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  1. Content type: Research

    Colorectal cancer (CRC) is the third most common cancer worldwide, and its incidence is expected to increase to over 2.2 million new cases in 2030. Stage II CRC is classified as localized disease, while stage ...

    Authors: Matilda Holm, Sakari Joenväärä, Mayank Saraswat, Tiialotta Tohmola, Ari Ristimäki, Risto Renkonen and Caj Haglund

    Citation: Translational Medicine Communications 2019 4:14

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  2. Content type: Research

    Even as the eukaryotic stranded DNA is known to heterochromatinize at the nuclear envelope in response to mechanical strain, the precise mechanistic basis for alterations in chromatin gene transcription in dif...

    Authors: Hemant Sarin

    Citation: Translational Medicine Communications 2019 4:13

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  3. Content type: Review

    Prevalence of diabetes and comorbid brain disorders is increasing worldwide particularly in low- and middle-income countries. Diabetes and its complications impose substantial economic costs on the developing ...

    Authors: Ajit Kumar Thakur, Sakshi Tyagi and Nikhila Shekhar

    Citation: Translational Medicine Communications 2019 4:12

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  4. Content type: Methodology

    Interleukin-17A (IL-17A) is a potent pro-inflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The production of IL-17A is commonly associated with subsets of CD4+ ...

    Authors: Pradeep K. Dagur, Elena Stansky, Ankit Saxena, Angélique Biancotto and John Philip McCoy Jr

    Citation: Translational Medicine Communications 2019 4:11

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  5. Content type: Research

    Understanding pediatric cancer biology is a huge challenge in continuous development that is currently being implemented into the clinical practice thanks to the new high throughput technologies integrated by ...

    Authors: Pablo Gargallo, Jaime Font de Mora, Pablo Berlanga, Inés Calabria, Margarita Llavador, Laia Pedrola, Joaquín Panadero, Sandra Dolz, Ángel Zúñiga, Juan Silvestre Oltra, Paloma Escobar, Yania Yáñez, María José Aparisi, Marina Martinez-Matilla, Vanessa Segura, Carlos Esquembre…

    Citation: Translational Medicine Communications 2019 4:10

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  6. Content type: Research

    Endometriosis impacts 6–10% of all reproductive- age women. Studies have shown the more effectively endometriosis is removed, the better the patient outcomes for pain reduction and fertility (2, 3). Hemosideri...

    Authors: Andrew G. Cabe, Arnold D. Estrada, Taylor Hoyt, Xiao Yang, Scott Jenney, Philip T. Valente, Bryan Cox, Jessica E. McLaughlin, Randal D. Robinson, Thomas E. Milner and Marc D. Feldman

    Citation: Translational Medicine Communications 2019 4:9

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  7. Content type: Research

    Viral load (VL) monitoring in the clinical follow-up of HIV patients to detect treatment failure is not routinely offered in Cameroon. The study was designed to characterize virological response on antiretrovi...

    Authors: Juste Patient Mbébi Enoné, Calixte Ida Penda, Serge Bruno Ebong, Madeleine Mbangue, Samuel Honoré Mandengué and Carole Else Eboumbou Moukoko

    Citation: Translational Medicine Communications 2019 4:8

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  8. Content type: Research

    Tuberculosis (TB) remains a debilitating, deadly disease that warrants innovative research tools to fully understand the pathogenesis and host immune responses, particularly at the site of infection and diseas...

    Authors: Carly Young, Petri Ahlers, Andriette M. Hiemstra, Andre G. Loxton, Andrea Gutschmidt, Stephanus T. Malherbe, Gerhard Walzl and Nelita Du Plessis

    Citation: Translational Medicine Communications 2019 4:7

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  9. Content type: Research

    Intraductal Papillary Mucinous Neoplasia (IPMN) are potentially malignant cystic tumors of the pancreas. IPMN can progress from low to moderate to high grade dysplasia and further to IPMN associated carcinoma....

    Authors: Mayank Saraswat, Heini Nieminen, Sakari Joenvaara, Tiialotta Tohmola, Hanna Seppänen, Ari Ristimäki, Caj Haglund and Risto Renkonen

    Citation: Translational Medicine Communications 2019 4:6

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  10. Content type: Research

    Apoptosis inhibition depends on the balance between expression of some regulatory genes including Bax and c-FLIP, despite breast cancer has long been associated with disturbances in apoptosis regulation. The obje...

    Authors: Esmaeil Mahmoudi, Mahdieh Abolfathi, Naiemeh Hassanzadeh, Yaser Eshaghi Milasi, Mina Dehghani-Samani, Mansoor Khaledi, Hossein Kerdarian, Mina Najafipour and Asghar Arshi

    Citation: Translational Medicine Communications 2019 4:5

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  11. Content type: Research

    The CD39/CD73/adenosine suppression pathway correlates with disease progression in patients with chronic human immunodeficiency virus 1 (HIV-1) infection; however, the relationships between this pathway in B c...

