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  1. Bone marrow aplasia is a common feature in acute myeloid leukemia (AML) patients during their remission induction treatment, and is associated with potential complications such as bleeding, infection and anemi...

    Authors: Eva R. Smit, Diana Muñoz Sandoval, Iris C. Kreft, Pieter F. van der Meer, Carmen van der Zwaan, Jan Voorberg, Paula F. Ypma, Arie J. Hoogendijk, Jean-Louis Kerkhoffs and Maartje van den Biggelaar
    Citation: Translational Medicine Communications 2024 9:27
    Content type: Research Published on:

  2. Atheroma is a serious atherosclerotic lesion related to plaque rupture, thrombosis, and ischemic disease. To clarify the pathogenesis of human atheroma, particularly the formation of the liponecrotic tissue in...

    Authors: Kazunori Nakagawa and Yutaka Nakashima
    Citation: Translational Medicine Communications 2024 9:26
    Content type: Research Published on:

  3. Antiretroviral therapy (ART) has significantly improved the prognosis for people living with human immunodeficiency virus (PLWH). However, alterations in the gut microbiota of PLWH affect their metabolic envir...

    Authors: Aya Ishizaka, Michiko Koga, Taketoshi Mizutani, Yutaka Suzuki, Tetsuro Matano and Hiroshi Yotsuyanagi
    Citation: Translational Medicine Communications 2024 9:25
    Content type: Research Published on:

  4. Breast cancer (BC) is the primary cause of cancer-related deaths among women. BH3 only proteins expression profile in BC has been linked to chemotherapy and treatment outcomes. Clinical biomarkers provide insi...

    Authors: Taha Abd-ElSalam Ashraf Taha, Shatha Omar, Nada K. Abdelsattar, Mohamed Abd-ElGawad Mahmoud, Mahmoud M. Kamel and Nadia M. Hamdy
    Citation: Translational Medicine Communications 2024 9:24
    Content type: Review Published on:

  5. Delirium, characterized by a sudden onset of neuropsychiatric symptoms, is a highly prevalent syndrome whose diagnosis is defined solely through clinical evaluation. Due to the often challenging reliability of...

    Authors: Fabio Kenji Sugawara, Gabriel Mattucci Domingues Pereira, Victor Matheus Ribeiro Baylão, Rebeca Souza da Silva, Matheus Menão Mochetti, Júlio César Garcia Alencar and Heraldo Possolo de Souza
    Citation: Translational Medicine Communications 2024 9:23
    Content type: Review Published on:

  6. The incidence of brain diseases in humans is increasing as we experience a worldwide ageing of the population. Treatment for such diseases is still only symptomatic as there are almost no disease-modifying the...

    Authors: Katrina Albert, Gundars Goldsteins, Sara Kälvälä, Jukka Jolkkonen and Šárka Lehtonen
    Citation: Translational Medicine Communications 2024 9:22
    Content type: Review Published on:

  7. Many tumors contain hypoxic microenvironments caused by inefficient tumor vascularization. Hypoxic tumors have been shown to resist conventional cancer therapies. Hypoxic cancer cells rely on glucose to meet t...

    Authors: Karen Schmidt, Amber Thatcher, Albert Grobe, Pamela Broussard, Linda Hicks, Haiwei Gu, Lesley G Ellies, Dorothy D. Sears, Leonid Kalachev and Eugene Kroll
    Citation: Translational Medicine Communications 2024 9:21
    Content type: Research Published on:

  8. Rett syndrome (OMIM 312750) is a rare neurodevelopmental disorder caused by de novo mutations in the Methyl-CpG Binding Protein 2 (MeCP2) gene located on the X-chromosome, typically affecting girls. Rett syndr...

    Authors: Rodrigo Lata, Liesbeth Steegmans, Ranie Kellens, Marnik Nijs, Hugo Klaassen, Matthias Versele, Frauke Christ and Zeger Debyser
    Citation: Translational Medicine Communications 2024 9:20
    Content type: Research Published on:

  9. SARS-CoV-2 caused an outbreak in late December 2019. It has been suggested that gut microbiota dysbiosis influences the severity, mortality, and quality of life of patients with COVID-19. So, identifying the g...

