinical efficacy is highly cancer-dependent and subject to high inter-individual variability in treatment outcome. The ability to pre...

    Authors: Juan Miguel Tenorio-Pedraza, Jörg Lippert, Rolf Burghaus and Christian Scheerans
    Citation: Translational Medicine Communications 2023 8:17
  14. Media fills are used to demonstrate the adequacy of the aseptic conditions of a pharmaceutical production process, according to good manufacturing practice (GMP), using a growth medium in place of the product ...

    Authors: Ivana Ferrero, Sara Castiglia, Aloe Adamini, Alessandra Mandese, Francesca Sismondi, Deborah Rustichelli, Marco Leone, Giuseppe Pinnetta, Lucia Giordanengo, Katia Mareschi and Franca Fagioli
    Citation: Translational Medicine Communications 2023 8:16
  15. Gene-modified cell therapy with regulatory T cells (Tregs) is a promising approach to prevent graft rejection and induce immunological tolerance in organ transplantation. We are developing a cell therapy compr...

    Authors: Hervé Bastian, Nadia Lounnas-Mourey, Pierre Heimendinger, Benjamin L. Hsu, Katharina H. Schreeb, Claire Chapman, Emily Culme-Seymour, Gillian F. Atkinson and Diego Cantarovich
    Citation: Translational Medicine Communications 2023 8:15
  16. Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) s...

    Authors: Jodie L. Morris, Peter C. McEwen, Hayley L. Letson and Geoffrey P. Dobson
    Citation: Translational Medicine Communications 2023 8:14
  17. Management of mechanically ventilated patients can be improved with monitoring of key pulmonary function parameters that facilitate individualization and optimization. The VQm Pulmonary Health Monitor™ (PHM) (...

    Authors: Maximilian Edlinger-Stanger, Caroline Fritz, Hanna C. McGregor, Spencer L. Bustin, Nathan Ayoubi, Harpreet K. Bath, Johannes Müller, Sebastian Kühnl-Brady, Thomas Schweiger, Julia Jedamzik, Marita Windpassinger, Michael Hiesmayr, Bernard P. Cholley and Neal W. Fleming
    Citation: Translational Medicine Communications 2023 8:13
  18. Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutroph...

    Authors: Victoria L. M. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, David B. Seder, Nelson Ruiz-Opazo and Allan J. Walkey
    Citation: Translational Medicine Communications 2023 8:12
  19. Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient’s cells...

    Authors: Shivani Thoidingjam, Sushmitha Sriramulu, Svend Freytag, Stephen L. Brown, Jae Ho Kim, Indrin J. Chetty, Farzan Siddiqui, Benjamin Movsas and Shyam Nyati
    Citation: Translational Medicine Communications 2023 8:11
  20. Rheumatoid Arthritis is one of the most common autoimmune diseases, causing irreversible joint damage and disability. Methotrexate (MTX) is the gold standard drug for this. The low cost, easy availability and ...

    Authors: Harjit Singh Nalwa, Peeyush Prasad, Nirmal Kumar Ganguly, Ved Chaturvedi and Shivani Arora Mittal
    Citation: Translational Medicine Communications 2023 8:10
  21. Preclinical studies have demonstrated the potential use of induced pluripotent stem cells (iPSCs) to treat cardiovascular disease (CVD). In vivo preclinical studies conducted on animal models (murine, porcine,...

    Authors: Ryan Bellman, Jishizhan Chen, Lidan Chen, Nikolitsa Nomikou, Janice Tsui, George Hamilton and Wenhui Song
    Citation: Translational Medicine Communications 2023 8:9
  22. Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found o...

    Authors: John Mukisa, Marion Amujal, Obondo J. Sande, Moses L. Joloba, Daudi Jjingo, David P. Kateete, Graeme Mardon, Mogomotsi Matshaba, Neil Hanchard and Jill A. Hollenbach
    Citation: Translational Medicine Communications 2023 8:8
  23. Electronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not w...

    Authors: Cosby G. Arnold, Brandon Sonn, Frederick J. Meyers, Alexis Vest, Richie Puls, Estelle Zirkler, Michelle Edelmann, Ian M. Brooks and Andrew A. Monte
    Citation: Translational Medicine Communications 2023 8:7
  24. Prophylactic platelet transfusion is given to patients when the platelet count is less than ten thousand to prevent clinically significant bleeding till platelet engraftment is documented. Despite a very low p...

    Authors: Zainab Ghias, Uzma Zaidi, Munira Borhany, Shafaq Abdul Samad, Noureen Durrani, Mushkbar Fatima, Sidra Zafar, Aisha Jamal and Tahir Shamsi
    Citation: Translational Medicine Communications 2023 8:6
  25. This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment.

    Authors: Joaquina C. Baranda, Ghulam Rehman Mohyuddin, Andrés M. Bur, Yelizaveta Shnayder, Kyle R. Sweeney, Kiran Kakarala, Megan Prouty, Harsh Pathak, Rajni Puri, Amrita Mitra, Rashna Madan, M. Laird Forrest, Aric Huang, Scott Weir, Andrew K. Godwin, Nabil A. Alhakamy…
    Citation: Translational Medicine Communications 2023 8:5
  26. Intrathecal (IT) catheter delivery of baclofen via continuous infusion using an implantable pump is an important means of treating patients with severe spasticity. We evaluated the impact of IT catheter tip pl...

