Articles

A novel method for maintaining the stability of freshly cultured Mesenchymal stem cells in clinical grade injection ready state without cryopreservation

Mesenchymal Stem Cells (MSCs) are multipotent cells with low immuonogenecity, and dynamic tissue repair potential, which explains the overwhelming attention they have attracted in regenerative therapy. One not...

Authors: Mandana Mohyeddin Bonab, Fatemeh Talebian, Aida Borzabadi, Vahideh Nasr, Azam Abedi Kooshlshahi, Fahime Anisie, Ronaz Haghshenas, Bita Shalbafan, Ehsan Janzamin and Saeed Shahbeigi

PhiΦBreast & theory of spiral cancer new diagnostic techniques for breast cancer detection

Today, breast cancer is one of the most aggressive cancers in women and new cases continue to increase worldwide. The incidence of this tumor is kept under control especially with surgery. In order to reduce m...

Authors: Ersilio Trapanese and Giulio Tarro

The protective role of statins in COVID-19 patients: a retrospective observational study

To evaluate and determine the protective role of statins in COVID-19 patients.

Authors: Srikanth Umakanthan, Sanjum Senthil, Stanley John, Mahesh K. Madhavan, Jessica Das, Sonal Patil, Ragunath Rameshwaram, Ananya Cintham, Venkatesh Subramaniam, Madhusudan Yogi, Abhishek Bansal, Sumesh Achutham, Chandini Shekar, Vijay Murthy and Robbin Selvaraj

Application of a composite measure of product adherence, protocol compliance, and semen exposure to a phase III microbicide HIV prevention trial

Strict adherence to antiretroviral-based microbicide use is important for effective HIV prevention. We previously developed a composite measure of product adherence, protocol compliance, and semen exposure for...

Authors: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Tina Cunningham, Susan Ju, Jill L. Schwartz, Sinead Delany-Moretlwe, Andrea R. Thurman and Gustavo F. Doncel

Clinical progression of patients with COVID-19 in Lagos State, Nigeria

The majority of COVID-19 research has been devoted to characterizing the epidemiology and early clinical aspects of the virus. In Lagos, Nigeria, we looked at the temporal progression of COVID-19 patients. We ...

Authors: JP. C. Mbagwu, J. O. Olajugba, Paula-Peace James-Okoro and Obidike Blessing

Correction to: Mesenchymal stem cells in the treatment of severe COVID-19

Authors: Santosh Kesari, Gregory C. Kasper, Lev Verkh, Terese C. Hammond, Marla L. Matal, Jay W. Hammerling, Nikolai Tankovich, Adrianus P. Lim, Kevin H. Zhao, Tiffany Juarez, Roberta E. Redfern, Jaya M. Gill, Natsuko Nomura, Audrey Hiemer, Annie Heng and Jessica Shoemaker

Idiotype/anti-idiotype antibodies: as a glorious savior in COVID-19 pandemics

The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune response...

Authors: Ahsan Naveed, Deeba Naz and Sajjad ur Rahman

Predictive model and feature importance for early detection of type II diabetes mellitus

Accurate prediction and early recognition of type II diabetes (T2DM) will lead to timely and meaningful interventions, while preventing T2DM associated complications. In this context, machine learning (ML) is ...

Authors: Eric Adua, Emmanuel Awuni Kolog, Ebenezer Afrifa-Yamoah, Bright Amankwah, Christian Obirikorang, Enoch Odame Anto, Emmanuel Acheampong, Wei Wang and Antonia Yarney Tetteh

Mesenchymal stem cells in the treatment of severe COVID-19

Authors: Santosh Kesari, Gregory C. Kasper, Lev Verkh, Terese C. Hammond, Marla L. Matal, Jay W. Hammerling, Nikolai Tankovich, Adrianus P. Lim, Kevin H. Zhao, Tiffany Juarez, Roberta E. Redfern, Jaya M. Gill, Natsuko Nomura, Audrey Hiemer, Annie Heng and Jessica Shoemaker

Behavioural symptoms of mental health disorder such as depression among young people using Instagram: a systematic review

There is a growing debate on the linkage between social networking platforms and mental health disorder, such as depressive behaviour or depression. However, the relationship between Instagram use and depressi...