    Authors: Wen-Xian Chang, Hui-Huang Huang, Lei Huang, Ji-Jing Shi, Yan-Mei Jiao, Chao Zhang, Lei Jin, Tao Yang, Ming Shi, Bo Tu, Zhe Xu, Tian-Jun Jiang, Fu-Sheng Wang and Ji-Yuan Zhang

    Citation: Translational Medicine Communications 2019 4:4

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  12. Content type: Review

    Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the peo...

    Authors: Abhinav Kanwal and Liston Augustine Dsouza

    Citation: Translational Medicine Communications 2019 4:3

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  13. Content type: Review

    Although durable clinical responses are achieved in a significant number of patients given Immune checkpoint inhibitors (ICI), like anti-CTLA-4 and anti-PD-1 inhibitors, some of the cancers have shown little o...

    Authors: Puneet Singh, Paul de Souza, Kieran F. Scott, Bruce M. Hall, Nirupama D. Verma, Therese M. Becker, James W. T. Toh, Mila Sajinovic and Kevin J. Spring

    Citation: Translational Medicine Communications 2019 4:2

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  14. Content type: Review

    Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-rece...

    Authors: Iman W. Achkar, Ajaz A. Bhat, Maria Zafar, Madiha Abbas, Omar S. Khan, Shilpa Kuttikrishnan, Kirti S. Prabhu and Shahab Uddin

    Citation: Translational Medicine Communications 2019 4:1

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  15. Content type: Research

    Autoimmune diseases are syndromes characterized by an immune response against self-antigens. They are complex pathologies associated with a variety of genetic determinants, but these genes cannot fully explain...

    Authors: Leydy Katherin Duque Suárez, Gerardo Quintana López, Paola Ximena Coral Alvarado, Paul Alejandro Méndez Patarroyo, Helena Groot deRestrepo and Valeriano López-Segura

    Citation: Translational Medicine Communications 2018 3:11

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  16. Content type: Research

    Endothelial surface glycocalyx shedding plays a role in endothelial dysfunction and increases vessel wall permeability, which can lead to inflammation and atherogenesis. We sought to elucidate whether a high f...

    Authors: Ronodeep Mitra, Ju Qiao, Sudharsan Madhavan, Gerard L. O’Neil, Bailey Ritchie, Praveen Kulkarni, Srinivas Sridhar, Anne L. van de Ven, Erica M. Cherry Kemmerling, Craig Ferris, James A. Hamilton and Eno E. Ebong

    Citation: Translational Medicine Communications 2018 3:10

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  17. Content type: Research

    Down Syndrome (DS) has a very high morbidity, according to statistics, the incidence rate of DS is as high as 1:700 among the new born babies. At present, there are still no effective prevention or treatment m...

    Authors: Weiguo Sui, Qing Gan, Wei Wei Gong, Xiaolian Wei, Minglin Ou, Donge Tang, Huanyun Jing, Hua Lin, Yue Zhang and Yong Dai

    Citation: Translational Medicine Communications 2018 3:9

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  18. Content type: Research

    The Notch pathway combined with other signalling molecules acts specifically for the development of each blood cell type and differentiation stage. A causative role of Notch dysfunction in leukaemia developmen...

    Authors: Luka Horvat, Josipa Skelin, Biljana Jelić Puškarić, Isidoro Feliciello, Darko Heckel, Josip Madunić, Ika Kardum-Skelin, Maja Matulić, Delfa Radić-Krišto and Mariastefania Antica

    Citation: Translational Medicine Communications 2018 3:8

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  19. Content type: Research

    GNE myopathy (distal myopathy with rimmed vacuoles) is a rare intractable muscle disease caused by the mutations in GNE gene, with no therapeutic agents at present. The mutations in GNE (UDP-N-acetylglucosamine 2...

    Authors: Naoki Suzuki, Masaaki Kato, Hitoshi Warita, Rumiko Izumi, Maki Tateyama, Hiroshi Kuroda, Ryuta Asada, Akifumi Suzuki, Takuhiro Yamaguchi, Ichizo Nishino and Masashi Aoki

    Citation: Translational Medicine Communications 2018 3:7

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  20. Content type: Research

    There is no consensus therapy recommended for recurrent malignant gliomas (MGs). In 2009, Bevacizumab (BEV) was approved by the FDA as single-agent for recurrent glioblastoma (GBM). The aim of this retrospecti...