    Authors: Brian A. Duclos, Cindy Roegge, Howard Dobson, Scott Haller, Jeff Bodner, Sanjana Pannem, Janelle Gesaman and Amin Nourmohammadi
    Citation: Translational Medicine Communications 2023 8:4
  27. The BRAF and MEK inhibitors combined strategies have dramatically changed the outcome of BRAF-mutated metastatic melanoma patients. However, despite the initial promising results, the onset of primary or acqui...

    Authors: Valentina Belli, Stefania Napolitano, Vincenzo De Falco, Gabriella Suarato, Alessandra Perrone, Luigi Pio Guerrera, Giulia Martini, Carminia Maria Della Corte, Erika Martinelli, Floriana Morgillo, Mimmo Turano, Maria Furia, Giuseppe Argenziano, Davide Ciardiello, Fortunato Ciardiello and Teresa Troiani
    Citation: Translational Medicine Communications 2023 8:3
  28. Hypoxic zones exist in solid tumors, where oxygen levels are significantly lower than in normal tissues. Hypoxia makes chemo-radiation therapeutics less effective and renders the metastatic potential more favo...

    Authors: Muzamil Farooq, Gh. Rasool Bhat, Syed Besina, Natasha Thakur, Sheikh Zahoor, Rafiq A. Rather, Ifra Mushtaq, Sadaf Dar, Bilal Rah, Ajaz A. Bhat, Muzafar A. Macha and Dil Afroze
    Citation: Translational Medicine Communications 2023 8:2
  29. RLS-0071 is a novel 15 amino acid peptide dual-targeting anti-inflammatory inhibitor of complement and neutrophil effectors. RLS-0071 inhibits classical complement pathway activation at C1 and blocks the enzym...

    Authors: Jessica Goss, Pamela Hair, Parvathi Kumar, Giuseppina Iacono, Laura Redden, Gaetano Morelli, Neel Krishna, Ulrich Thienel and Kenji Cunnion
    Citation: Translational Medicine Communications 2023 8:1
  30. Acute inflammation is the body’s immediate and well-coordinated response to injury, which if not resolved can lead to a state of chronic inflammation and is an important component of aging-associated pathologi...

    Authors: Asha Jaja-Chimedza, Steven Hirsh, Dainian Bruce, Tony Bou-Sliman, Steven Joyal and Andrew G. Swick
    Citation: Translational Medicine Communications 2022 7:25
  31. Clinical translation from bench to bedside often remains challenging even despite promising preclinical evidence. Among many drivers like biological complexity or poorly understood disease pathology, preclinic...

    Authors: Natascha Ingrid Drude, Lorena Martinez-Gamboa, Meggie Danziger, Anja Collazo, Silke Kniffert, Janine Wiebach, Gustav Nilsonne, Frank Konietschke, Sophie K. Piper, Samuel Pawel, Charlotte Micheloud, Leonhard Held, Florian Frommlet, Daniel Segelcke, Esther M. Pogatzki-Zahn, Bernhard Voelkl…
    Citation: Translational Medicine Communications 2022 7:24
  32. Diabetic dyslipidemia is a complex multidimensional abnormality. However, earlier studies did not focus on the prevalence of various patterns of dyslipidemia. We categorized dyslipidemia into three groups. Sin...

    Authors: Amirhossein Yadegar, Fatemeh Mohammadi, Soghra Rabizadeh, Reihane Qahremani, Alireza Esteghamati and Manouchehr Nakhjavani
    Citation: Translational Medicine Communications 2022 7:23
  33. The pathogenesis of the novel described multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) is still debated as it is not clear if they are the same or different nosological entitie...

    Authors: Alice Castaldo, Carolina D’Anna, Monica Gelzo, Antonietta Giannattasio, Marco Maglione, Stefania Muzzica, Maddalena Raia, Giulia Scalia, Lorella Tripodi, Giuseppe Castaldo, Vincenzo Tipo, Domenico Grieco and Michela Grieco
    Citation: Translational Medicine Communications 2022 7:22
  34. Many variables have been studied in cancer patients. Nevertheless, an study that analyzes simultaneously physical, functional and biological variables in they from clinical, physical and statistical points of ...

    Authors: Justa Carmen Columbié Regüeiferos, Taira Teresa Batista Luna, Soraida Cándida Acosta Brooks, Maylet Planas Rodriguez, Larisa Zamora Matamoros, Beatríz Legrá Rodríguez, Arnolis Poll Fernández, José Luis García Bello, Arquímedes Montoya Pedrón, Maraelys Morales González, Julio Cesar Núñez Garcia, Esmirna Cascaret Fonseca and Luis Enrique Bergues Cabrales
    Citation: Translational Medicine Communications 2022 7:21
  35. Bloodstream infections (BSIs) are among the most lethal complications of liver transplantation (LT). Natural killer (NK) cells are an important component of innate immunity and play an essential role in infect...