Authors: Gbadebo Collins Adeyanju, Ron Patrick Solfa, Thuy Linh Tran, Sophia Wohlfarth, Jonas Büttner, Oluyomi A. Osobajo and Afolabi Otitoju

StemForte Plus® for stem cell activation and telomerase activity for anti-aging purposes

Authors: Victor Chavez

Preexisting vs. de novo antibodies against SARS-CoV-2 in individuals without or with virus infection: impact on antibody therapy, vaccine research and serological testing

The causative agent of the ongoing pandemic in the world is SARS-CoV-2. The research on SARS-CoV-2 has progressed with lightning speed on various fronts, including clinical research and treatment, virology, ep...

Authors: Kar Muthumani, Ziyang Xu, Moonsup Jeong, Joel N. Maslow, Vaniambadi S. Kalyanaraman and Alagarsamy Srinivasan

Does Covera-19 know ‘when to hold ‘em or ‘when to fold ‘em? A translational thought experiment

The function of proteins depends on their structure. The structural integrity of proteins is dynamic and depends on interacting nearby neighboring moieties that influence their properties and induce folding an...

Authors: Gerald Dieter Griffin

Impact of parasitic infection on human gut ecology and immune regulations

The human body harbors trillions of microbes collectively known as microbiota. The human gut microbiota is importantly involved in most of the human metabolic and regulatory pathways. The gut microbiota needs ...

Authors: Ahsan Naveed and Sabahat Abdullah

Effect of hydrolysable tannin on nutrient intake obesity and other associated metabolic risk factors in polycystic rats

Food intake and eating behavior are two important risk factors that lead to obesity and other associated metabolic and reproductive disorders like polycystic ovarian syndrome (PCOS). Most of the phytonutrients...

Authors: Faiza Manzoor, Mahr Un Nisa, Hafiz Amjad Hussain, Muhammad Kamran Khan, Rabia Shabir Ahmad, Nazir Ahmad, Muhammad Imran and Huma Umbreen

Contrast‐enhanced ultrasound imaging can be used to evaluate fetal cerebral perfusion: potential implications for fetal surgery

Fetal surgery is increasingly performed to correct congenital defects. Currently, fetal brain perfusion cannot be assessed intra-operatively. The purpose of this study was to determine if contrast-enhanced ult...

Authors: Kendall M. Lawrence, Barbara E. Coons, Anush Sridharan, Avery C. Rossidis, Marcus G. Davey, Alan W. Flake and Ryne A. Didier

Scavengers of hemoproteins as potential biomarkers for severe sepsis and septic shock

Despite improvements in diagnosis, interventions and supportive care, mortality among sepsis patients is still high. Research of the past decade has attempted to identify biomarkers that can accurately discrim...

Authors: Myrddin W. Verheij, Ingrid Bulder, Walter A. Wuillemin, Carlijn Voermans and Sacha S. Zeerleder

A survey on the current status and future perspective of informed consent management in the MIRACUM consortium of the German Medical Informatics Initiative

The consent management is an essential component for supporting the implementation of consents and withdrawals and thus, the realisation of patient’s rights. In MIRACUM, one of the four consortia of the Medica...

Authors: Christopher Hampf, Martin Bialke, Lars Geidel, Albert Vass, Thomas Bahls, Romina Blasini, Arne Blumentritt, Martin Boeker, Christian Bruns, Burkhard Jandrig, Maximilian Fünfgeld, Philipp Heinrich, Torsten Leddig, Achim Michel-Backofen, Anna Pirkl, Michael Rautenberg…

Is the awakening produced by benzodiazepines due to excitatory actions of GABA?

Benzodiazepines (BZDs) such as Zolpidem can produce a temporary revival of patients who have been akinetic and apathic for years. The mechanisms underlying this “awakening” reaction are suggested globally to b...

Authors: Yehezkel Ben-Ari

Emerging roles of C1Q tumor necrosis factor-related proteins in metabolic diseases

Obesity and insulin resistance are key elements of the metabolic syndrome, which includes type 2 diabetes (T2D), dyslipidemia, systemic inflammation, hypertension, elevated risk for cardiovascular diseases, no...

Authors: Manjunath Ramanjaneya, Jayakumar Jerobin, Ilham Bettahi, Kodappully Sivaraman Siveen and Abdul-Badi Abou-Samra

Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model

There is currently no drug therapy to prevent arthrofibrosis following knee surgery. We aimed to determine if the anti-ischemic and anti-inflammatory drug adenosine, lidocaine and Mg²⁺ (ALM), reduces surgery-rela...

Authors: Jodie L. Morris, Hayley L. Letson, Peter McEwen, Erik Biros, Constantin Dlaska, Kaushik Hazratwala, Matthew Wilkinson and Geoffrey P. Dobson

Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has profoundly affected the lives of millions of people. To date, there is no a...