    Authors: Seyed Aria Nejadghaderi, Ehsan Nazemalhosseini-Mojarad, Asra Fazlollahi, Ali Pirsadeghi, Ainaz Khalili, Rasoul Ebrahimi and Nima Rezaei
    Citation: Translational Medicine Communications 2024 9:19
    Content type: Protocol Published on:

  10. We aimed to investigate the development of synovial fibrosis in vitro and how the fibrosis can be halted. Synovial fibrosis causes joint stiffness in arthritic diseases. The pathway of the fibrotic growth fact...

    Authors: Sofie Falkenløve Madsen, Sarah Spliid Madsen, Alexander Scheller Madrid, Mikkel Rathsach Andersen, Anne-Christine Bay-Jensen and Christian S. Thudium
    Citation: Translational Medicine Communications 2024 9:18
    Content type: Research Published on:

  11. Tissue engineering is a multidisciplinary field that combines principles from cell biology, bioengineering, material sciences, medicine and surgery to create functional and viable bioproducts that can be used ...

    Authors: Renan Gonçalves Leonel da Silva, Larry Au and Alessandro Blasimme
    Citation: Translational Medicine Communications 2024 9:17
    Content type: Research Published on:

  12. Uterus tissue engineering aims to repair a dysfunctional uterus that causes infertility, e.g., after significant scarring from benign or malign resection procedures. Decellularized uterine tissue provided rege...

    Authors: Edina Sehic, Lucía de Miguel-Gómez, Emy Thorén, Johan Sameus, Henrik Bäckdahl, Mihai Oltean, Mats Brännström and Mats Hellström
    Citation: Translational Medicine Communications 2024 9:16
    Content type: Research Published on:

  13. Immune Checkpoint Inhibitor (ICI) immunotherapy is most effective in immune effector cell infiltrated ‘hot’ tumor lesions, such as occurs in deficient mismatch repair, microsatellite instability high (dMMR/MSI...

    Authors: Ariel Hirschfeld, Daniel Gurell and Michael Har-Noy
    Citation: Translational Medicine Communications 2024 9:15
    Content type: Research Published on:

  14. Pancreatic cancer (PC) remains a significant healthcare challenge due to its aggressive nature and poor prognosis. The current gold standard that combines imaging modalities, endoscopy, and biopsies has limite...

    Authors: Federica Dibennardo, Onur Fidaner, Les Bogdanowicz, Daniel S. Gehrke, Donato Ceres, Margaret C. John, Constantine H. Bovalis, Erik M. Kundro, Alexander Grycuk, Karla Castellanos, Adonis Coleman, Kavya Sudhir, Jorge Heneche, Jose Acebedo, Angel Jimenez, Isaac Raijman…
    Citation: Translational Medicine Communications 2024 9:14
    Content type: Research Published on:

  15. In recent years, there has been a noteworthy increase in research exploring the relationship between gut microbiota and bariatric surgery. This increase can be attributed to the growing recognition of the impo...

    Authors: Sa’ed H. Zyoud, Muna Shakhshir, Abdelkarim Barqawi, Amani S. Abushanab, Amer Koni, Shadi Khilfeh, Moyad Shahwan, Ammar A. Jairoun, Adham Abu Taha, Faris Abushamma and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2024 9:13
    Content type: Research Published on:

  16. Parkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions of elderly individuals worldwide. Clinically, PD is diagnosed based on the presentation of motoric symptoms. Other methods ...

    Authors: Teddy J. W. Tng, Barbara Wing Yan Wong, Esther H. Y. Sim, Eng King Tan, Wilson W. B. Goh and Kah-Leong Lim
    Citation: Translational Medicine Communications 2024 9:12
    Content type: Review Published on:

  17. The COVID-19 pandemic and the consequences of safety measures, such as lockdowns, have impacted not only the physical health of individuals but also their lifestyle, psychosocial health, and mental health. In ...

    Authors: Amer A. Koni, Israa Hasan, Maisa A. Nazzal, Siwar Haj, Hamza K. Joma, Amani S. Abushanab and Sa’ed H. Zyoud
    Citation: Translational Medicine Communications 2024 9:11
    Content type: Research Published on:

  18. Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by an intense infiltration of eosinophils into the esophageal epithelium. When not adequately controlled, eosinophilic inflammat...

    Authors: Ezekiel J. Haugen, Andrea K. Locke, Hernán Correa, Justin S. Baba, Anita Mahadevan-Jansen and Girish Hiremath
    Citation: Translational Medicine Communications 2024 9:10
    Content type: Research Published on:

  19. SARS-CoV-2 belongs to the coronaviridae family and infects human cells by directly interacting with the angiotensin-converting enzyme-2 (ACE-2) through the viral Spike Protein (SP). While vaccines are crucial, mu...