    Authors: Masahiro Ohira, Yuki Imaoka, Koki Sato, Koki Imaoka, Ryosuke Nakano, Naoki Tanimine, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka and Hideki Ohdan
    Citation: Translational Medicine Communications 2022 7:19
  36. Obesity increases the chance of developing insulin resistance. Numerous inflammatory markers have been linked to an increased risk of insulin resistance in obese individuals. Therefore, we performed a bibliome...

    Authors: Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2022 7:18
  37. In the present study, the effect(s) of the immunomodulatory drug GLS-1027 on various cell types involved in inflammation were investigated. GLS-1027 reduced LPS-stimulated secretion of pro-inflammatory cytokin...

    Authors: Sagar B Kudchodkar, Paolo Fagone, Omkar U Kawalekar, Moonsup Jeong, Christine C Roberts, Hyojin Lee, Youngran Cho, Areum Gil, Yeeun Oh, Bohyun Jeon, Gee Ho Park, Young K Park, Ferdinando Nicoletti, Joel N Maslow and Kar Muthumani
    Citation: Translational Medicine Communications 2022 7:16
  38. Non-healing surgical wounds is a risk in certain patients. Recently, allogenic plasma-rich-platelet (PRP) is used such as regenerative treatment of different non-healing surgical wounds.

    Authors: Jesús Seco-Calvo, Julia Vidán-Estévez and Sergio Sánchez-Herráez
    Citation: Translational Medicine Communications 2022 7:14
  39. Translational research aims at reducing gaps between fundamental scientific discoveries and real-world applications. However, the trajectory of most scientific discoveries along the translation research contin...

    Authors: Gardy Lavertu, Ella Diendere, France Légaré, Hervé Tchala Vignon Zomahoun, Alfred Kodjo Toi, Mathilde Leblond, Nathalie Rheault, Étienne Audet-Walsh, Marie-Claude Beaulieu, Ali Ben Charif, Virginie Blanchette, Jean-Pierre Després, André Gaudreau, Caroline Rhéaume, Marie-Claude Tremblay and Jean-Sébastien Paquette
    Citation: Translational Medicine Communications 2022 7:13
  40. Elevated serum levels of serum amyloid A (SAA) are associated with increased risk of cardiovascular disease. In this study, we examine associations between allelic variation in the rs11024595 single nucleotide...

    Authors: Sofie Ahlin, Maja Löfgren, Magdalena Taube, Johanna C. Andersson-Assarsson, Markku Peltonen, Per-Arne Svensson, Peter Jacobson, Lena MS Carlsson and Kajsa Sjöholm
    Citation: Translational Medicine Communications 2022 7:12
  41. Collaboration between biomedical research and community-based primary health care actors is essential to translate evidence into clinical practice. However, little is known about the characteristics and impact...

    Authors: Jean-Sébastien Paquette, Hervé Tchala Vignon Zomahoun, Ella Diendere, Gardy Lavertu, Nathalie Rheault, Alfred Kodjo Toi, Mathilde Leblond, Étienne Audet-Walsh, Marie-Claude Beaulieu, Ali Ben Charif, Virginie Blanchette, Jean-Pierre Després, André Gaudreau, Caroline Rhéaume, Marie-Claude Tremblay and France Légaré
    Citation: Translational Medicine Communications 2022 7:11
  42. Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis and represents an important global public health issue. Single-nucleotide polymorphisms and INDELs are common genetic ...

    Authors: Débora C. R. F. Porchera, Diana F. V. B. Leal, Ana C. O. Braga, Pablo D. C. Pinto, Mayara N. Santana da Silva, Lucas C. Bezerra Santos, Cintia H. Braga da Silva, Giovana E. da Costa, Maria Clara da C. Barros, Aidalucy do S. C. de Athayde, Amanda de N Cohen-Paes, Cleonardo A. da Silva, Paulo P. de Assumpção, Ândrea K. C. Ribeiro-dos-Santos, Sidney E. B. dos Santos, Marianne R. Fernandes…
    Citation: Translational Medicine Communications 2022 7:10
  43. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a low-abundance membrane protein. The dysfunction of CFTR protein is the fundamental cause of cystic fibrosis (CF), a fatal genetic dis...

    Authors: Hui Wang, Yunxiang Dai, Nicholas Clark, Lianne Boeglin, Caroline Woo, Richard Wooster, Gang Sun and James C. Sullivan
    Citation: Translational Medicine Communications 2022 7:9
  44. Diffuse intrinsic pontine glioma (DIPG) is a notoriously difficult tumor to treat, with an overall survival of DIPG patients being only 11 months. One of the major obstacles for the effective treatment of DIPG...

    Authors: Rianne Haumann, John I. Bianco, Piotr M. Waranecki, Pieter J. Gaillard, Gert Storm, Mario Ries, Dannis G. van Vuurden, Gertjan J. L. Kaspers and Esther Hulleman
    Citation: Translational Medicine Communications 2022 7:8

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