Authors: Payam Peymani, Tania Dehesh, Farnaz Aligolighasemabadi, Mohammadamin Sadeghdoust, Katarzyna Kotfis, Mazaher Ahmadi, Parvaneh Mehrbod, Pooya Iranpour, Sanaz Dastghaib, Ahmad Nasimian, Amir Ravandi, Biniam Kidane, Naseer Ahmed, Pawan Sharma, Shahla Shojaei, Kamran Bagheri Lankarani…

In vivo optical endomicroscopy: two decades of translational research towards next generation diagnosis of eosinophilic esophagitis

Histopathologic analysis of biopsy specimens obtained via white light endoscopy (WLE) is the gold standard for the diagnosis of several mucosal diseases in the upper gastrointestinal (GI) tract. However, this ...

Authors: Andreas Wartak, John G. Garber, Qian Yuan, Wayne G. Shreffler, Paul E. Hesterberg, Aubrey J. Katz, Hany Osman, Hui Min Leung, Anna Gao, David O. Otuya, Catriona Grant, Joseph A. Gardecki, Norman Nishioka, Guillermo J. Tearney and Gabriela Apiou-Sbirlea

The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic review

Serotonin or 5-hydroxytryptamine (5-HT)- a neurotransmitter of both the Enteric Nervous System and the Central Nervous System is synthesized by the hydroxylation of L- tryptophan to 5-hydroxytryptophan.

Authors: Khushi Bruta, Vanshika, Kishnoor Bhasin and Bhawana

Lung mechanics in type L CoVID-19 pneumonia: a pseudo-normal ARDS

This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long as to explore its variations during prone positioning.

Authors: Lorenzo Viola, Emanuele Russo, Marco Benni, Emiliano Gamberini, Alessandro Circelli, Luca Bissoni, Domenico Pietro Santonastaso, Giovanni Scognamiglio, Giuliano Bolondi, Luca Mezzatesta and Vanni Agnoletti

Plasma lipidome abnormalities in people with HIV initiating antiretroviral therapy

Dyslipidemia often accompanies human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART). Lipid abnormalities likely contribute to increased cardiometabolic disease among people with HIV (P...

Authors: Emily R. Bowman, Manjusha Kulkarni, Janelle Gabriel, Xiaokui Mo, Brett Klamer, Martha Belury, Jordan E. Lake, David Zidar, Scott F. Sieg, Nehal N. Mehta, Martin P. Playford, Daniel R. Kuritzkes, Adriana Andrade, Elizabeth Koss Schmidt, Christopher Taylor, Edgar T. Overton…

Developing a diagnostic method for latent tuberculosis infection using circulating miRNA

Mycobacterium tuberculosis is known to cause latent tuberculosis infection (LTBI) in 25–50% of the cases, of whom 10–20% develop active tuberculosis (TB). Notably, no marker currently exists for judging the thera...

Authors: Shoji Hashimoto, Hong Zhao, Michiyo Hayakawa, Koichi Nakajima, Y-h Taguchi and Yoshiki Murakami

Unexpected increase of myocardial extracellular volume fraction in low cardiovascular risk HIV patients

People living with HIV (PLWH) are prone to develop sub-clinical Cardiovascular (CV) disease, despite the effectiveness of combined Antiretroviral Therapy (cART). Algorithms developed to predict CV risk in the ...

Authors: Cristian Borrazzo, Gabriella d’Ettorre, Giancarlo Ceccarelli, Massimiliano Pacilio, Letizia Santinelli, Eugenio Nelson Cavallari, Ornella Spagnolello, Valeria Silvestri, Paolo Vassalini, Carolina Scagnolari, Marco Francone, Claudio Maria Mastroianni and Iacopo Carbone

Building a rapid autopsy program – a step-by-step logistics guide

Rapid Autopsy Programs offer an opportunity to collect tissue from patients immediately after death, providing critical biological material necessary to develop more effective therapies and improve patient out...

Authors: Eliza R. Bacon, Kena Ihle, Peter P. Lee and James R. Waisman

Cell Banking of HEK293T cell line for clinical-grade lentiviral particles manufacturing

Cell banks are widely used to preserve cell properties as well as to record and control the use of cell lines in biomedical research. The generation of cell banks for the manufacturing of Advanced Therapy Medi...