    Authors: Arsela Prelaj, Sara Elena Rebuzzi, Maurizio Salvati, Silvia Pecorari, Chiara Pozzi, Carmela Fusto, Carla Ferrara, Silverio Tomao and Vincenzo Bianco

    Citation: Translational Medicine Communications 2018 3:6

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  21. Content type: Research

    A role for sex hormone-binding globulin (SHBG) in determining the pregnancy outcome was evidenced by the rise in SHBG levels during pregnancy linked with favorable pregnancy, while reduction in SHBG levels and...

    Authors: Mariam Dendana, Ramzi R. Finan, Mariam Al-Mutawa and Wassim Y. Almawi

    Citation: Translational Medicine Communications 2018 3:5

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  22. Content type: Research

    It is known that rheumatoid symptoms improve in pregnancy and in patients who develop infective jaundice. The mechanism of amelioration might involve the direct interaction of free endosomal self-epitopes that...

    Authors: Innocenzo Caruso, Enzo Massimo Caruso, Salvatore Santandrea, Franco Montrone, Piercarlo Sarzi Puttini and Marco Cazzola

    Citation: Translational Medicine Communications 2018 3:4

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  23. Content type: Review

    The foreign antigen that enters into the body is detected by the immune system through antigen presenting cells leading to the production of antibodies. The use of anti-idiotype antibodies is a new way to exci...

    Authors: Ahsan Naveed, Sajjad Ur Rahman, Muhammad Imran Arshad and Bilal Aslam

    Citation: Translational Medicine Communications 2018 3:1

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  24. Content type: Research

    The Solanum species have been used for the treatment of warts, tumor and cancer in folk medicine. The S. incanum extract is an important traditional Chinese medicine in Taiwan since 1973. The purpose of the prese...

    Authors: Yeong-Chang Chen, Meng-Ru Shen, Ai-Li Shiau, Hamm-Ming Sheu, Yu-Lin Liang and Keng-Fu Hsu

    Citation: Translational Medicine Communications 2017 2:8

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  25. Content type: Research

    This study aimed to develop and assess a practical prognostic lncRNA signature for squamous cell carcinoma of the lung (LUSC).

    Authors: Xiaoshun Shi, Fuxi Huang, Xiaobing Le, Xiaoxiang Li, Kailing Huang, Baoxin Liu, Viola Yingjun Luo, Yanhui Liu, Zhuolin Wu, Allen Menglin Chen, Ying Liang and Jiexia Zhang

    Citation: Translational Medicine Communications 2017 2:7

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  26. Content type: Research

    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential regulator of glycolysis used as a housekeeping marker for gene/protein normalisation. Given the pivotal role of GAPDH in tumour metabolism, our ...

    Authors: Míriam Tarrado-Castellarnau, Santiago Diaz-Moralli, Ibrahim H. Polat, Rebeca Sanz-Pamplona, Cristina Alenda, Víctor Moreno, Antoni Castells and Marta Cascante

    Citation: Translational Medicine Communications 2017 2:6

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  27. Content type: Methodology

    The challenge for prostate cancer (PCa) diagnosis is to improve the ability to distinguish indolent from aggressive PCa. Increased urinary levels of Distal-less Homeobox 1 (DLX1) and Homeobox C6 (HOXC6) mRNA have...

    Authors: Daphne Hessels, Hans de Jong, Sander A. Jannink, Michael Carter, Manuel Krispin, Wim Van Criekinge, Leander Van Neste and Jack A. Schalken

    Citation: Translational Medicine Communications 2017 2:5

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  28. Content type: Research

    In Cameroon, as in many malaria endemic countries in Africa, blood donors are not routinely screened for Plasmodium infection that potentially could lead to severe malaria in some recipients. This study aimed at ...

    Authors: Cécile Okalla Ebongue, Eveline Ngouadjeu Dongho, Gaétan Texier, Jean-Pierre Nda Mefo’o, Gerald Sume Etapelong, Lawrence Ayong and Carole Else Eboumbou Moukoko

    Citation: Translational Medicine Communications 2017 2:4

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  29. Content type: Research

    Lymphopenia commonly occurs in cancer patients and predicts poor prognosis. It is caused by radio- and chemotherapy, with malnutrition and treatment-related oxidative stress playing key roles in its pathogenes...

    Authors: Dolores Margarita Rodríguez, Mery Elizabeth Guerrero, Bárbara Marisol Maldonado, Claudia Vollbracht and Sandra Aracely Herrera

    Citation: Translational Medicine Communications 2017 2:3

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  30. Content type: Research

    The employment status of workers with chronic hepatitis C has important implications for society and labor market, for organizations and for the individuals and their economic, social and psychological status....