    Authors: Alessandro Del Re, Silvia Basili Franzin, Jie Lu, Irene Palenca, Aurora Zilli, Federico Pepi, Anna Troiani, Luisa Seguella, Marcella Pesce, Giovanni Esposito, Giovanni Sarnelli and Giuseppe Esposito
    Citation: Translational Medicine Communications 2024 9:9
    Content type: Research Published on:

  20. Kidney stones, or renal nephrolithiasis, are common and dangerous, increasing the risk of chronic kidney disease. Dietary manipulation is essential for the prevention and recurrence of kidney stones. Research ...

    Authors: Sa’ed H. Zyoud, Faris Abushamma, Husam Salameh, Amani S. Abushanab, Amer Koni, Adham Abu Taha, Samah W. Al-Jabi, Moyad Shahwan, Ammar A. Jairoun and Muna H. Shakhshir
    Citation: Translational Medicine Communications 2024 9:8
    Content type: Research Published on:

  22. Insulin resistance is a major pathogenic factor that plays a crucial role in the development of metabolic syndrome and has been proposed as one of its underlying causes. Most diagnostic criteria for metabolic ...

    Authors: Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun, Adham Abu Taha, Faris Abushamma and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2024 9:6
    Content type: Research Published on:

  23. Dysregulation of cellular processes related to protein folding and trafficking leads to the accumulation of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress. Cells cope with ER stress...

    Authors: Fernanda Dittrich Oliveira, Rafael Paschoal de Campos, Luiza Cherobini Pereira, Lisiane B. Meira and Guido Lenz
    Citation: Translational Medicine Communications 2024 9:5
    Content type: Research Published on:

  24. The 26S proteasome is a large intracellular multiprotein complex, that plays a homeostatic role by degrading proteins that have been tagged by ubiquitin. It is composed of 64 subunits assembled according to a ...

    Authors: Vito Spataro and Antoine Buetti-Dinh
    Citation: Translational Medicine Communications 2024 9:4
    Content type: Research Published on:

  25. Arsenic (ATO) and retinoic acid (ATRA) are successfully used as chemotherapy-free regimens to treat acute APL. Compared to traditional chemotherapy approaches, this therapy evokes fewer haematological side eff...

    Authors: Anna Thunström Salzer and Constantin F. Urban
    Citation: Translational Medicine Communications 2024 9:3
    Content type: Research Published on:

    The Correction to this article has been published in Translational Medicine Communications 2024 9:7

  26. iMN013 (5-aza-2',2'-difluorodeoxycytidine), a DNA methyl transferase inhibitor and ribonucleotide reductase inhibitor, and its prodrug iMN041 (3',5'-di-trimethylsilyl-2',2'-difluro-5- azadeoxycytidine), have b...

    Authors: Richard Daifuku, Yu Zhang, Jingjing Wang and Qingyang Gu
    Citation: Translational Medicine Communications 2024 9:2
    Content type: Research Published on:

  27. Late-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that profound changes in the monocyte turnover (MTO) rate in rhesus macaques i...

    Authors: Laurent Zablocki-Thomas, Amir Ardeshir, Naofumi Takahashi, Kevin S. White, Cinar Efe Sumer, Zoey K. Wallis, Elizabeth S. Didier, Woong-Ki Kim, Kenneth C. Williams and Marcelo J. Kuroda
    Citation: Translational Medicine Communications 2024 9:1
    Content type: Research Published on:

  28. Androgenetic alopecia (AGA), one of the most common types of hair loss, is associated with oxidative stress, inflammation and aging. Derinat, a transient receptor potential canonical channels (TRPCs) inhibitor...

    Authors: Ching-Ying Wu, Wei-Chiao Chen, Cheng-Hsu Hsieh, Yun-Fang Liang, Wei-Ju Li, Hao Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang and Wen-Li Hsu
    Citation: Translational Medicine Communications 2023 8:25
    Content type: Research Published on:

  29. Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited condition associated primarily with PKD1 and PKD2 genes. However, ADPKD patients in Latin America have had limited access to comprehensiv...