Authors: Unai Perpiñá, Cristina Herranz, Raquel Martín-Ibáñez, Anna Boronat, Felipe Chiappe, Verónica Monforte, Gemma Orpella-Aceret, Ester González, Myriam Olivé, María Castella, Guillermo Suñé, Álvaro Urbano-Ispizua, Julio Delgado, Manel Juan and Josep M. Canals

Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease

Since the birth of Christ, in these 2019 years, the man on earth has never experienced a survival challenge from any acellular protist compared to SARS-CoV-2. No specific drugs yet been approved. The host immu...

Authors: Kishalay Paria, Debarati Paul, Trinath Chowdhury, Smritikana Pyne, Ranadhir Chakraborty and Santi M. Mandal

Performance evaluation of the novel portable PIMA point-of-care CD4 analyzer in comparison with conventional flow cytometer instruments in Cameroon

Absolute CD4+ T-lymphocyte counts are used in the initiation and monitoring of antiretroviral therapy in HIV-infected patients: with the increase number of HIV infected patient and the reduce number of heath c...

Authors: Bertrand Sagnia, Rachel Kamgaing, Charles Kouanfack, Georgette Kamdem, Samuel Sosso, Edith Temgoua, Zéphyrin Tsomo, Lucille Mabouli Zoa, Charlotte Tangimpundu, Godwin Nchinda and Alexis Ndjolo

Prevent Cancer Foundation quantitative CT imaging workshop XVI: lung cancer, COPD and cardiovascular disease - on the cusp of transformation, Arlington, VA

Throughout the course of this Workshop, members of the advocacy community, imaging researchers, computer and measurement scientists, clinicians and policy-focused workshop attendees engaged in cross-cutting di...

Authors: James L. Mulshine, Riccardo S. Avila, Daniel C. Sullivan, David F. Yankelevitz, Raúl San José Estépar, Laurie Fenton Ambrose, Bruce Pyenson and Carolyn R. Aldigé

Identification of repurposable cytoprotective drugs in vanishing white matter disease patient-derived cells

Vanishing white matter disease (VWMD) is a rare disease caused by mutations of the guanine exchange factor eIF2B. VWMD typically presents with juvenile onset, and there are few treatments for the disease. Rece...

Authors: Neville Ng, Mauricio Castro Cabral-da-Silva, Simon Maksour, Tracey Berg, Martin Engel, Dina M. Silva, Dzung Do-Ha, Jeremy S. Lum, Sonia Sanz Muñoz, Nadia Suarez-Bosche, Claire H. Stevens and Lezanne Ooi

Hospitalized COVID-19 patients treated with convalescent plasma in a mid-size city in the Midwest

SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a s...

Authors: William R. Hartman, Aaron S. Hess and Joseph P. Connor

Lost in translation: barriers and progress in harnessing basic medical science into community practice in Indonesia

Translational research carries over fundamental laboratory research findings into clinical and community settings in order to ‘translate’ the findings into practice. In addition to its potential in acceleratin...

Authors: Ajib Diptyanusa and Mubasysyir Hasanbasri

Identifying pathophysiological bases of disease in COVID-19

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that can affect lung physiology encompassing a wide spectrum of severities, ranging from asymptomatic and mild symptoms to severe and fatal case...

Authors: Carla J. Goldin, Ramiro Vázquez, Fernando P. Polack and Damian Alvarez-Paggi

C-C chemokine receptor type 5 links COVID-19, rheumatoid arthritis, and Hydroxychloroquine: in silico analysis

Patients with rheumatoid arthritis (RA) represent one of the fragile patient groups that might be susceptible to the critical form of the coronavirus disease − 19 (COVID-19). On the other side, RA patients hav...

Authors: Mahmood Y. Hachim, Ibrahim Y. Hachim, Kashif Bin Naeem, Haifa Hannawi, Issa Al Salmi and Suad Hannawi

Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches

Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cron...

Authors: Eman A. Awadelkareem and Sumaia A. Ali

COVID-19 related deaths in an urban academic medical center in Brooklyn – a descriptive case series

Available studies are lacking in analysis of baseline demographics and hospital presentation of patients at risk of expiring due to coronavirus disease 2019 (COVID-19), particularly Black American patients. We...

Authors: James Andrew McCracken, Mohamed Nakeshbandi, Jeffrey Arace, Wayne J. Riley and Roopali Sharma

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial

Surgical cryothermia and radiofrequency (RF) ablations for atrial fibrillation (AF) seem to result in similar sinus rhythm restoration, but the biochemical consequences of the two methods are unclear. We aimed...