    Authors: Giulia Malaguarnera, Gaetano Bertino, Carmela Greco, Caterina Gagliano, Massimo Motta, Giuseppe Chisari, Venerando Rapisarda, Giuseppe Nunnari, Michele Vecchio, Filippo Drago and Michele Malaguarnera

    Citation: Translational Medicine Communications 2017 2:2

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  31. Content type: Research

    Coronary artery diseases (CAD) are the most commonly occurring disorders in the developed countries. Development of new therapeutics and their success in clinical studies require confirmation of therapeutic ef...

    Authors: Akinori Hirano, Jun Fujita, Hideaki Kanazawa, Shinji Kawaguchi, Noriko Handa, Yoshitake Yamada, Shigeo Okuda, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Shugo Tohyama, Tomohisa Seki, Ryota Tabei, Kazuaki Nakajima, Yoshikazu Kishino, Marina Okada…

    Citation: Translational Medicine Communications 2017 2:1

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  32. Content type: Research

    The Vhembe region of the Limpopo province has a rich tradition of medicinal plants use. Traditionally, boiled roots of Ziziphus mucronata are used in the treatment of boils, general swelling and other skin infect...

    Authors: M. T. Sigidi, C. P. Anokwuru, T. Zininga, M. P. Tshisikhawe, A. Shonhai, I. D. I. Ramaite, A. N. Traoré and N. Potgieter

    Citation: Translational Medicine Communications 2016 1:9

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  33. Content type: Research

    Thymosin beta 4 is a promising agent in preclinical regenerative and cardioprotection research. After myocardial injury it improves cell survival, reduces inflammation and activates epicardial progenitor cells...

    Authors: Christoffer Stark, Mikko Helenius, Pekka Taimen, Rasmus Kentala, Antti Saraste, Tero-Pekka Alastalo, Timo Savunen and Juha Koskenvuo

    Citation: Translational Medicine Communications 2016 1:8

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  34. Content type: Research

    IgA nephropathy (IgAN) exhibits a variable course ranging from a benign condition to progressive renal failure with a high proportion of patients undergoing end-stage renal disease in the long term. It is uncl...

    Authors: Patrizia Viola, Lucia Centurione, Paolo Felaco, Giuseppe Lattanzio, Tommaso D’Antuono, Marcella Liberatore, Roberta Di Pietro, Franco Oreste Ranelletti, Mario Bonomini and Francesca Bianca Aiello

    Citation: Translational Medicine Communications 2016 1:7

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  35. Content type: Protocol

    Obesity is characterized by impaired fat oxidation, and, therefore, the development of therapeutics designed to enhance fat oxidation for treating obesity is a growing focus in drug discovery. Evaluating such ...

    Authors: Stephanie A. Parsons, Karen P. Jones, Fanchao Yi, Christopher P. Bock, Christopher J. Petucci, Stella K. Betancourt, Stephen J. Gardell and Steven R. Smith

    Citation: Translational Medicine Communications 2016 1:6

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  36. Content type: Research

    Cystic fibrosis (CF) is the most common life-threatening inherited disease in the Caucasian population. It is caused by genetic defects in the cystic fibrosis transmembrane conductance regulator gene (CFTR), a cA...

    Authors: Elena Fernández Fernández, Nadine Bangel-Ruland, Katja Tomczak and Wolf-Michael Weber

    Citation: Translational Medicine Communications 2016 1:5

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  37. Content type: Research

    Breast Cancer in the Middle East and North Africa region (MENA) occurs in a younger age group of patients and is more aggressive than in Europe and North America. Little is known about the presence of immune i...

    Authors: Mahmoud Mohamed, Hina Sarwath, Nada Salih, Devendra Bansal, Prem Chandra, Nazik E. Husain, Lotfi Chouchane, Ali A. Sultan and Shahinaz Bedri

    Citation: Translational Medicine Communications 2016 1:4

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  38. Content type: Research

    Migration and invasion are hallmarks of cancer cells that allow their dissemination to other tissues. Studying the cellular and molecular basis of cancer cell migration can help us to understand and control ca...

    Authors: Fabiana Sélos Guerra, Luzia da Silva Sampaio, Sandra Konig, Martin Bonamino, Maria Isabel Doria Rossi, Manoel Luis Costa, Patricia Fernandes and Claudia Mermelstein

    Citation: Translational Medicine Communications 2016 1:3

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  39. Content type: Research

    Low-grade inflammation plays significant role in the development of diabetes mellitus type 2 (DM2) and impaired glucose tolerance (IGT), but immune regulatory mechanisms involved in these processes are studied...

    Authors: Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Koshelskaya, Irina V. Vinnizkaya and Sergey V. Popov

    Citation: Translational Medicine Communications 2016 1:2

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