    Authors: Esperanza Bayyad, Anita Plaza, Jaime Klenner, Patricio Downey, Paulina Salas, Daniela Maragaño, Patricio Herrera, Paula Lehmann, Lily Quiroz, María Jesus Zavala, Karen Orostica, Claudio Flores, Leopoldo Ardiles, Jorge Maturana and Paola Krall
    Citation: Translational Medicine Communications 2023 8:24
    Content type: Research Published on:

  30. The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is critical for maintaining ionic homeostasis and limiting the entry of deleterious agents. BLB integrity is disrupted by bact...

    Authors: Silvia Murillo-Cuesta, Ester Lara, Jose M. Bermúdez-Muñoz, Elena Torres-Campos, Lourdes Rodríguez-de la Rosa, Pilar López-Larrubia, Signe R. Erickson and Isabel Varela-Nieto
    Citation: Translational Medicine Communications 2023 8:23
    Content type: Research Published on:

  31. Escherichia coli is a facultative anaerobic bacterium that normally resides in the gastrointestinal tract of humans and animals but can cause diarrhea and enteritis. MPX is an antimicrobial peptide extracted from...

    Authors: Xueqin Zhao, Weiyu Luo, Lei Wang, Chunling Zhu, Xianghong Xue, Xiaojing Xia, Xilong Wu, Yueyu Bai and Jianhe Hu
    Citation: Translational Medicine Communications 2023 8:22
    Content type: Research Published on:

  32. Clonal hematopoiesis (CH) describes the aging-associated expansion of mutant hematopoietic cell populations. In various cohorts, CH has been associated with increased morbidity and mortality from non-hematolog...

    Authors: Cathy Smith, Bala B. Burugula, Morgan A. Jones, Qing Li, Jacob O. Kitzman and Terrence N. Wong
    Citation: Translational Medicine Communications 2023 8:20
    Content type: Research Published on:

  35. A gluten-free diet (GFD) has become one of the most popular eating plans and is essential for managing gluten-related medical conditions, signs, and symptoms. Therefore, we performed a bibliometric analysis of...

    Authors: Sa ’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moath Hamdallah and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2023 8:18
    Content type: Research Published on:

  36. Despite the successes of checkpoint inhibitors targeting T-cell receptors, clinical efficacy is highly cancer-dependent and subject to high inter-individual variability in treatment outcome. The ability to pre...

    Authors: Juan Miguel Tenorio-Pedraza, Jörg Lippert, Rolf Burghaus and Christian Scheerans
    Citation: Translational Medicine Communications 2023 8:17
    Content type: Research Published on:

  37. Media fills are used to demonstrate the adequacy of the aseptic conditions of a pharmaceutical production process, according to good manufacturing practice (GMP), using a growth medium in place of the product ...

    Authors: Ivana Ferrero, Sara Castiglia, Aloe Adamini, Alessandra Mandese, Francesca Sismondi, Deborah Rustichelli, Marco Leone, Giuseppe Pinnetta, Lucia Giordanengo, Katia Mareschi and Franca Fagioli
    Citation: Translational Medicine Communications 2023 8:16
    Content type: Research Published on:

  38. Gene-modified cell therapy with regulatory T cells (Tregs) is a promising approach to prevent graft rejection and induce immunological tolerance in organ transplantation. We are developing a cell therapy compr...

    Authors: Hervé Bastian, Nadia Lounnas-Mourey, Pierre Heimendinger, Benjamin L. Hsu, Katharina H. Schreeb, Claire Chapman, Emily Culme-Seymour, Gillian F. Atkinson and Diego Cantarovich
    Citation: Translational Medicine Communications 2023 8:15
    Content type: Research Published on:

  39. Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) s...

    Authors: Jodie L. Morris, Peter C. McEwen, Hayley L. Letson and Geoffrey P. Dobson
    Citation: Translational Medicine Communications 2023 8:14
    Content type: Research Published on:

  40. Management of mechanically ventilated patients can be improved with monitoring of key pulmonary function parameters that facilitate individualization and optimization. The VQm Pulmonary Health Monitor™ (PHM) (...

    Authors: Maximilian Edlinger-Stanger, Caroline Fritz, Hanna C. McGregor, Spencer L. Bustin, Nathan Ayoubi, Harpreet K. Bath, Johannes Müller, Sebastian Kühnl-Brady, Thomas Schweiger, Julia Jedamzik, Marita Windpassinger, Michael Hiesmayr, Bernard P. Cholley and Neal W. Fleming
    Citation: Translational Medicine Communications 2023 8:13
    Content type: Research Published on:

  41. Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutroph...