Authors: Gabriella Boano, Meriam Åström Aneq, Giannis Spyrou, Helena Enocsson, Emmanouil Charitakis and Farkas Vánky

Individualized body bioelectrical impedance parameters in newly diagnosed cancer children

The bioelectric impedance analysis permits to estimate electrical parameters and body composition of subjects who are either apparently healthy or sick with different pathologies. The aim of this study is to i...

Authors: Taira Teresa Batista Luna, Maraelys Morales González, Manuel Verdecia Jarque, Tamara Rubio González, Soraida Candida Acosta Brooks, Antonio Rafael Selva Castañeda, Justa Carmen Columbié Regüeiferos, Victoriano Gustavo Sierra González and Luis Enrique Bergues Cabrales

Rationale and design of the HIT-CF organoid study: stratifying cystic fibrosis patients based on intestinal organoid response to different CFTR-modulators

Cystic fibrosis is a rare recessive monogenic disease caused by loss-of-function mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Recently developed CFTR-modulators (i.e. drugs th...

Authors: Peter van Mourik, Sabine Michel, Annelotte M. Vonk, Jeffrey M. Beekman and Cornelis K. van der Ent

Transcriptional and free radical responses to LVAD therapy

Myocardial recovery with Left ventricular assistant device (LVAD) therapy is dichotomous with some patients obtaining remission from end-stage heart failure whereas most require transplantation or remain on pu...

Authors: Kajari Dhar, Asmini KC, Fang Qiu, Hesham Basma, Krupa K. Savalia, Jocelyn Jones, Alexandra M. Moulton, Matthew C. Zimmerman, John Um, Daniel Anderson, Marshall Hyden and Brian D. Lowes

Translating pharmacogenetics from research to routine clinical practice – a survey of the IGNITE Network

Translating pharmacogenetic research findings that have shown clinical efficacy into sustainable, routine clinical care at the institutional level requires strong evidence of improved patient outcomes bolstere...

Authors: Kenneth D. Levy, R. Ryanne Wu, Daisuke Goto, Michelle A. Ramos, Victoria M. Pratt, J. Kevin Hicks, Ebony B. Madden, Gillian C. Bell, Kathryn V. Blake, Michelle Cohen, Benjamin Q. Duong, James P. Franciosi, Lori A. Orlando, Kunal Sanghavi and Geoffrey S. Ginsburg

Machine learning-selected variables associated with CD4 T cell recovery under antiretroviral therapy in very advanced HIV infection

A considerable portion of the HIV pandemic is composed of people under antiretroviral therapy, many of whom get a late diagnosis. Patients starting antiretroviral therapy (ART) at a very advanced stage of HIV ...

Authors: Dámaris P. Romero-Rodríguez, Carlos Ramírez, Iván Imaz-Rosshandler, Christopher E. Ormsby, Amy Peralta-Prado, Gustavo Olvera-García, Fernanda Cervantes, Daniela Würsch-Molina, Jessica Romero-Rodríguez, Wei Jiang, Gustavo Reyes-Terán and Enrique Espinosa

Comparative molecular cell-of-origin classification of diffuse large B-cell lymphoma based on liquid and tissue biopsies

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtyp...

Authors: Ewan Hunter, Ronald McCord, Aroul S. Ramadass, Jayne Green, Jurjen W. Westra, Kirsten Mundt and Alexandre Akoulitchev

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with...

Authors: Jorming Goh, Peter Hofmann, Ning Hong Aw, Poh Ling Tan, Gerhard Tschakert, Alexander Mueller, Siew Cheng Wong, Frankie Tan and Linda Seo Hwee Gan

Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis

Osteoarthritis is the most common joint damage that leads to cartilage destruction, pain, and disability. The aim of this study is to investigate the effects of resistance exercises and Nano curcumin supplemen...

Authors: Sadegh Cheragh-Birjandi, Meysam Moghbeli, Farideh Haghighi, Mohammad Reza Safdari, Maryam Baghernezhad, Arash Akhavan and Reza Ganji

Sputum and plasma adiponectin levels in clinically stable adult cystic fibrosis patients with CFTR I1234V mutation

Cystic fibrosis (CF) lung disease is associated with chronic inflammation leading to progress in lung function. Adiponectin is a predominantly anti-inflammatory adipokine that may have a role in CF lung. This ...

Authors: Atqah AbdulWahab, Mona Allangawi, Merlin Thomas, Ilham Bettahi, Siveen K. Sivaraman, Jayakumar Jerobin, Prem Chandra, Abdul-Badi Abou-Samra and Manjunath Ramanjaneya