    Authors: Victoria L. M. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, David B. Seder, Nelson Ruiz-Opazo and Allan J. Walkey
    Citation: Translational Medicine Communications 2023 8:12
    Content type: Research Published on:

  42. Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient’s cells...

    Authors: Shivani Thoidingjam, Sushmitha Sriramulu, Svend Freytag, Stephen L. Brown, Jae Ho Kim, Indrin J. Chetty, Farzan Siddiqui, Benjamin Movsas and Shyam Nyati
    Citation: Translational Medicine Communications 2023 8:11
    Content type: Review Published on:

  43. Rheumatoid Arthritis is one of the most common autoimmune diseases, causing irreversible joint damage and disability. Methotrexate (MTX) is the gold standard drug for this. The low cost, easy availability and ...

    Authors: Harjit Singh Nalwa, Peeyush Prasad, Nirmal Kumar Ganguly, Ved Chaturvedi and Shivani Arora Mittal
    Citation: Translational Medicine Communications 2023 8:10
    Content type: Review Published on:

  44. Preclinical studies have demonstrated the potential use of induced pluripotent stem cells (iPSCs) to treat cardiovascular disease (CVD). In vivo preclinical studies conducted on animal models (murine, porcine,...

    Authors: Ryan Bellman, Jishizhan Chen, Lidan Chen, Nikolitsa Nomikou, Janice Tsui, George Hamilton and Wenhui Song
    Citation: Translational Medicine Communications 2023 8:9
    Content type: Research Published on:

  45. Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found o...

    Authors: John Mukisa, Marion Amujal, Obondo J. Sande, Moses L. Joloba, Daudi Jjingo, David P. Kateete, Graeme Mardon, Mogomotsi Matshaba, Neil Hanchard and Jill A. Hollenbach
    Citation: Translational Medicine Communications 2023 8:8
    Content type: Review Published on:

  46. Electronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not w...

    Authors: Cosby G. Arnold, Brandon Sonn, Frederick J. Meyers, Alexis Vest, Richie Puls, Estelle Zirkler, Michelle Edelmann, Ian M. Brooks and Andrew A. Monte
    Citation: Translational Medicine Communications 2023 8:7
    Content type: Review Published on:

  47. Prophylactic platelet transfusion is given to patients when the platelet count is less than ten thousand to prevent clinically significant bleeding till platelet engraftment is documented. Despite a very low p...

    Authors: Zainab Ghias, Uzma Zaidi, Munira Borhany, Shafaq Abdul Samad, Noureen Durrani, Mushkbar Fatima, Sidra Zafar, Aisha Jamal and Tahir Shamsi
    Citation: Translational Medicine Communications 2023 8:6
    Content type: Research Published on:

  48. This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment.

    Authors: Joaquina C. Baranda, Ghulam Rehman Mohyuddin, Andrés M. Bur, Yelizaveta Shnayder, Kyle R. Sweeney, Kiran Kakarala, Megan Prouty, Harsh Pathak, Rajni Puri, Amrita Mitra, Rashna Madan, M. Laird Forrest, Aric Huang, Scott Weir, Andrew K. Godwin, Nabil A. Alhakamy…
    Citation: Translational Medicine Communications 2023 8:5
    Content type: Research Published on:

  49. Intrathecal (IT) catheter delivery of baclofen via continuous infusion using an implantable pump is an important means of treating patients with severe spasticity. We evaluated the impact of IT catheter tip pl...

    Authors: Brian A. Duclos, Cindy Roegge, Howard Dobson, Scott Haller, Jeff Bodner, Sanjana Pannem, Janelle Gesaman and Amin Nourmohammadi
    Citation: Translational Medicine Communications 2023 8:4
    Content type: Research Published on:

  50. The BRAF and MEK inhibitors combined strategies have dramatically changed the outcome of BRAF-mutated metastatic melanoma patients. However, despite the initial promising results, the onset of primary or acqui...

    Authors: Valentina Belli, Stefania Napolitano, Vincenzo De Falco, Gabriella Suarato, Alessandra Perrone, Luigi Pio Guerrera, Giulia Martini, Carminia Maria Della Corte, Erika Martinelli, Floriana Morgillo, Mimmo Turano, Maria Furia, Giuseppe Argenziano, Davide Ciardiello, Fortunato Ciardiello and Teresa Troiani
    Citation: Translational Medicine Communications 2023 8:3
    Content type: Research Published on:
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Translational Medicine Communications

ISSN: 2396-832X

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